carbon

Question 1

strain that results from eclipsed bonds?

Answer 1

torsional strain

Question 2

strain that results from atoms being too close together

Answer 2

van der Waals strain (steric strain

Question 3

strain that results from distortion of bond angles from typical values
(dictated by orbital hybridisation)

Answer 3

angle strain

Question 4

two examples of lipophilic interactions between aromatic rings in drug molecules and biological macromolecules.

Answer 4

Π-stacking and intercalation

Question 5

Positive substituent hydrophobicity constant values imply what?

Answer 5

substituents are more hydrophobic than H

Question 6

negative substituent hydrophobicity constant values imply what?

Answer 6

substituents are less hydrophobic than H

Question 7

what do EWG substituents do to carboxylate anion and how does it affect its acidity?

Answer 7

stabilise the carboxylate anion
increases acidity

Question 8

what Hammett substituent constant (σ) do EWG have?

Answer 8

positive ( σ ) or σ > 0

Question 9

what Hammett substituent constant (σ) do EDG have?

Answer 9

negative ( σ ) or σ > 0

Question 10

which electronic effects do EWG have?

Answer 10

Negative resonance or mesomeric effect (-M or -R) through π-bond and negative inductive effect (-I)

Question 11

which electronic effects do EDG have?

Answer 11

positive resonance or mesomeric effect (-M or -R) through π-bond and positive inductive effect (-I)