CANMAT depression meds Flashcards
1st line meds for depression
SSRI, SNRI, buproprion, mirtazapine, moclobemide
1st line switch (superiority among 1st line)
sertraline escitalopram mitazapine venlafaxine duloxetine
1st line add on
Li
Olanzapine
Risperidone
Aripiprazole
2nd line antidepressants
clomipramine amitryptiline Other TCAs Selegeline TD patch Trazodone seroquel
2nd line add on
T3
Quetipaine
Buproprion
Mirtazapine
3rd line antidepressants
phenelzine
tranylcypromine
3rd line add on
ziprazidone
buspyrone
modafinil
stimulants
worst sexual SE among antidepressants
sertraline fluoxetine fluvoxamine paroxetine >30%
least sexual SE among antidepressants
buproprion mirtazapine moclobemide selegeline <10%
worst interactions (antidepressants)
fluvoxamine fluoxetine paroxitine sertraline moclobeminde selegeline
least interactions (antidepressants)
citalopram escitalopram venlafaxine desvenlafaxine mirtazapine
1st line antidepressants in pregnant women
SSRIs except paroxetine
1st line antidepressants in nursing mothers
sertraline, paroxetine, citalopram nortryptiline (not fluoxetine)
1st line antidepressants in youth
..and discuss a bit
fluoxetine citalopram Though FDA is prozac and escitalopram other SSRIs except paroxetine 2nd line venlafaxine worse SE and SI Combine with CBT for best results
level 1 evidence for prevention in seasonal ?
wellbutrin