CAP1 Flashcards
Which two antipsychotics have the least effect on QTc ?
Aripiprazole and olanzapine
Clonidine is an agonist at what receptor?
alpha 2a 2b 2c
Guanfacine is an agonist at what receptor
alpha 2, primarily 2a
What does marijuana impair?
short term memory, visual motor functioning
What are the side effects of PCP?
agitation, delusions, hypertension, flushing, diaphoresis
What are the consequences of inhalant use?
hearing loss, peripheral neuropathy, CNS brain damage, liver, kidney, bone marrow deterioration
What are the stages of stopping behavior in motivational interviewing?
Pre-contemplation, contemplation, preparation, action
Does anxiety precede substance use disorders or ‘post’cede them?
Likely to precede
What is successful at treating night fears?
Emotive imagery. Children are trained to imagine a super hero
What percent of children have at least one sleep walking episode?
15%
How do yo treat sleep terrors and sleep walking?
Time them and wake 10-15 minutes earlier
What percentage of children 6 to 12 years have nightmares?
20%
A closed head injury leads to what sleep disorder?
Circadian rhythm sleep disorder
By what age should imaginary companions end?
8 years of age
What symptoms might be found in Dissociative Identity Disorder that may overlap with Schizophrenia?
DID remains a controversial diagnosis. Command hallucinations, voices speaking to one another, delusional beliefs, illogical thought patterns, thought blocking. There is a normal range of affect and ability to relate warmly
What is the disease fatality rate for Neuroleptic Malignant Syndrome NMS in children?
9%
Geller’s study of Lithium for BiPD and SUD in adolescents showed what?
Better function on lithium and decreased substance use but no change on manic depression
What did a long-term naturalistic study of BiPD classic and lithium in 59 children over 10 years show?
Effective in 39/59, i.e. 2/3 (DeLong 1987)
Discontinuing lithium makes a difference or no difference in pediatric bipolar disorder?
Relapse more likely (Strober 1990)
What is the mechanism of action of lithium?
Unknown precisely. Affects a number of neurotransmitters and receptors, decreasing norepinephrine release and increasing serotonin synthesis.
What is the mechanism of action of valproate?
Although the mechanism of action of valproate is not fully understood, traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of gamma-aminobutyric acid (GABA).
What is the mechanism of action of topiramate?
Blocks voltage-dependent sodium and calcium channels. It also inhibits the excitatory glutamate pathway while enhancing the inhibitory effect of GABA.
What are the key cognitive side effects of topiramate?
Cognitive blunting and word retrieval difficulties
What is the prevalence of bipolar disorder in adults?
1-2%
What percent of highschoolers have tried drugs or alcohol by 12th grade?
85%
Which persons with alcoholism do worse by Cloninger and Babor’s classification?
Type 2, Type B
Is THC use genetic or environmental?
Experimental use has a more environmental component. Dependence is more likely to have genetic underpinnings
What is the mean elimination half-life of THC?
4 days
What percentage of suicide victims have/had relatives with suicidal tendencies
60% (compared with 12% for non-suicidal teens)
A family history of suicide increases risk of suicide by how much?
5 times for females and 3 times for males
in one study, what percent of children who commit suicide had history of attempt(s)
26-33%
Do LGBTQQIAP youth have an increased risk of suicide?
Yes. Although, sexual identity or orientation per se has likely little to do with the increased risk
What is the suicide rate for youths aged 10 to 18?
5/1000
CDC data has shown what percentage of high school students have had a suicidal idea, a plan, and an attempt in the last year?
17 %, 14%, and 2% respectively
The Youth Risk Behavior Surveillance System showed what percentage of high school youth report rarely or never wearing a seatbelt?
6%
The Youth Risk Behavior Surveillance System showed what percentage of high school students had ridden one or more times during the 30 days before the survey in a car or other vehicle driven by someone who had been drinking alcohol?
Nationwide, 16.5% of students had ridden one or moretimes during the 30 days before the survey in a car or other vehicle driven by someone who had been drinking alcohol
The Youth Risk Behavior Surveillance System showed what percentage of high school students had carried a weapon at least one day in the previous 30 days?
Nationwide, 15.7% of students had carried a weapon (e.g., gun, knife, or club) on at least 1 day during the 30 days beforethe survey
The Youth Risk Behavior Surveillance System showed what percentage of high school students had ever drunk alcohol?
60% ever. 16% before age 13 (more than a few sips). 30% of high school students had had a drink at least one day in the last 30 days.
The Youth Risk Behavior Surveillance System showed what percentage of high school students had used THC?
36%
The Youth Risk Behavior Surveillance System showed what percentage of high school students had texted or e-mailed while driving in the previous 30 days?
40%
The Youth Risk Behavior Surveillance System showed what percentage of high school students had sexual intercourse?
Nationwide, 39.5% of students had ever had sexual intercourse and 9.7% had had sexual intercourse with four or more persons during their life.
The Youth Risk Behavior Surveillance System showed what percentage of high school students in the previous 30 days had not used a condom (they or their partner) in their last sexual intercourse
46%
In a self-report measure of children with depression, what were the top three symptoms?
- Aches and pains 2. Sad affect 3. Helplessness/ hopelessness
What is higher, the number of suicides or homicides?
Homicideses
What is a crisis hotline and text line for suicidal thinking?
Calling: 1-800-273-TALK (8255) Texting: text home to 741741
What percentage of children and adolescents have a second depressive episode within two years after the first remits?
40% within two years, 75% within 5 years
What has been found of mothers of depressed children in their management of their children?
They use more reactive and fewer pre-emptive strategies; reactive strategies predict conduct problems
What are features of children with depression, besides symptoms?
Heightened empathy; misplaced sense of responsibility; unrealistic ideas about helping others
What percentage of high school students report having been bullied in the previous year?
19%
What is the ratio of suicide attemtps to suicide completions in youth?
50:01:00
What percent of suicide victims have had mental health treatment?
30 to 50%
What are the odds ratios of suicide in an adolescent with: 1) a prior attempt 2) major depressive disorder 3) substance use disorder
1) 22.5 for prior SA 2) 8.6 for MDD 3) 7.1 for Sub Use
In interpersonal psychotherapy by Klerman what are the four areas of interpersonal concern?
- interpersonal deficits 2. interpersonal role conflicts 3. abnormal grief 4. role transitions. A modification for adolescents is single parent families
The Youth Risk Behavior Surveillance System showed what percentage of high school students reported feeling felt so sad or hopeless almost every day for 2 or more weeks in a row that they stopped doing some usual activities?
31.50%
What are the elements of problem-solving?
- Problems are part of everyday life; inhibit impulse to avoid 2. Formulate problem into a workable problem and goals 3. Generate alternative solutions 4. Evaluate them and implement one 5. Verify the merit/outcome of the chosen solution  
What are two types of cognitive dysfunction?
- Deficiency 2. Distortion
What does “cognitive structures” refer to?
AKA cognitive schemata. Refers to memory principally–information that is internally represented in memory. Cognitive content is the information actually represented (self talk). Cognitive processing refers to how we go about perceiving and interpreting experience. Cognitive products (attributions) is a result of the interaction of the above
Does psychotherapy work?
In a meta-analysis of 100 studies Weisz 1987 found an effect size of 0.79 for all therapies combined
What percentage of adolescents will have a depressive episode by age 18?
20%
Where do most adolescent suicides occur?
After school hours and in a teen’s home; most are precipitated by an interpersonal conflict
What time do most adolescent suicides occur?
Late afternoon, early evening
What precipitates suicide attempts in adolescents?
Family fight, parent-child discord, lower grades, long absence from school
What is the presumed lifetime risk of a mood disorder if both parents have mood disorders in their sides of the family?
100%; 24% if one parent’s family; 17% if no extended family has a mood disorder
In one study, what percentage of children who were depressed and hospitalized were re-hospitalized within two years of first hospitalization?
80%
In Emslie’s study of depression in children and adolescents, what percentage who responded had a clinical global impression (CGI) score of 1 or 2 for fluoxetine and placebo, respectively?
56% for fluoxetine and 33% for placebo (CGI 1 = very much, 2 = much improved)
What are the key ‘rhythmic’ interventions in bipolar disorder?
Sleep and regular daily activities
What therapy has been shown to reduce suicidal behavior in adults?
Dialectical behavior therapy (DBT)
A history of sexual abuse increases the risk of a suicide attempt by how much?
8
Do suicide prevention telephone interventions seem to help reduce suicidality?
Yes with a small positive effect
What is the point prevalence of schizophrenia in 2 to 12 year olds?
2/100,000
What are some premorbid findings in schizophrenia?
Language development, speech and learning disorders, disruptive behaviors
What is the age of onset for schizophrenia
Rare before age 9. Less than 1% have it before age 13; less than 10% have it before age 15; the rest are diagnosed above 16 years of age
What percentage of children with schizophrenia have visual hallucinations?
Close to 100%
What did a group with childhood onset schizophrenia studied by Eggers 1978 and 1989 show about outcome?
20% showed remission, 30% had satisfactory social adaptation, 50% remained impaired
When was depression in children and adolescents first recognized in the US?
The first official recognition occurred at an NIMH conference in 1975. (In part, prior to this, psychodynamic ideas about superego and ego formation precluded the ideas of depression in children.)
Emil Kraepelin found what percentage of persons with mania had an onset before 10 years of age?
0.40%
What percentage of children have atypical depression?
16.50%
The age of onset of depression is associated with duration or recovery?
Duration
What findings are there for cortisol and growth hormone in children with depression?
Cortisol hypersecretion and blunting of nocturnal growth hormone
What is the tricyclic antidepressant response compared to placebo in child and adolescent depression?
The same, a 50% response for both
What percentage of adolescents present with depressed mood as the index episode in bipolar disorder?
60%
What percentage of child and adolescent patients with bipolar disorder have ADHD? 
57 to 98% (Geller, Wozniak)
What is the concordance rate for depression in monozygotic and dizygotic twins, respectively?
54% MZ, 24% DZ
What is the concordance rate for bipolar disorder in Monozygotic and dizygotic twins, respectively?
65% MZ, 14% DZ
What is the ‘cognitive triad’ in depression?
Pessimistic and deprecatory about: 1) oneself 2) one’s experience, and 3) the future
What lab tests might be obtained before lithium use?
Renal and thyroid function, calcium leve. Others include a CBC with differential since a slight leukocytosis can occur
What is the risk of schizophrenia if one parent has schizophrenia?
10 to 15%
Is there an association between temporal lobe epilepsy (TLE) and the development schizophrenia?
One study showed 10% of children with TLE developed SZP
What is found in the conversational language of patients with schizophrenia?
They use fewer linguistic cohesive devices
What structures of the brain are reduced in schizophrenia?
Frontal-temporal area (the ventricles are increased)
When depressed, what percentage of adolescents would meet criteria for a personality disorder?
60%, i.e. about 2/3. 30% of these are for BPD. After the remission of the depression the PD symptoms are no longer evident
After a depressive episode in children and adolescents, do social skills deficits and psychological morbidity persist?
Yes
What are some elements of ‘pragmatic language’?
Conventions for eye contact, gestures, verbal and non-verbal cues, sustaining conversation, maintaining a shared topic, taking turns in dialogue
Does a Jehovah’s Witness practitioner have the right to refuse a blood transfusion for their child?
No
What percent of divorces have custody issues and conflicts arise?
<10%. 1.5% need to rely on a judge. When conflict is present 75% of families have little conflict; 25% have severe conflict