Cancers

Question 1

Myelofibrosis

Answer 1

Increased megakaryocytes
JAK2 mutation
Tear-drop RBC

Question 2

Polycythemia Vera

Answer 2

increased RBCs
JAK2 mutation
Decreased EPO
Ruddy face
Aquagenic pruritus

Question 3

CML

Answer 3

t(9,22) BCR-ABL
Philadelphia chromosome
Imatinib treatment

Question 4

Waldenstrom-Macroglobuinemia

Answer 4

M spike (IgM)
Bleeding
Neurologic defects (sluggish blood)
Seen in LPL

Question 5

LPL

Answer 5

B cells that matured into plasma cells incorrectly
Cause Waldenstrom

Question 6

Diffuse large B-cell

Answer 6

very aggressive
B cells in sheets
Maybe EBV or HHV8

Question 7

Burkitt

Answer 7

EBV
Starry Sky
t(8,14) c-MYC
t(2,8)
t(8,22)

Question 8

Marginal Zone

Answer 8

H pylori infection
t(11,18)

Question 9

Follicular Lymphoma

Answer 9

t(14,18) BCL2
Richter transformation

Question 10

Mantle Cell

Answer 10

t(11,14)
Cyclin D1 overexpressed
Small cells
Poor prognosis
CD5+

Question 11

Mycosis Fungoides

Answer 11

Rash, plaques, nodules
Sezary Syndrome in blood
CD4+

Question 12

Adult T-cell

Answer 12

HTLV-1
Endemic to Japan and Caribbean

Question 13

Hairy Cell

Answer 13

CLL subtype
BRAF mutation
TRAP +

Question 14

CLL

Answer 14

Most common overall
CD5+, CD20+
Smudge cells
Hypogammaglobulinemia (infection cause of death)
Richter transformation to diffuse large B-cell lymphoma

Question 15

APL

Answer 15

AML subtype
t(15,17) blocks maturation by disrupting RAR
Increased DIC risk
Treat with ATRA

Question 16

AML

Answer 16

TdT-
Myeloperoxidase +
Auer rods

Question 17

T-ALL

Answer 17

CD2-,10-,8+

Question 18

B-ALL

Answer 18

t(12,21) favorable
t(9,22) poor
CD2+,10+,19+,20+

Question 19

ALL

Answer 19

TdT+
Myeloperoxidase -
Common in Kids
Down Syndrome Risk Factor

Question 20

Increased megakaryocytes
JAK2 mutation
Tear-drop RBC

Answer 20

Myelofibrosis

Question 21

increased RBCs
JAK2 mutation
Decreased EPO
Ruddy face
Aquagenic pruritus

Answer 21

Polycythemia Vera

Question 22

t(9,22) BCR-ABL
Philadelphia chromosome
Imatinib treatment

Answer 22

CML

Question 23

M spike (IgM)
Bleeding
Neurologic defects (sluggish blood)
Seen in LPL

Answer 23

Waldenstrom-Macroglobuinemia

Question 24

B cells that matured into plasma cells incorrectly
Cause Waldenstrom

Answer 24

LPL

Question 25

very aggressive
B cells in sheets
Maybe EBV or HHV8

Answer 25

Diffuse large B-cell

Question 26

EBV
Starry Sky
t(8,14) c-MYC
t(2,8)
t(8,22)

Answer 26

Burkitt

Question 27

H pylori infection
t(11,18)

Answer 27

Marginal Zone

Question 28

t(14,18) BCL2
Richter transformation

Answer 28

Follicular Lymphoma

Question 29

t(11,14)
Cyclin D1 overexpressed
Small cells
Poor prognosis
CD5+

Answer 29

Mantle Cell

Question 30

Rash, plaques, nodules
Sezary Syndrome in blood
CD4+

Answer 30

Mycosis Fungoides

Question 31

HTLV-1
Endemic to Japan and Caribbean

Answer 31

Adult T-cell

Question 32

CLL subtype
BRAF mutation
TRAP +

Answer 32

Hairy Cell

Question 33

Most common overall
CD5+, CD20+
Smudge cells
Hypogammaglobulinemia (infection cause of death)
Richter transformation to diffuse large B-cell lymphoma

Answer 33

CLL

Question 34

AML subtype
t(15,17) blocks maturation by disrupting RAR
Increased DIC risk
Treat with ATRA

Answer 34

APL

Question 35

TdT-
Myeloperoxidase +
Auer rods

Answer 35

AML

Question 36

CD2-,10-,8+

Answer 36

T-ALL

Question 37

t(12,21) favorable
t(9,22) poor
CD2+,10+,19+,20+

Answer 37

B-ALL

Question 38

TdT+
Myeloperoxidase -
Common in Kids
Down Syndrome Risk Factor

Answer 38

ALL