Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology I Exam 3 > Cancer Drugs > Flashcards

Cancer Drugs Flashcards

1
Q

What is the MOA of Cyclophosphamide?

A

Alkylate DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the toxicities of Cyclophosphamide?

A

Forms acrolein –> hemorrhagic cystitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are special considerations of Cyclophosphamide?

A

MESNA/hydration to prevent/treat HC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the MOA of Carmustine?

A

Alkylate DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are special considerations of Carmustine?

A

Crosses BBB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the MOA of Cisplatin?

A

Alkylate DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are toxicities of Cisplatin?

A
  • Renal toxicity

- Acoustic nerve damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are special considerations of Cisplatin

A

Give Amifostine (for renal tox)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the MOA for Doxorubicin?

A

Alkylate DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the toxicities of Doxorubicin?

A

Cardiotoxic due to free radicals produced; toxicity increased by iron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are special considerations for Doxorubicin?

A

Give Dexrazoxane (iron chelator to decrease toxicity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the MOA of Methotrexate?

A

Antimetabolites (S Phase)

Inhibits DHFR
Blocks DNA, RNA, protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are toxicities of Methotrexate?

A
  • Mucositis
  • Thrombocytopenia
  • Nephrotoxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are special considerations of Methotrexate?

A

Leucovorin rescue (bypasses inhibited reductase)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the MOA of 6-Mercaptopurine?

A

Antimetabolites (S Phase)

Converted by HGPRT to a ribonucleotide which inhibits synthesis of purine nucleotides: DNA, RNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are toxicities of 6-Mercaptopurine?

A
  • Bone marrow suppression
  • Jaundice
  • Allopurinol = fatal blood dyscrasias
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are special considerations with 6-Mercaptopurine?

A

Leucovorin rescue

Avoid use with allopurinol or reduce dose

18
Q

What is the MOA for 5-Fluorouracil?

A

Antimetabolites (S Phase)

Inhibits thymidylate synthase (TS) – blocks DNA synthesis

19
Q

What are toxicities of 5-Fluorouracil?

A

Oral, GI ulcerations

20
Q

What are special considerations with 5-Fluorouracil?

A

Leucovorin enhances response

21
Q

What is the MOA for Paclitaxel?

A

Mitosis Inhibitors (M Phase)

Binds beta-tubulin

22
Q

What are toxicities of Paclitaxel?

A
  • Myelosuppression (severe)
  • Anemia
  • Peripheral neuropathy
23
Q

What is the MOA for Vincristine?

A

Mitosis Inhibitors (M Phase)

Bind to tubulin –> cell cycle arrest

24
Q

What are toxicities of Vincristine?

A

Neurotoxicity

25
Q

What is the MOA for Vincblastine?

A

Mitosis Inhibitors (M Phase)

Bind to tubulin –> cell cycle arrest

26
Q

What are the toxicities for Vincblastine?

A

Myelosuppression

27
Q

What is the MOA for Bleomycin?

A

G2-M Phase

Binds directly to DNA

28
Q

What are toxicities of Bleomycin?

A
  • Hypersensitivity

- Pulmonary fibrosis

29
Q

What are special considerations with Bleomycin

A

Has low myelosuppression

30
Q

What is the MOA for Imatinib (Gleevac)?

A

Tyrosine Kinase Inhibitor

Inhibits Bcr-Abl

31
Q

What are toxicities of Imatinib (Gleevac)?

A

Edema

32
Q

What are special considerations with Imatinib (Gleevac)?

A

Leukemias; test for mutation

33
Q

What is the MOA for Cetuximab?

A

Epidermal Growth Factor Inhibitor

Antibody that binds EGF receptor to inhibit tyrosine kinase –> growth inhibition/apoptosis

34
Q

What are toxicities of Cetuximab?

A
  • Acneiform skin rash

- Hypomagnesemia

35
Q

What are special considerations with Cetuximab?

A

Test for EGFR expression and mutations

36
Q

What is the MOA for Erlotinib?

A

Epidermal Growth Factor Inhibitor

Blocks ATP binding to EGF receptor –> growth inhibition/apoptosis

37
Q

What are toxicities for Erlotinib?

A

Rash, diarrhea, anorexia

38
Q

What are special considerations with Erlotinib?

A

Test for EGFR expression and mutations

39
Q

What is the MOA for Bevacizumab?

A

Epidermal Growth Factor Inhibitor

Prevents binding to VEGF receptor –> inhibits angiogenesis –> slows blood supply/tumor growth

40
Q

What are toxicities of Bevacizumab?

A
  • Bleeding

- Thromboembolism

Pharmacology I Exam 3 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions