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Step 1 path > Carcinogens/Oncogenic microbes > Flashcards

Carcinogens/Oncogenic microbes Flashcards

1
Q

Front will have the Carcinogen/microbe and back will have the impact/assoc. cancer

A

FA pg 231

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2
Q

EBV

A

Burkitt Lymphoma, Hodgkin Lymphoma, Nasopharyngeal carcinoma, primary CNS lymphoma (in IC pts)

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3
Q

HBV, HCV

A

Hepatocellular carcinoma (HCC), lymphoma

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4
Q

HHV-8

A

Kaposi Sarcoma

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5
Q

HPV

A

Cervical, penile/anal carcinoma (types 16, 18), head/neck ca., SCC of vulva, vagina
(SCC and adenocarcinoma of cervix)

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6
Q

H pylori

A

Gastric adenocarcinoma and MALT lymphoma

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7
Q

HTLV-1

A

Adult T-cell leukemia/lymphoma

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8
Q

Liver fluke

Clonorchis sinensis

A

Cholangiocarcinoma

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9
Q

Schistosoma haematobium

A

bladder ca. (squamous cell)

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10
Q

Aflatoxins (derived from Aspergillus, which can contaminate stored rice/grains)

A

Hepatocellular carcinoma

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11
Q

Alkylating agents

A

Leukemia/Lymphoma

side effect of chemo

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12
Q

Aromatic amines (ie Benzidine, 2-naphthylamine)

A

Transitional cell carcinoma

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13
Q

Arsenic

A

Angiosarcoma of liver,
Lung ca.,
Squamous cell carcinoma (SCC) of skin
(arsenic is present in cig smoke)

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14
Q

Asbestos

A

Bronchogenic carcinoma of lung, mesothelioma

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15
Q

Carbon tetrachloride

A

Liver: centrilobar necrosis, fatty change

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16
Q

Cig smoke

MC carcinogen worldwide, polycyclic hydrocarbons particularly carcinogenic

A 
Bladder: Transitional cell carcinoma,
Cervical carcinoma,
Esophagus: SCC, adenocarcinoma,
Kidney: Renal cell carcinoma,
Larynx: SCC
Lung: Squamous cell and small cell carcinoma,
Pancreatic adenocarcinoma
17
Q

Ethanol

A

Esophagus: SCC
Liver: Hepatocellular carcinoma

18
Q

Ionizing Radiation

A

Papillary Thyroid carcinoma, AML, CML

due to generation of hydroxyl free radicals

19
Q

Nitrosamines (smoked foods)

A

Gastric ca.

responsible for high rate of stomach carcinoma in Japan

20
Q

Vinyl Chloride

A

Liver: Angiosarcoma

occupational exposure; used to make PVC for use in pipes

21
Q

Naphthylamine

A

Urothelial carcinoma of bladder

dervied from cig smoke

22
Q

Nickel, chromium, berryllium, or silica

A

Lung carcinoma

occupational exposures

23
Q

Nonionizing radiation

A

BCC, SCC, and melanoma of skin

UVB sunlight is MC source

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