Carcinogensis - Week 13 PBL Flashcards
1
Q
What are the three changes for when a cell becomes tumourigenic?
A
Immortalisation
Fails to follow normal growth constraints
Invasion
2
Q
Name two key tumour suppressor genes?
A
TP53 and MARD2
3
Q
The difference between driver and passenger mutations?
A
Driver - alteration in the cell genome for growth advantage
Passenger - no effect on cell. Mutation in same cell as driver gene
