Carcinogenesis Flashcards
1
Q
What implied invasiveness in cancer?
A
The ability to break loose from primary tumor, enter the bloodstream/lymphatic vessels and form secundary tumors at other sides in the body
2
Q
What are some overactivating/growth promoting events in cancer?
A
-GF signaling
- Transcription
- Proliferation factors
3
Q
What are some underactivating/growth inhibitory events in cancer?
A
- DNA repair
- Cell cycle arrest
- Apoptosis
4
Q
Name some oncogenes
A
- Growth factors (EGF)
- Growth factors receptors (EGFR)
-Signal transducers (Ras, beta-catenin) - Transcription factors (Myc)
- Programmed cell death regulators (Bcl1)
- ECM regulation (Integrins, MMPs)
5
Q
Name some tumor suppressors
A
-Proteins that regulate transcription factors (Rb, VHL, APC, BRCA1)
- Proteins that repair DNA (BRAC2)
- Apoptosis genes (P53, P21)
- Signal transducer (LKB1)
6
Q
Why are cancer cells using the Anaerobe pathway to produce energy?
A
With Anaerobe pathway, a lot of lactase is produced. The cells need lactase to get building blocks
