Capsules Flashcards
are solid dosage forms in which medicinal agents and/or inert substances are enclosed in a small shell of gelatin.
Capsules
The shells may be
composed of two pieces, a ____ and a ____, or
they may be composed of a single piece.
body, cap
Two-piece capsules are commonly referred to as __________, and one-piece capsules are often referred to as _______
hard-shell capsules
soft-shell capsules
are used by community pharmacists in the extemporaneous compounding of prescriptions
Hard Gelatin Capsules
Empty capsule shell are made out of
Water, gelatin and sugar
is obtained by the partial hydrolysis of collagen obtained from the skin, white connective tissue, and bones of animals
Gelatin
Capsules are packaged with these materials—The desiccant materials most often used are dried silica gel,
clay, and activated charcoal
True
Capsule shells are usually made from gelatin; however, they may also be made from __________ or other suitable material.
cellulose polymers
When no deliberate effort has been made to modify the API release rate, they are
referred to as
immediate release.
Gelatin, being a protein, is digested by ___________ and absorbed.
proteolytic enzymes
___________, a noninvasive procedure that entails the use of a gamma ray–emitting radiotracer incorporated into the formulation with a gamma camera coupled to a data recording system
gamma scintigraphy
When scin-
tigraphy is combined with pharmacokinetic
studies, the resultant
evaluation provides information about the transit and drug-release patterns of the dosage form as well as the rate of drug absorption
from the various regions of the gastrointestinal tract ___________
Pharmacoscintography
A separate technique using a pH-sensitive
nondigestible radiotelemetric device termed
the Heidelberg capsule, the approximate size of a No. 0 gelatin capsule, has been used as a nonradioactive means to measure gastric pH, gastric residence time, and gastric emptying time of solid dosage forms in fasting and non-fasting human subject
True
innovation in capsule shell design is the Snap-fit, Coni-snap, and Coni-snap Supro hard gelatin capsules
True
The original _______
construction enables the two halves of the
capsule shells to be positively joined through
locking grooves in the shell walls
Snap-fit
