Cancer drugs

Question 1

Topoisomerase inhibitors

Answer 1

doxorubicin, etoposide (S phase)

Question 2

alkylating agents

Answer 2

damage DNA (S phase)

Question 3

cisplatin

Answer 3

damage DNA (S phase)

Question 4

antimetabolites

Answer 4

5FU, gemcitabine, MTX, hydroxyurea (S phase)

Question 5

PARP inhibitors

Answer 5

S phase

Question 6

tamoxifene

Answer 6

growth inhibitor

Question 7

bicalutimade

Answer 7

growth inhibitor

Question 8

castration

Answer 8

growth inhibitor

Question 9

imatinib

Answer 9

growth inhibitor

Question 10

eriotinib

Answer 10

growth inhibitor

Question 11

vemurafinib

Answer 11

growth inhibitor

Question 12

paclitaxel

Answer 12

antimitotic

create abnormal spindles

Question 13

vinka alkoids

Answer 13

vincristine, vinorelbine, vinblastine
destabilize MT
antimitotics

Question 14

epothilones

Answer 14

ixebepilone

anormal mitosis via destabilization of MT

Question 15

halichondrins

Answer 15

eribulin

anormal mitosis via destabilization of MT

Question 16

CDK inhibitors

Answer 16

palbociclib, ribociclib, abemaciclib

only work in slow growing cancers (breast)

Question 17

selectivity and toxicity of S, M, CDK inhibitors

Answer 17

myelosuppression and mucositis

Question 18

selectivity and toxicity of M only

Answer 18

neuropathy

Question 19

selectivity and toxicity of growth signal inhibitors

Answer 19

toxicity specific to signal

Question 20

cyclin E

Answer 20

CDK2

Question 21

cyclin A

Answer 21

CDK2 and CDK1

Question 22

cyclin D

Answer 22

CDK4/6

Question 23

Cyclin C

Answer 23

CDK3

Question 24

Cyclin B

Answer 24

CDK1

Question 25

inhibitory P on CDK2

Answer 25

prevent from moving past S

Question 26

inhibitory P on CDK1

Answer 26

prevent from moving past G2