Capoten (Captopril)

Question 1

Classification

Answer 1

Angiotensin Converting Enzyme Inhibitor (ACE-Inhibitor)

Question 2

Mechanism of Action

Answer 2

• Blocks angiotensin converting enzymes, preventing formation of angiotensin II
• Dilates coronary and systemic arteries
• Decreases peripheral vascular resistance
• Improves cardiac output

Question 3

Indications

Answer 3

• Congestive Heart Failure

Question 4

Contraindications

Answer 4

• Hypotension
• Hypersensitivity
• Pregnancy

Question 5

Adverse Effects

Answer 5

• Cardiovascular: hypotension, chest pain, hyperkalemia
• Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain, loss of appetite
• Neurological: dizziness, headache

Question 6

Administration

Answer 6

• Adult: 25 mg sublingual
• Pediatrics: Safety has not been established.

Question 7

Special Considerations

Answer 7

• When taken with lithium, captopril can increase lithium to toxic levels in the blood.
• Anticancer drugs or chloramphenicol taken with captopril can increase the chance of having a low blood cell count.