Cancer Drugs Flashcards
1
Q
Treatment Regimen for Small Cell Lung Carcinoma
A
- Immediate treatment with classic chemo/radiation
- Etoposide with Cis/carboplatin
- Amfostine and saline diuresis to limit platinum tox.
2
Q
Treatment Regimen for Non-Small Cell Lung Carcinoma
A
- Immediate treatment with surgical resection
- Chemotherapeutic treatment if resection is not fully possible or metastases
- Cisplatin with Paclitaxel/Docetaxel or Irnotecany/topotecan then premetrexed maintenance with Leucorvorin to minimize neurologic symptoms (hand/stocking)
3
Q
carboplatin
A
- DNA intrastrand cross-linker from platinum free radicals
- less incidence of nephro/ototoxicity
- give with amfostine and saline diuresis
4
Q
cisplatin
A
- DNA intrastrand cross-linker from platinum free radicals
- nephro/ototoxicity is a classic
- give with amfostine and saline diuresis
5
Q
cyclcophosphamide
A
- alkylating agent prodrug
- hemorrhagic cystitis and pulmonary fibrosis
- give with Mesna to prevent cystitis
6
Q
docetaxel
A
- microtubule stabilzer
- increased mortality in NSCLC
7
Q
doxorubicin
A
- DNA intercalator/free radical generation/topo II inhibition
8
Q
etoposide
A
- Topo II inhibitor
- hematologic toxicity is dose limiting
9
Q
gemcitabine
A
- DNA polymerase inhibitor through incorporation during DNA synthesis
10
Q
ifosfamide
A
- intra/inter-strand crosslinker
- increase worry of infection due to blood dyscrasia
11
Q
irinotecan
A
- DNA-topo I complex stabilizer (inhibits disassembly)
12
Q
paclitaxel
A
- microtubule stabilization (stops cell division)
- myalgias/arthralgias
13
Q
pemetrexed
A
- DHFR inhibitor (like methotrexate)
- elevated Liver function tests and serum creatine
14
Q
topotecan
A
- DNA-topo I complex stabilizer (inhibits disassembly)
- hyperbilirubinemia
15
Q
vincristine
A
- inhibits microtubule assembly (spiral aggregation)
- spinal injection (intrathecal) is fatal
