Carboprost

Question 1

What is the brand/trade name for carbaprost?

Answer 1

• Hemabate

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Question 2

What is the pharmacologic category/class of carboprost?

Answer 2

• Uterotonic
• Synthetic prostaglandin

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Question 3

What is the mechanism of action of carboprost?

Answer 3

• binds to prostaglandin receptors in uterine muscle, increasing intracellular caclium and stimulating contractions

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Question 4

What is the dose of carboprost for treatment of uterine atony & hemorrhage?

Answer 4

• 250 mcg IM ; repeat at 15-90 minute intervals if needed (max 2 mg)

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Question 5

What is the onset of action for carboprost?

Answer 5

• ??, but sources say it peaks at 15-30 minutes

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
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Question 6

What is an important precautions/contraindication for carboprost?

Answer 6

• Asthma

because it is a prostaglandin, it may precipitate bronchoconstriction

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Carboprost: Drug Information}