Carbohydrates & Glycolysis Flashcards
compounds that differ in configuration around ONLY ONE specific carbon atom with exceptin of the carboxyl carbon
Epimers
compounds that have same chemical formula but different structures
C6H12O6
Isomers
pairs of structures that are MIRROR Image of each other ..
are designated as D-sugar and L-sugar
Enantiomers
sugars are convertible between linear form and ring form
most are in th cyclic or ring form
anomers
can convert spontaneously through process
no need enzyme
mutarotation
transporter in all sugar
facilitated diffusion
GLUT 2
transporter occurs in GUT kidneys
fxn: absorption of Fructose, glucose, galactose
GLUT 5
secondary active transport
Na / hexose symporter
for glucose and galactose
SGLT 1
glycemic index
low glycemic index is beneficial in DM AND DIETING
inc in blood glucose after a test dose of a CHO compared with that after equivalent amt of glucose
tells how fast absorption
example of anabolic - synthesis of compound from smaller raw materials
CHON and triglycerides synthesis, glycogenesis
example of catabolic - breakdown of larger molecules
glycolysis, beta oxidation, glycogenolysis
example of amphibolic
citric acid cycle
second messenger of insulin and growth factor
tyrosine kinase
2nd msgr that activate CHON kinase C and release intracellilar Ca
DAG, inositol triphosphate
Transporter all tissues esp red cell brain
GLUT 1
transporter for brain
GLUT 1 & 3
differentiate 2types of glycolysis
aerobic - cells with mitochondria and adequate O2 supply,
PYRUVATE, ex. resting muscle
anaerobic - cells without ….
LACTATE ex. rbc, exercising muscle cramps…
rate limiting reaction of glycolytic pathway, pace setting enzyme of glycolysis
PFK 1
fxn of PKF 2?
converts F-6-P to F-2,6-BP, activate to enhance PFK 1
is the second most common cause ( after glucose 6 phospate DH deficiency) of enzyme def. related chronic HEMOLYTIC ANEMIA
most common enzyme defect in glycolysis
Pyruvate kinase deficiency
how many net mol. of ATP can be produced from 1 glucose mol. via substrate - level phosphorylation?
2 ATP molecules
in what part of the cell can you find the electron transport chain
inner mitochondrial mem.
activator of PFK 1?
inhibitor?
activator: F 2,6 BP & AMP
inhibitor: ATP & citrate
found in RBC where phosphoglycerate kinase is bypassed,
it is also binds to hgb to let go oxygen. “kabit” to let go oxygen.. higher altitude environment so oxygen will release..
2,3 Bisphosphoglycerate