Cancer treatment with Nuclear medicine

Question 1

What is Radioisotope Therapy?

Answer 1

Precision treatment : radioactive drug compound seeks and destroys cancer cells

Question 2

What is used to treat Neuroendocrine tutors ?

Answer 2

lutetium-177 DOTATATE

Question 3

What is used to treat Paraganglioma and Pheochromocytoma?

Answer 3

iodine-131
MIBG

Question 4

What is used to treat Thyroid Cancer?

Answer 4

iodine-131

Question 5

What is used to treat Non-Hodgkin’s Lymphoma

Answer 5

yttrium-90 ibritumomab tiuxetan

Question 6

What is used to treat Neuroblastoma?

Answer 6

iodine-131 MIBG

Question 7

Benefits of Radioisotope Therapy?

***STOL = acronym

Answer 7

1. Highly selective—kills cancer cells and spares healthy cells
2. Can be tailored to the unique biologic characteristics of the patient and the molecular properties of the tumor
   3.Virtually all performed as outpatient procedures
   4.Side effect rates less than other treatments

Question 8

What is used to treat Liver Cancer (Hepatocellular Carcinoma) and Liver-Dominant Metastatic Disease?

Answer 8

selective internal radiation therapy (SIRT)
with yttrium-90 microspheres

Question 9

What is used to treat Bone Metastases from Castration-Resistant Prostate Cancer?

Answer 9

radium-223 dichloride, samarium-153
lexidronam, and strontium-89 chloride

Question 10

I have not included survival rates…but put in order of best to worst depending on type of Cancer

Answer 10

• Thyroid Ca: 90% cure rate
• Non-Hodgkin’s Lymphoma: 75% effective
• Neuroblastoma: 57-75% response rates
• Neuroendocrine tutors: progression-free survival rate: 29 months
• Paraganglioma and Pheochromocytoma: survival 36 months
• Liver Cancer: 17-20 months survival rate
• Bone Metastases from Castration-Resistant Prostate Cancer: between 3.6-month overall
  survival benefit and 5.6-month benefit