CAP1 Flashcards
Which two antipsychotics have the least effect on QTc ?
Aripiprazole and olanzapine
Clonidine is an agonist at what receptor?
alpha 2a 2b 2c
Guanfacine is an agonist at what receptor
alpha 2, primarily 2a
What does marijuana impair?
short term memory, visual motor functioning
What are the side effects of PCP?
agitation, delusions, hypertension, flushing, diaphoresis
What are the consequences of inhalant use?
hearing loss, peripheral neuropathy, CNS brain damage, liver, kidney, bone marrow deterioration
What are the stages of stopping behavior in motivational interviewing?
Pre-contemplation, contemplation, preparation, action
Does anxiety precede substance use disorders or ‘post’cede them?
Likely to precede
What is successful at treating night fears?
Emotive imagery. Children are trained to imagine a super hero
What percent of children have at least one sleep walking episode?
15%
How do yo treat sleep terrors and sleep walking?
Time them and wake 10-15 minutes earlier
What percentage of children 6 to 12 years have nightmares?
20%
A closed head injury leads to what sleep disorder?
Circadian rhythm sleep disorder
By what age should imaginary companions end?
8 years of age
What symptoms might be found in Dissociative Identity Disorder that may overlap with Schizophrenia?
DID remains a controversial diagnosis. Command hallucinations, voices speaking to one another, delusional beliefs, illogical thought patterns, thought blocking. There is a normal range of affect and ability to relate warmly
What is the disease fatality rate for Neuroleptic Malignant Syndrome NMS in children?
9%
Geller’s study of Lithium for BiPD and SUD in adolescents showed what?
Better function on lithium and decreased substance use but no change on manic depression
What did a long-term naturalistic study of BiPD classic and lithium in 59 children over 10 years show?
Effective in 39/59, i.e. 2/3 (DeLong 1987)
Discontinuing lithium makes a difference or no difference in pediatric bipolar disorder?
Relapse more likely (Strober 1990)
What is the mechanism of action of lithium?
Unknown precisely. Affects a number of neurotransmitters and receptors, decreasing norepinephrine release and increasing serotonin synthesis.
What is the mechanism of action of valproate?
Although the mechanism of action of valproate is not fully understood, traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of gamma-aminobutyric acid (GABA).
What is the mechanism of action of topiramate?
Blocks voltage-dependent sodium and calcium channels. It also inhibits the excitatory glutamate pathway while enhancing the inhibitory effect of GABA.
What are the key cognitive side effects of topiramate?
Cognitive blunting and word retrieval difficulties
What is the prevalence of bipolar disorder in adults?
1-2%