CAP BOARDS 2 Flashcards
Beta-2 agents and mixed beta-1/beta-2 agents (non selective) such as propranolol will induce what in asthmatic patients?
bronchospasm
Sexual orientation may be a more stable trait in males or females?
males
Most common inherited cause of ID in males?
Fragile X
what are early signs of autism? (4)
1) absence of social smile by 6 mo of age
2) not babbling or pointing by 12 mo
3) not using single words by 16 mo
4) unable to use 2-word phrases
Results of the TEOSS (Early Onset Schizophrenia Spectrum Disorders Study)?
< 50% of patients responded over 8 wks of tx
All tx arms were equally efficacious (risperidone, olanzapine, and molindone)
There were no differences in EPS in the tx arms, but this result was likely influences by the ppx use of cogentin in the molindone group
The neurotransmitter principally affected by fluvoxamine is produced in what brain region?
Raphe nuclei (serotonin)
Norepinephrine is produced where?
Locus coeruleus
What neurotransmitter is produced in the locus coeruleus?
Norepinephrine
What neurotransmitter is produced in the raphe nuclei?
Serotonin
Where is serotonin produced?
Raphe nuclei
Ach is produced where?
Nucleus basalis of Meynert
What is produced in the nucleus basalis of Meynert?
Ach
Where is histamine produced?
Tuberomammillary nucleus
What is produced in the tuberomammillary nucleus?
Histamine
Where is dopamine produced? (2)
Substantia nigra and VTA
What neurotransmitter is produced in the substantia nigra and the VTA?
Dopamine
Risperidone has FDA approval for agitation in autism - age range?
5-16
Risperidone has FDA approval for the tx of schizophrenia - age range?
13-17
Risperidone has FDA approval for the tx of bipolar d/o - age range?
10-17
The ionic gradient necessary for a neuron to generate action potentials is established the distribution of what three ions and how?
K+, Cl-, Na+
High concentrations of Na+ and Cl- outside the cell membrane and high concentrations of K+ inside the cell membrane
At rest, K+ and Cl- channels are open so that K+ and Cl- gradients determine the membrane’s resting potential, which is negative by about -50mV to -75mV. Once depolarized beyond the cell’s threshold potential, voltage-gated Na+ channels open rapidly, depolarizing the membrane. The membrane potential shifts to +50mV quickly.
16 month child is sitting with his mother in a room, then walks over to the doorway. he walks just outside the door, looks back at his mother, and begins to cry. It seems as if he wants to explore the next room but is uncertain about leaving his mother. According to Mahler, this child is most likely in which developmental sub-phase?
Rapprochement (15-24 months).
According to Mahler, when does hatching occur?
5-9 months. The infant becomes aware that he/she is separate from the mother, notices surroundings, but still uses the mother as the primary reference point for understanding the world.
According to Mahler, when does practicing occur?
9-16 months, the infant can physically move about alone
MMPI-A can be used in what age range?
14-18.
If a patient is already taking valproate, what is the ideal lamotrigine dose?
Initial dose should be divided to half of the normal dose then increased to a therapeutic dose gradually.
According to the AACAP Practice Parameters for Cultural Competence, it is more common for minority children and adolescents to engage in mental health care after referral from the court or school for disruptive bx. TRUE or FALSE?
TRUE
According to the AACAP Practice Parameters for Cultural Competence, non-hispanic white families are ?x more likely to seek mental health care for their children compared to minority families?
2x
School administrators want to create a behavioral intervention plan for an aggressive student. What is the first major step in creating this plan?
Functional behavioral analysis (FBA) - systematic method for describing a problem behavior and identifying “antecedent and consequent events” that cause or contribute to the bx.
Abilify is approved to tx irritability in kids with autism - what age range?
6-17
a 16M discusses sexual fantasies towards an older cousin during the course of psychotherapy. Which principal justifies leaving out a more descriptive account of the adolescent’s sexual fantasy?
Nonmaleficience, do not harm. It includes not causing physical pain or emotional suffering or depriving others of beneficial things.
A recent study found that children with which gene’s variant allele were more likely to become violent and antisocial adults following child abuse?
MAO-A
According to the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial, after failing a trial of an SSRI, what is the next step?
SSRI or venlafaxine, but venlafacine had more side effects (so the answer is SSRI :)
What group did the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial look at?
adolescents that had not responded to a previous 2-month course of an SSRI
What medications were looked at in the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial? (4)
Paroxetine, citalopram, fluoxetine, and venlafaxine
In the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial, patient who switched to another medication and added CBT had a response rate of?
55% (in comparison to 41% who did not add CBT)
In the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial, those who switched to another medication (and did not add CBT) had a response rate of?
41% (in comparison to 55% w CBT)
Did the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial exclude patients who endorsed SI?
No.
The Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial did not exclude patients who endorsed SI. Did the medications reduce SI?
No
In the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial, what side effects were seen with venlafaxine?
Skin infections and cardiovascular side effects
In the Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial adolescents with a history of what four things were less likely to respond to tx? (4)
1) Chronic depression
2) Severe hopelessness
3) Self-harm bx
4) Family conflict
A 12 month old child has begun to walk and moves around the room, still preferring close contact with the mother at all times. According to Mahler, this child is most likely in which developmental sub-phase?
Practicing (9-16 months). The infant can physically move about alone.
What protocol is used for therapy tx with adolescents experiencing PTSD and concurrent substance use?
Seeking safety
17M is brought to the hospital for hallucinations and bizarre bx. He is screaming that his abdomen hurts. The nurses report that his urine has an unusual color. Dx?
Acute intermittent porphyria
Psychosis + abdominal pain + purple urine. Dx?
Acute intermittent porphyria
3 sxs of Acute intermittent porphyria?
Psychosis + abdominal pain + purple urine
What is Acute intermittent porphyria?
Rare autosomal dominant disease that affects heme production resulting from a deficiency of the porphobilinogen deaminase.
The exact mechanism of acute attacks not clear. The most favored hypothesis is that porpholobilinogen buildup causes a toxic effects on neurons.
What cell types produces myelin in the CNS?
Oligodendrocytes.
They are also a type of glial cell.
Macroglia are divided into what 5 types?
1) astrocytes
2) oligodendrocytes
3) ependymal cells
4) radial glia
5) Schwann cells
Astrocytes are a type of macroglia - function?
Form biochemical support of endothelial cells that form the blood-brain-barrier, provide nutrients to CNS, maintain ion balance, and play a role in the repair and scarring process of the brain and spinal cord
Oligodendrocytes are a type of macroglia - function?
Insulate axons in the CNS by providing myelin sheath
Ependymal cells are a type of macroglia - function?
Line the ventricles and are part of CSF production
Radial glia are a type of macroglia - function?
Primary progenitors capable of becoming neurons, astrocytes, and oligodendrocytes that also serve as a scaffold upon which newborn neurons migrate
Schwann cells are a type of macroglia - function?
Myelinate nerves in the PNS (oligodendrocytes are in the CNS)
Nonfunctional or reduced function alleles occur in approx 25-30% of Caucasians, resulting in about what percentage of the population having the phenotype associated with abnl metabolism? (CYP2D6)
5-10%
Atomoxetine is affected by which CYP?
2D6
When is the best time to measure plasma levels of lithium during therapy?
12 hours after the last dose
Which law in the US sets forth the basic requirements for an IEP?
Individuals with Disabilities Education Act
The Higher Education Act of 1965 was intended for what?
To strengthen the educational resources of our colleges and universities and to provide financial assistance for students in post-secondary and higher education. It increased federal money given to universities, created scholarships, gave low-interest loans for students, and established a National Teachers Corps
Section 504 is part of what Act?
Rehabilitation Act of 1973 that prohibits discrimination based upon disability. Section 504 is an anti-discrimination civil rights statute that requires the needs of students with disabilities to be met as adequately as the needs of the non-disabled are met.
What percent of patients with autism have Fragile X?
3-5%
What is the most common genetic cause of ID in boys?
Fragile X
What is the most common genetic cause of ID?
Down syndrome
What is imprinting?
A gene is silenced or otherwise altered by one parent, which can influence the offspring (Prader-Willi or Angelman)
What is anticipation?
Genetic syndrome that appears to become more pronounced with successive generations. (Fragile X)
Example of anticipation?
Fragile X.
Genetic syndrome that appears to become more pronounced with successive generations.
Method of training by which successive approximations toward a target bx are reinforced
Shaping
Learning process in which an innate response to a potent stimulus comes to be elicited in response to a previously neutral stimulus
Classical conditioning
Type of learning in which the strength of a bx is modified by its consequences, such as reward or punishment
Operant conditioning
Walks, puts a block in a cup, drinks from a cup, and says “mama” and “dada” specifically - age?
1 year
17M w reddened conjunctivae, speaking in hushed tones and has tachycardia and a dry mouth. The patient’s parents are worried about his grades at school, but he says he has “got it all figured out.” Which drug is responsible for his sxs?
Cannabis
also causes paranoia and a slowed sense of time
Vertical nystagmus is pathognomonic for what?
PCP intoxication
Paranoia, hallucinations, aggression, and vertical nystagmus - drug?
PCP
HTN, anxiety, and diaphoresis - drug intoxication?
Cocaine
MRI shows large tumors on both VIII cranial nerves. Which syndrome is this child most likely to have?
NF2 (acostic neuromas)
MRI shows large tumors on both VIII cranial nerves. Which syndrome is this child most likely to have? inheritance patterN?
NF2 (acostic neuromas)
Autosomal dominant
Large spots on the skin (cafe-au-lait-spots), optic gliomas, pigmented raised spots on the iris. Which syndrome is this child most likely to have?
NF1
Large spots on the skin (cafe-au-lait-spots), optic gliomas, pigmented raised spots on the iris. Which syndrome is this child most likely to have? Inheritance pattern?
NF1
Autosomal dominant
What concept was developed by Bowlby?
Attachment theory
Multisystemic therapy (MST) is used for what dx?
Conduct disorder
MST is an intensive family and community-based tx for serious juvenile offenders with possible substance abuse issues and their families. The
What are the primary goals of MST?
Decrease youth criminal bx and out-of-home placements.
Indicated for kids w conduct disorder
Testing for Fragile X syndrome involves what method?
PCR (# of CGG repeats) followed by Southern Blot (used to distinguish large pre-mutations from full mutations and to measure the degree of methylation of the FMR1 gene
A young child is evaluated for ID. His parents note that he frequently attempts to bit and scratch himself, often leaving serious woulds on his arms. They recall having an abnormal genetics evaluation. At that time, they were advised to feed him a special diet. Dx?
Lesch-Nyhan disease
Caused by a mutation on the X chromosome. It causes a build up of uric acid in the body.
It can partially be compensated for with a diet limiting the uric acid production
A young child is evaluated for ID. His parents note that he frequently attempts to bit and scratch himself, often leaving serious woulds on his arms. They recall having an abnormal genetics evaluation. At that time, they were advised to feed him a special diet. Caused by a mutation on what?
Lesch-Nyhan disease
Caused by a mutation in the HGPRT gene located on the X chromosome. It causes a build up of uric acid in the body due to the HGPRT deficiency.
It can partially be compensated for with a diet limiting the uric acid production
A young child is evaluated for ID. His parents note that he frequently attempts to bit and scratch himself, often leaving serious woulds on his arms. They recall having an abnormal genetics evaluation. At that time, they were advised to feed him a special diet. Causes what?
Lesch-Nyhan disease
Caused by a mutation on the X chromosome. It causes a build up of uric acid in the body.
It can partially be compensated for with a diet limiting the uric acid production
A former patient’s father has difficulty paying off their bill and offers his construction services (he is a contractor). In what situation would this exchange be considered ethical?
As long as the work is at fair market value
A 16M 2nd generation Mexican American is brought by his parents under court order for a psychiatric evaluation stemming from gang involvement. The patient reports that his grandparents were just “stupid farmers” and “did not understand the world.” He also remarks that “Americans just care about money, and we (the gang) actually care about each other.” Define.
Negative identification: form of marginalization where the youth is openly hostile towards both cultures and may adopt gang culture.
Represented by rejection of the host culture and remaining bound to an “ethnic enclave.”
Separation
Involves a separation from both cultures and some degree of ethnic identity diffusion.
Marginalization
What value tells how likely the result of a study was due to random chance?
P value
What does P = 0.01 mean?
That there is a 1 in 100 probability that the positive results of the study were due to chance, rather than due to a real effect of the drug
What is absolute risk reduction and how is it calculated?
The difference between the risk of an outcome in the exposed group and the unexposed group.
Mathematic inverse of NNT = control event rate - experimental event rate
NNT = 1 / (control event rate - experimental event rate)
A well-designed randomised controlled trial in children with a particular disease found that 20 per cent of the control group developed bad outcomes, compared with only 12 per cent of those receiving treatment. ARR?
20%-12% = 8%
If 100 children were treated, 8 would be prevented from developing bad outcomes.
NNT = 100/8 = ~13. The NNT for one child to benefit is about 13.
A well-designed randomised controlled trial in children with a particular disease found that 20 per cent of the control group developed bad outcomes, compared with only 12 per cent of those receiving treatment. ARR?
20%-12% = 8%
If 100 children were treated, 8 would be prevented from developing bad outcomes.
NNT = 100/8 = ~13. The NNT for one child to benefit is about 13.
A well-designed randomised controlled trial in children with a particular disease found that 20 per cent of the control group developed bad outcomes, compared with only 12 per cent of those receiving treatment. NNT?
20%-12% = 8% = ARR
If 100 children were treated, 8 would be prevented from developing bad outcomes.
NNT = 100/8 = ~13. The NNT for one child to benefit is about 13.
What is the leading known cause of ID?
Fetal alcohol syndrome
What is a potential side effect of atomoxetine that affects males only?
Priapism.
What % of study subjects with ADHD responded preferentially to 1 of 2 classes of stimulants (methylphenidate vs amphetamine)?
44%
What is the initial response rate to stimulants if both stimulant classes are tried (methylphenidate and amphetamine)?
85%
A 16M suffering from acute mania and psychosis presents to the ED. The patient is agitated and demands to leave. The psychiatrist gives IM Haldol. Which ethical principal is working here?
Beneficience
Runs, stacks 4 blocks, removes garments, says at least 6 words. Age?
18 months
What is the correct sequence of infant development as described by Margaret Mahler? (3)
1) Autistic phase (1st few weeks of life)
2) Symbiotic phase (until 5 months of age, recognizes mother but lacks a sense of individuality)
3) Separation-individuation phase
- hatching (increased interest in the outside world)
- practicing (9-16 months, developing the physical ability to separate from mother)
- rapproachement (15-24 months, exploring the outside world but needing mother to be present and offer support)
A child is noted to believe in strict rules and is unable to appreciate any exceptions or nuances to rules, such as the mindset of the person or the situation which the person was facing that the time. Which stage of cognitive development is the child most likely at?
Preoperational (concrete in their thinking, will often adopt a rigid belief in rules, and will fail to understand exceptions or motives behind possibly needing to break the rules.
Age 2-7
A child is noted to believe in strict rules and is unable to appreciate any exceptions or nuances to rules, such as the mindset of the person or the situation which the person was facing that the time. Age?
Preoperational (concrete in their thinking, will often adopt a rigid belief in rules, and will fail to understand exceptions or motives behind possibly needing to break the rules.
Age 2-7
9M is treated for depression. He is American born, but his family is originally from Ecuador. He is generally a good student, but this year his grades have suffered. His mother has a h/o depression that reportedly has responded well to tx with fluoxetine. Of note, the patient is a poor metabolized of fluoxetine. What is the primary consideration when dosing fluoxetine for this boy?
size.
Dosing medication in older children and adolescents mainly relies on differences in body size between child and adults. Fluoxetine is FDA approved for the treatment of depression in children 8 years old +.
Approx what percentage of patients with chronic alcohol use disorders have at least one parents with chronic alcohol use disorder?
30%
16M expresses resentment towards having to care for his younger child. When he is w his friends, he consistently reports how wonderful it is to be a father. At times, he worries about his capabilities and is concerned that he will not be able to provide for his child. Defense mechanism?
Reaction formation: conversion of unconscious wishes into their opposites.
The bx is the opposite of what one really desires or feels.
The unconscious modeling of one’s self after another person’s character and bx
Identification
Ensures that what is unacceptable to the conscious mind, and would if recalled arouse anxiety, is prevented from entering into it.
Repression
Shift of a sexual or aggressive drive to a more acceptable target
The mind substitutes either a new aim or a new object for goals felt in their original form to be dangerous or unacceptable.
Displacement
Separation of a cognitive process from the affect that is associated with it
Isolation of affect
Wilson’s disease - inheritance pattern?
autosomal recessive
A family h/o sleepwalking or sleep terrors is reported in up to what percentage of patients with sleepwalking disorder?
80%
Severe side effects of ecstasy abuse and intoxication? (7)
1) Coagulopathy
2) Acute renal failure
3) Hepatotoxicity
4) Rhabdomyolysis
5) Death
6) convulsions
7) body temp dysregulations
Common side effects of MDMA?
1) PMR
2) increased sexual response
3) bruxism
4) trismus
5) anorexia
6) sweating
A group of 3.5 y/o children are playing in a sandbox with the same toys. What kind of play behavior are they most likely to exhibit?
Associative play: (around 3 years old)
Individual play starts to overlap. They share the same toys but will still play separately
What type of play is commonly seen with 4 y/os.
Cooperative play. Children play with toys and interact with each other.
At what age do you commonly see parallel play?
2 y/o
Parallel, associative, and cooperative play are the progressive stages of play during what Piaget development period?
Preoperational (preschool age)
Rash w facial involvement, mucus membrane involvement, fever, and lymphadenopathy after lamotrigine is a sign of what?
SJS
Lamotrigine overdose can be fatal. The most common sxs include stupor, convulsions, and intraventricular delay. Tx?
Supportive
A cohort study was designed to examine the Development of MDD in children of divorced parents vs married parents. What measure should the researchers use to express the probability of an event occurring when comparing an exposed group to a non-exposed group.
Relative risk. Expresses the probability of an event occurring when comparing an exposed and a non-exposed group (incidence of exposed over incidence of unexposed). It is used in RCT and cohort studies.
Used to calculate risk in a case-control study and signifies the odds of having a disease given an exposure (odds of disease with exposure over odds of disease without exposure).
Odds ratio.
For rare diseases, the odds ratio approximates what?
Relative risk
Calculated as the # of events over the number of subjects. It is used to calculate several measures, including relative risk and absolute risk reduction.
Event rate
Similar to relative risk (expresses the probability of an event occurring when comparing an exposed and non-exposed group), but while relative risk ratios are cumulative over the course of a study, this ratio reflects the instantaneous risk over a specific time period. It is helpful when 2 groups are experiencing events at different rates, even if the overall event rate may be similar.
Hazard ratio
17F c/o recent episodes of extreme anxiety, racing pulse, and cold sweats. Her urine vanillyl mandelic acid is elevated. What neurotransmitter is produced in excess?
Norepinephrine
pheochromocytoma
17F c/o recent episodes of extreme anxiety, racing pulse, and cold sweats. Her urine vanillyl mandelic acid is elevated. A neurotransmitter is produced in excess - where is it produced?
Norepinephrine - pheochromocytoma
17F c/o recent episodes of extreme anxiety, racing pulse, and cold sweats. Her urine vanillyl mandelic acid is elevated. Dx?
pheochromocytoma
17F c/o recent episodes of extreme anxiety, racing pulse, and cold sweats. Her urine vanillyl mandelic acid is elevated. Where might you see a mass?
pheochromocytoma
– usually see an adrenal mass
In structural family therapy, the therapist first “joins” the family in order to observe what is occurring. After joining, which technique does the therapist typically use next?
Mapping: the therapist makes an assessment of the family’s structure and repetitive patterns of interactions, usually looking for the maladaptive patterns that need to be addressed during restructuring
What are the three phases of structural family therapy?
1) Joining
2) Mapping
3) Restructuring
What kind of scheduling is a casino using to encourage this gambling bx?
Variable ratio. This schedule provides reinforcement at a varying response rate. The number of game attempts to win at slots varies for each win.
(a variable interval schedule provides reinforcement for responses that occur after varying amts of time)
A 4 y/o child presents for an initial evaluation with a h/o of school refusal. Which broad-based rating scale is best suited to evaluate anxiety?
Spence Children’s Anxiety Scale (normed to the age of 2.5, parent report from age 2.5 - 6) and consists of 35-45 items geared towards assessing anxiety.
Age range for the SCARED?
8-18. Looks at GAD, social phobia, panic d/o, and separation anxiety.
36-item scale used to assess intensity and frequency of aggression and externalizing bxs as well as sxs of ADHD in children age 2-16. This scale was utilized to measure outcomes in PCIT.
Eyeberg Child Bx Inventory (ECBI)
Eyeberg Child Bx Inventory (ECBI) = 36-item scale used to assess intensity and frequency of aggression and externalizing bxs as well as sxs of ADHD in children age Range? This scale was utilized to measure outcomes in PCIT.
2-16
This type of aggression is a marked and pervasive tendency to perceive that others are acting with hostile intent. It is typically a result of an angry arousal and is impulsive in nature.
Reactive aggression.
Reactive aggression = This type of aggression is a marked and pervasive tendency to perceive that others are acting with hostile intent. It is typically a result of an angry arousal and is impulsive in nature. Tx?
Anger management
This type of aggression is rooted in a belief that the youth will get what he/she wants and that other strategies will not work. It is deliberate.
Proactive aggression
Proactive aggression = This type of aggression is rooted in a belief that the youth will get what he/she wants and that other strategies will not work. It is deliberate. Tx?
Therapeutic modalities that enhance empathy and decrease antisocial attitudes.
Primary enuresis - there is a high rate of spontaneous remission when?
Between ages 5-7 and after age 12
What gene is associated with tuberous sclerosis and is linked to ASD?
TSC1
Medical conditions that cause ASD can be identified in what percent of cases?
<5%
What percent of children with severe chronic medical illness survive into adulthood?
90%
What features need to be present at some point to dx Tourette’s disorder?
Multiple motor tics and at least 1 vocal tic
Must be present at some time during the illness, although not necessarily concurrently. 1 year. No tic free period of more than 3 consecutive months.
Onset of Tourette’s disorder must occur before what age?
18 years
Who was the first person to characterize autism spectrum?
Leo Kanner
What part of the brain is responsible for arousal?
Pons
What part of the brain is responsible for most physiologic regulations, including body temperature?
Hypothalamus
Language is controlled by several areas of the brain, including what two lobes?
frontal and temporal
A child can hold her head up when sitting in a chair but cannot sit up on her own on the ground. The child will turn and look at sounds but does not yet say any sounds or words other than cooing. She has just started to reach for objects but is unable to pass them back to her parents. Age?
4 months but not quite 6 months (being unable to sit unsupported is the most common indicator).
MOA of mirtazapine?
Antagonism of presynaptic alpha-2-adrenergic inhibitory autoreceptors = noradrenergic and serotonergic activity.
Bioavailability of mirtazapine?
50% d/t extensive first-pass metabolism.
Common side effects of mirtazapine? (6)
1) mildly elevated ALT and triglycerides
2) weight gain
3) somnolence
4) dry mouth
5) asthenia
6) constipation
Telencephalon (3)?
1) Cerebral hemispheres
2) Limbic system
3) Basal ganglia
Diencephalon (3)?
1) Thalamus
2) Hypothalamus
3) Optic vesicle
Mesencephalon (3)?
1) Red nucleus
2) Substantia nigra
3) Periaqueductal gray
Melencephalon (2)?
1) Pons
2) Cerebellum
Myelencephalon (1)?
Medulla
A 6 y/o is struggling to make new friends and reports to his mother that he “can’t do anything right.” Which basic conflict describes this child?
Industry vs inferiority (6-12)
Confidence, competence, social skills
In what age group do you see trust vs. mistrust?
Birth to 18 months
Basic trust
In what age group do you see autonomy vs shame?
18 months to 3 years
Control and independence
In what age group do you see initiative vs guilt?
3 to 6
taking control of the environment, purpose
In what age group do you see identity vs role confusion?
12 to 28
Formation of identity, devotion
Pica = repeated eating of nonfood substances that are not nutritional for at least how long?
1 month
During a family therapy session, the therapist asks the family members to get up and stand physically closer to family members who they felt emotionally closer to and stay distant from those they felt emotionally distant from. This is an example of which technique?
Sculpting
First line medication for moderate - severe tics?
Guanfacine or clonidine
Antipsychotics are second line
Patients with this personality disorder commonly experience over-involvement and intrusive bx by primary caretakers as a child. They were often socially humiliated during childhood, which leads to doubt in their own ability to function independently of others.
Dependent personality disorder
Patients who develop this personality disorder often had parents who were emotionally withholding and overprotective or over-controlling. The were often punished and rarely rewarded. They developed sxs as a strategy to avoid punishment.
OCPD
A grandiose sense of self-importance is a sx of what personality disorder?
Narcissistic PD
A referral to a child psychiatrist is a typical component of an IEP - TRUE OR FALSE?
FALSE
LOT benzos are metabolized by the liver, but primarily via what mechanism?
Conjugation
A transition plan is a part of an IEP that help with the transition from HS to adulthood. The transition plan starts at what age?
16
Common sleep disorder in teens?
Circadian rhythm disorder, delayed-phase type
Children and adolescents dx’d with anxiety disorders are how many more times likely to develop a depressive or anxiety disorder in adultlhood?
2-3x more likely
At any time, what % of adolescents report some degree of SI?
15-25%
What percent of teens attempt suicide?
1-10%
Suicide is the 2nd leading cause of death in adolescents and accounts for what % of all deaths?
11
22q11.w is associated with a higher risk of early onset schizophrenia. What is the syndrome?
Velocardiofacial
Early onset schizophrenia - lifetime risk of developing the illness is ?x higher in first-degree relatives of affected probands?
5-20x
A 7 y/o female enjoys forming clubs with other girls, making shared rules, and collecting dolls. Erickson stage of development?
Industry vs Inferiority
An 8 y/o girl is working with her mother, who pours a container of lemonade into 2 differently shaped glasses that hold the same volume The child correctly recognizes that although the glasses are different shapes they hold the same volume. Piaget phase?
Concrete operational (7-11 years old)
Piaget stage, starts at age 11, includes the use of abstract and hypothetical thinking. The ability to discern major principals and motivations of ideas, theories, or actions allows individuals in this stage to apply them to new and similar situations.
Formal operations
Irritability and aggression occur more frequently in bipolar patients with comorbid ADHD when tx’d with stimulants - true or false?
TRUE
What medical condition is common in patients with Down Syndrome and may mimic depression?
Hypothyroidism
Patients with down syndrome often experience dementia at what age?
40s and 50s
ID is generally profound in down syndrome -true or false?
FALSE - can be variable
Which model of family therapy is most concerned with triangulation?
Transgenerational family therapy is primarily concerned with helping an individual to differentiate themselves from the family.
What is often used in transgenerational family therapy?
Genograms.
Transgenerational family therapy is primarily concerned with helping an individual to differentiate themselves from the family.
What is triangulation?
When 2 family members join together in opposition to another. It is tx’d with tansgenerational family therapy, which is primarily concerned with helping an individual to differentiate themselves from the family.
Is light therapy considered an effective tx?
YES.
Light therapy carries a risk of activating patients with what dx?
It carries a risk of activating patients with bipolar disorder.
What is the most characteristic primitive defense mechanism in OCD?
Undoing: an attempt to undo or somehow reverse an unacceptable thought, feeling , or action that already occurred by doing an opposite bx.
Ex: washing hands multiple times after having an “unclean” thought. By going back and undoing the past, the anxiety over a bx is avoided.
A child in the preoperational stage bumps his knee against a desk and kicks the desk, accusing it of hurting him. What is this called?
Animism: the attribution of a soul to plants, inanimate objects, and natural phenomena. The child is egocentric and assumes all of the world thinks as he/she does, including inanimate objects.
Most sxs of acute stress will dissipate within 1 month following a tragedy - what % of children will continue to have sxs after a month?
30%
What is the general natural history of Tourette’s syndrome?
Peaks at age 12 and then improves
Tourette’s resolves by age 18 in about what % of children?
50%
Tourette’s syndrome occurs in about what percent of children?
0.5%
Tourette’s syndrome affects males more than females by a ratio of?
4:1
What mood stabilizer slows cardiac conduction and should be avoided in patients with high-grade atrioventricular block and sinus syndrome?
Carbamazepine
SIADH and hyponatremia can occur with which mood stabilizer?
Carbamazepine
Norfluoxetine, the metabolite of fluoxetine has a half life of up to how many days?
16
Fluoxetine is what percent protein bound?
94.5%
Why is fluoxetine contradindication within 5 weeks of thioridazine use?
QTc prolongation
Fluoxetine dosing for young children?
5 mg/day, 10 mg/day for older children
Form of encouragement that is used to convey the therapist’s high level of confidence in a patient
Exhortation
MOA for which mood stabilizer - inhibits glutamate and voltage-gated sodium channels
Lamotrigine
What mood stabilizer increases GABA in the brain?
Depakote
Which mood stabilizer exerts its effects through the inhibition of voltage-dependent sodium channels and presynaptic sodium channels
Carbamazepine
How does the response to ECT vary between adolescents and adults?
Response appears to be similar
Before ECT is used, what needs to happen?
2 child and adolescent psychiatrists who are not the primary caregivers for the adolescent should be consulted and should agree that ECT is indicated
What is the most common genetic cause of ID?
Down Syndrome
(Fragile X is the most common genetic cause of ID in boys).
Which gene is associated with developing psychosis after using cannabis?
AKT1
Which gene has been reported to interact with stressful life events and childhood maltreatment in the development of depression?
BDNF
Which gene may sensitive the developing brain to the pathogenic effect of CMV in utero, leading to schizophrenia in adulthood?
CTNNA3
Which gene, that codes a co-chaperone of the glucocorticoid receptor, was reported to sensitize individuals to developing PTSD after exposure to childhood maltreatment?
FKBP5
Which therapy approach to substance abuse in adolescents has the most empirical support?
Family therapy
During the Oedipal phase of development, what is characteristic of play? (4)
1) child’s sense of place within the family
2) theories and feelings about babies and their origins
3) anatomical differences between the genders
4) curiosity and excitement associated with genital sensations
4) competition and rivalry
A RTC is designed to evaluate the relationship between HTN and differing doses of velafaxine. A linear regression model is plotted with venlafaxine on the X-axis and BP on the Y-axis. R is calculated as 0.6. How should the coefficient of determination be interpreted?
36% of variance in BP can be explained by venlafaxine dose. (calculated by the square of the R value).
Variance in Y that can be explained by X.
The TADS study indicated that what percent of depressed youth respond to initial tx w medication?
60%
CBT + meds = 71%
A loaded gun at home confers a ?x higher risk in youth without any psychopathology?
30x
Psychological factors contributing to suicide risk?
1) impulsive aggression
2) hopelessness
3) neuroticism
4) same-sex attraction
patients who have first-degree relatives who have completed suicide have a ?x greater risk for suicide attempt?
4-6x
Genetic factors that elevate risk of suicide? (3)
1) altered serotonergic function
2) altered adrenocortical function
3) blunted sleep-stimulated growth hormone secretion
A white female can throw a ball overhand - this milestone is achieved by 50-90% of children by what age?
24 months
What are the 5 core principles of MI?
1) express empathy
2) develop discrepancy
3) avoid argumentation
4) roll w resistance
5) support self-efficacy
Those suffering from this condition have delayed motor development, jerky limb movements, epilepsy, face abnormalities, happy demeanor, and laugh frequently.
Angelman syndrome (maternal ch. 15)
Approx what % of Americans have reported PTSD at some point in their lives?
8%
Somatic symptom disorder is observed in what percentage of female first-degree relatives of patients with somatic symptom and related disorders?
10-20%
Somatic symptom disorder - prevalence in females?
0.2-2%
Somatic symptom disorder - prevalence in males?
< 0.2%
What cell type forms the blood-brain barrier and aids neuronal migration during development?
Astrocytes: type of glial cells that are responsible for the development and framework of the neurons. They outnumber neurons 5:1 and contiguously tile the entire CNS.
What three cellular elements of the brain microvasculature compose the blood-brain barrier?
1) endothelial cells
2) astrocyte end-feet
3) pericytes
Aggression in a 5 y/o with autism - only medication approved for this age?
Risperidone
abilify is approved for 6+
What condition is considered high risk for associated hearing defects?
Persistent fetal circulation
When is a PTSD dx considered “with delayed expression”?
when PTSD criteria is not met until at least 6 months after the event
What is the primary reason to decrease psychotropic medication doses in children with liver and kidney disease?
Decreased albumin binding: most psychotropic medications are highly protein bound (with the exception of lithium, methylphenidate, venlafaxine, depakote, gabapentin, and topiramate)
Which medications are NOT highly protein bound? (6)
lithium, methylphenidate, venlafaxine, depakote, gabapentin, and topiramate
hepatic diseases impact drug distribution through what three ways?
1) changes in blood flow
2) protein binding
3) volume of distribution
Uridine glucuronosyltransferase enxymes play a minor role in drug metabolism with the exception of what three medications?
Lamotrigine, morphine, and lorazepam
Why do extended release medications have fewer side effects?
Due to more gradual increases in the plasma concentration
Common side effects of depakote? (5)
1) alopecia
2) rash
3) GI
4) neurological
5) ophthalmological
Absolute contraindications for depakote?
1) hepatic disease
2) known urea cycle disorders
3) pregnancy
4) PCOS in females of child bearing age
Does depakote have FDA approval for mania in adolescents?
No, only approved for seizure disorder
As many as what percent of boys between ages 8-12 may have transient tics?
15%
A 13 y/o F has been dx’d w MDD, single, moderate. TX?
Prozac (8+)
Escitalopram // lexapro (12+)
Which two medications are indicated for OCD in children and adolescents?
Sertraline (6+)
Fluvoxamine (8+)
6F w OCD, tx?
Sertraline (6+)
When she turns 8… Fluvoxamine (8+)
Form of non-associative learning whereby repetitive stimuli elicit weakening behavioral responses if the stimuli do not reinforce or punish the bx
Habituation
Form of non-associative learning whereby repetitive stimuli elicit increasingly powerful responses.
Sensitization