Cancer Oncogenes and tumour suppressor genes Flashcards
1
Q
Examples of oncogenes
A
EGFR, Her-2 SOS ERK Ras c-Myc cyclin D1 Raf
2
Q
Examples of tumour suppressor genes
A
p53 (only one allele needs to be defective so shows oncogenic nature but is TSG as it inhbits proliferation) APC Fas receptor PTEN BRCA1 pRB CIP/KIP family eg p27KIP1
3
Q
Tumour suppressor gene definition
A
Genes involved in