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Skin, Blood & Lymph Exam #1 > Cancer Pharmacology 2 > Flashcards

Cancer Pharmacology 2 Flashcards

1
Q

The discovery and use which drug dramatically increased the length of survival in patients with ALL?

What 4 drugs are all active against ALL?

What combination is used to induce remission?

A

MTX

6-mercaptopurine, cyclophosphamide, vincristine and daunorubicin.

Vincristine and prednisone, plus 1 other agent.

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2
Q

What is given as a prophylactic in ALL against CNS leukemia?

A

Intrathecal MTX

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3
Q

What is the most active agent for AML?

What agent is preferred?

How is remission achieved in AML?

A

Cytarabine

Idarubicin

After remission is achieved, chemo is required to maintain remission and to induce cure (Cytarabine).

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4
Q

What is the standard first-line therapy in previously untreated patients with CML?

A

Imatinib

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5
Q

What 2 drugs were initially used for patients with CML who were intolerant to Imatinib, but now is believed to be as suitable of a therapy?

What other drug can be used?

A

Dasatinib and Nilotinib

Busulfan

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6
Q

What are the 2 most widely used alkylating agents used for CLL?

What is meant by COP and CHOP?

A

Chlorambucil (often used w/ prednisone) and cyclophasphamide.

COP: *cyclophosphamide combined with *vincristine and prednisone.
CHOP: *cyclophosphamide combined with *vincristine, prednisone and *doxorubicin.

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7
Q

Bendamustine used with prednisone is approved for what?

A

CLL

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8
Q

What is Fludarabine indicated for?

A

CLL

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9
Q

What is the MOA of Ofatumumab?

What makes it unique?

What is it indicated for?

A

It is a human IgG1 antibody that binds to a different CD20 epitope than Rituximab.

It maintains activity in Rituximab-resistant tumors.

It is approved for CLL that is refractory to Fludarabine.

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10
Q

What chemotherapy regimen is used once the stage I to stage IIA transition has occurred in HL?

A 
ABVD:
Doxorubicin
Bleomycin
Vinablastine
Dacarbazine
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11
Q

What regimens may be used in the advanced stages of HL (stage III and stage IV)? (MOPP, ABVD, Stanford V)

A

MOPP: mechlorethamine, vincristine, procarbazine and prednisone.

ABVD: doxorubicin, bleomycin, vinblastine, and dacarbazine.

Stanford V: doxorubicin, vinblasine, mechlorethamine, vincristine, bleomycine, etoposide and prednisone.

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12
Q

What combination chemotherapy is used in Diffuse Large Cell NHL?

A

CHOP: cyclophosphamide, doxorubicin, vincristine and prednisone (best initial therapy).

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13
Q

What chemotherapy is given in initial pharmacological treatment of Follicular NHL?

A

Bendamustine + rituximab

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14
Q

What is given for Multiple Myeloma?

A

MP protocol: melphalan + prednisone

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15
Q

What regimens are used in Stage II Breast Cancer (node positive disease, 1-3)?

A

CMF: cyclophosphamide, MTX, 5-fluorouracil.

FAC: 5-fluorouracil, doxorubicin, cyclophosphamide.

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16
Q

What 2 drugs are given for hormone-refractory prostate cancer that provides palliation in patients with bone pain and considered the “standard of care”?

What other drug combo is approved?

A

Docetaxel and prednisone - standard if care

Mitoxantrone and prednisone

17
Q

What 3 regimens are used as adjuvant therapy for patiients with CRC in high risk stage II and III?

A

FOLFOX: leucovorin, 5-fluorouracil and oxaliplatin.

XELOX: capecitabine (xeloda) and oxaliplatin.
-used after surgery and reduces recurrence by 35%.

FOLFIRI: leucovorin, 5-fluorouracil and irinotecan.
-Ziv-afilbercept may be added.

18
Q

What 3-drug combo is used as the standard treatment combination for NSCLC? What histology must they have?

A

Bevacizumab plus carboplatin and paclitaxel. They must have non-squamous histology.

19
Q

What combination is given if a patient with NSCLC is not a good candidate for Bevacizumab or has SCC histology? (2/3)

A

(Cisplatin or carboplatin) and cetuximab

20
Q

What drugs can be used in maintenance chemotherapy for NSCLC? (4)

A

Pametrexed
Erlotinib
Afatinib
Osimertinib

21
Q

What drug combination is used in SC NSCLC? (3)

What drug is used in cancers that have progressed on or after platinum-based chemotherapy?

What is used as second-line monotherapy in patients who have failed a platinum-based regimen?

A

Cisplatin, gemcitabine and necitumumab.

Nivolumab

Topotecan

22
Q

What is the 3-drug regimen for testicular cancer?

A

PEB: cisplatin, etoposide and bleomycin

23
Q

What are the 2 most active cytotoxic agents against malignant melanoma?

What 2 drugs are approved for unresectable or metastatic melanoma as monotherapy?

A

Dacarbazine and cisplatin

Nivolumab and pembrolizumab

24
Q

What is the drug class used for brain cancers?

What is used as a single agent?

What is the 3-drug regimen?

What is used alone or in combo and has shown clinical activity against adult GBM?

A

Nitrosureas

Carmustine

PCV: *procarbazine, lomustine and *vincristine

Bevacizumab

25
Q

Drug regimen:

6-mercaptopurine, cyclophosphamide, vincristine and daunorubicin.

Remission achieved via: vincristine and prednisone + 1 of the above.

A

ALL

26
Q

Drug regimen:

*Cytyrabine + Idarubicin

A

AML

27
Q

Drug regimen:

Imatinib
Basatinib + nilotinib
Busulfan

A

CML

28
Q

Drug regimen:

Chlorambucil + prednisone

Cyclophosphamide, vincristine + prednisone (COP)

Cyclophosphamide, doxorubicin, vincristine + prednisone (CHOP)

Bendamustine

Fludarabine

A

CLL

29
Q

Drug regimen:

Doxorubicin, bleomycin, vinblastine + dacarbazine (ABVD)

Doxorubicin, vinblastine, mechlorethamine, vincristine, belomycin, etoposide, + prednisone (Stanford V)

Mechlorethamine, vincristine, procarbazine + prednisone (MOPP)

A

HL stage III and IV (advanced stages)

30
Q

Drug regimen:

Cyclophosphamide, doxorubicin, vincristine + prednisone (CHOP)

R-CHOP

A

DLBCL

31
Q

Drug regimen:

Bendamustine + rituximab

A

Follicular lymphoma

32
Q

Drug regimen:

Melphalan + prednisone

A

MM

33
Q

Drug regimen:

Cyclophosphamide, MTX + 5-FU (CMF)

5-FU, doxorubicin + cyclphosphamide (FAC)

A

Breast cancer stage I -> stage II

34
Q

Drug regimen:

Doxorubicin, bleomycin, vinblastine + dacarbazine (ABVD)

A

HL stage I and stage IIA

35
Q

Drug regimen:

Mitoxantrone + prednisone

Docetaxel + prednisone

A

Prostate cancer

36
Q

Drug regimen:

Bevacizumab, carboplatin + paclitaxel

A

NSCLC (non-squamous)

37
Q

Druge regimen:

Cisplatin, gemcitabine + necitumumab

Nivolumab

A

NSCLC (squamous)

38
Q

Drug regimen:

(Cisplatine + carboplatin) OR (cisplatin + irinotecan)

Platinum therapies

A

SCLC

39
Q

List the major adverse-effect(s) of the following:

Cisplatin
Bleomycin
Doxorubicin
Vincristine/Vinblastine
Cyclophosphamide
A

Cisplatin: otoxicity + nephrotoxicity.

Bleomycin: pulmonary fibrosis.

Doxorubicin: cardiotoxicity.

Vincristine/Vinblastine: peripheral neuropathy.

Cyclophosphamide: hemorrhagic cystitis.

Skin, Blood & Lymph Exam #1 (12 decks)

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