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Surgery: Breast > Carcinoma In Situ > Flashcards

Carcinoma In Situ Flashcards

1
Q

What are carcinomas in situ?

A

Malignancies that are contained within the basement membrane tissue - seen as premalignant condition

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2
Q

Are they typically symptomatic at presentation?

A

No

Typically found on imaging

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3
Q

What are the 2 main types in breast tissue ?

A

Ductal carcinoma in situ DCIS

Lobular carcinoma in situ LCIS

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4
Q

What is the most common type of non-invasive breast malignancy ?

A

Ductal carcinoma in situ

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5
Q

DCIS comprises what percentage of all breast cancers diagnosed?

A

20%

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6
Q

What percentage of those with DCIS will develop invasive disease ?

A

20-30%

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7
Q

How is DCIS often detected?

A

During screening

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8
Q

How does DCIS appear on a mammogram?

A

Microcalcifications - clusters or linear and branching

Often shows central necrosis

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9
Q

How is DCIS confirmed?

A

On biopsy

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10
Q

How is DCIS managed?

A

Localised: complete wide excision - ensuring surrounding tissue have no residual disease

Widespread/ multi focal : normally complete mastectomy

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11
Q

What is lobular carcinoma in situ a malignancy of?

A

The secretory lobules of the breast that is contained within the basement membrane

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12
Q

Is LCIS or DCIS at more risk of developing an invasive breast malignancy?

A

LCIS

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13
Q

Is LCIS usually diagnosed before or post-menopause?

A

Before

Less than 10% post menopause

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14
Q

Is LCIS associated with microcalcifications?

A

No

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15
Q

Is LCIS usually asymptomatic?

A

Yes

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16
Q

How is LCIS usually diagnosed?

A

Incidental finding during breast biopsy

17
Q

How is LCIS managed?

A

Dependent on extent of disease
Low grade - monitoring rather than excision
If invasive component - bilateral prophylactic mastectomy if individual possess BRCA 1 or 2 , less likely to be associated with axilla ray nodal metastasis than DCIS

18
Q

What grades are there?

A

Low
Intermediate
High

Showing increasing cytological atypia

Surgery: Breast (12 decks)

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