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IBI Test 3 Cancers > Cancers > Flashcards

Cancers Flashcards

1
Q

Myelofibrosis

A

Increased megakaryocytes
JAK2 mutation
Tear-drop RBC

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2
Q

Polycythemia Vera

A

increased RBCs
JAK2 mutation
Decreased EPO
Ruddy face
Aquagenic pruritus

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3
Q

CML

A

t(9,22) BCR-ABL
Philadelphia chromosome
Imatinib treatment

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4
Q

Waldenstrom-Macroglobuinemia

A

M spike (IgM)
Bleeding
Neurologic defects (sluggish blood)
Seen in LPL

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5
Q

LPL

A

B cells that matured into plasma cells incorrectly
Cause Waldenstrom

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6
Q

Diffuse large B-cell

A

very aggressive
B cells in sheets
Maybe EBV or HHV8

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7
Q

Burkitt

A

EBV
Starry Sky
t(8,14) c-MYC
t(2,8)
t(8,22)

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8
Q

Marginal Zone

A

H pylori infection
t(11,18)

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9
Q

Follicular Lymphoma

A

t(14,18) BCL2
Richter transformation

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10
Q

Mantle Cell

A

t(11,14)
Cyclin D1 overexpressed
Small cells
Poor prognosis
CD5+

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11
Q

Mycosis Fungoides

A

Rash, plaques, nodules
Sezary Syndrome in blood
CD4+

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12
Q

Adult T-cell

A

HTLV-1
Endemic to Japan and Caribbean

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13
Q

Hairy Cell

A

CLL subtype
BRAF mutation
TRAP +

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14
Q

CLL

A

Most common overall
CD5+, CD20+
Smudge cells
Hypogammaglobulinemia (infection cause of death)
Richter transformation to diffuse large B-cell lymphoma

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15
Q

APL

A

AML subtype
t(15,17) blocks maturation by disrupting RAR
Increased DIC risk
Treat with ATRA

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16
Q

AML

A

TdT-
Myeloperoxidase +
Auer rods

17
Q

T-ALL

A

CD2-,10-,8+

18
Q

B-ALL

A

t(12,21) favorable
t(9,22) poor
CD2+,10+,19+,20+

19
Q

ALL

A

TdT+
Myeloperoxidase -
Common in Kids
Down Syndrome Risk Factor

20
Q

Increased megakaryocytes
JAK2 mutation
Tear-drop RBC

A

Myelofibrosis

21
Q

increased RBCs
JAK2 mutation
Decreased EPO
Ruddy face
Aquagenic pruritus

A

Polycythemia Vera

22
Q

t(9,22) BCR-ABL
Philadelphia chromosome
Imatinib treatment

23
Q

M spike (IgM)
Bleeding
Neurologic defects (sluggish blood)
Seen in LPL

A

Waldenstrom-Macroglobuinemia

24
Q

B cells that matured into plasma cells incorrectly
Cause Waldenstrom

25
Q

very aggressive
B cells in sheets
Maybe EBV or HHV8

A

Diffuse large B-cell

26
Q

EBV
Starry Sky
t(8,14) c-MYC
t(2,8)
t(8,22)

27
Q

H pylori infection
t(11,18)

A

Marginal Zone

28
Q

t(14,18) BCL2
Richter transformation

A

Follicular Lymphoma

29
Q

t(11,14)
Cyclin D1 overexpressed
Small cells
Poor prognosis
CD5+

A

Mantle Cell

30
Q

Rash, plaques, nodules
Sezary Syndrome in blood
CD4+

A

Mycosis Fungoides

31
Q

HTLV-1
Endemic to Japan and Caribbean

A

Adult T-cell

32
Q

CLL subtype
BRAF mutation
TRAP +

A

Hairy Cell

33
Q

Most common overall
CD5+, CD20+
Smudge cells
Hypogammaglobulinemia (infection cause of death)
Richter transformation to diffuse large B-cell lymphoma

34
Q

AML subtype
t(15,17) blocks maturation by disrupting RAR
Increased DIC risk
Treat with ATRA

35
Q

TdT-
Myeloperoxidase +
Auer rods

36
Q

CD2-,10-,8+

37
Q

t(12,21) favorable
t(9,22) poor
CD2+,10+,19+,20+

38
Q

TdT+
Myeloperoxidase -
Common in Kids
Down Syndrome Risk Factor

IBI Test 3 Cancers (1 decks)

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