Carbonyl Alpha-Substitution Reactions

Question 1

Summary of Reactions (MM Ch 22.a)

Answer 1

Question 2

Summary of Reactions (MM Ch 22.b)

Answer 2

Question 3

Summary of Reactions (MM Ch 22.c)

Question 4

When do you use malonic ester synthesis vs. acetoacetic acid synthesis?

Answer 4

Use malonic ester synthesis when you want an alpha substituted carboxylic acid product or derivative.

Use an acetoacetic acid synthesis if the product you want is an alpha substituted methyl ketone.