Cancer Drugs

Question 1

Antiobiotics

Answer 1

Dactinomycin
Doxorubicin
Daunorubicin
Bleomycin

Question 2

Alkylating Agents

Answer 2

Cyclophosphamide
Ifosfamide
Nitrosoureas
Busulfan

Question 3

Microtubule Inhibitors

Answer 3

Vincristine
Vinblastine
Paclitaxel

Question 4

Inhibits dihydrofolate reductase

Answer 4

Methotrexate

Question 5

Inhibits thymidylate synthase

Answer 5

5-FU

Question 6

Inhibits DNA polymerase

Answer 6

Cytarabine

Question 7

Metabolized by Xanthine Oxidase

Answer 7

6-MP

Azathioprine

Question 8

Generates free radicals

Answer 8

Doxo/Dauno

Bleomycin

Question 9

Covalent X-links at DNA guanine N-7

Answer 9

Cyclophosphamide

Ifosfamide

Question 10

Requires bioactivation by liver

Answer 10

Cyclophosphamide
Ifosfamide
Nitrosoureas

Question 11

Binds Beta-tubulin

Answer 11

Vincristine

Vinblastine

Question 12

Inhibits microtubule polymerization

Answer 12

Vincristine

Vinblastine

Question 13

Hyperstabilizes microtubules

Answer 13

Paclitaxel (all -taxel/-taxol drugs)

Question 14

Inhibits topoisomerase II

Answer 14

Etoposide

Teniposide

Question 15

Inhibits topoisomerase I

Answer 15

Irinotecan

Topotecan

Question 16

Inhibits ribonucleotide reductase

Answer 16

Hydroxyurea

Question 17

Monoclonal Ab against HER-2

Answer 17

Trastuzumab (Herceptin)

Question 18

Inhibits bcr-abl and c-kit tyrosine kinases

Answer 18

Imatinib

Question 19

Monoclonal Ab against CD-20

Answer 19

Rituximab

Question 20

Inhibits B-Raf kinase V600E

Answer 20

Vemurafenib

VE-MU-RAF-enib
V➡️E…
MU-tation…
on RAF

Question 21

Monoclonal Ab against VEGF

Answer 21

Bevacizumab

Question 22

Antimetabolites

Answer 22

Methotrexate
5-FU
Cytarabine
Azathioprine
6-MP
6-TG

Question 23

Decreased dTMP synthesis

Answer 23

Methotrexate

5-FU

Question 24

Decreases purine synthesis

Answer 24

Azathioprine
6-MP
6-TP

Question 25

Activated by HGPRT

Answer 25

Azathioprine 6-MP 6-TP

Question 26

Covalently complexes folic acid

Answer 26

5-FU

Question 27

Pyrimidine analog

Answer 27

5-FU | Cytarabine

Question 28

Purine analog

Answer 28

Azathioprine 6-MP 6-TP Cladribine

Question 29

Myelosuppression reversible with leucovorin

Answer 29

Methotrexate

Question 30

Myelosuppression NOT reversible with leucovorin

Answer 30

5-FU

Question 31

Overdose rescue with Uridine or Thymidine

Answer 31

5-FU

Question 32

SE of photosensitivity

Answer 32

5-FU

Question 33

Cardiotoxic

Answer 33

Doxo/Dauno | Trastuzumab

Question 34

Treats childhood tumors (Wilms, Ewing, Rhabdomyosarcoma)

Answer 34

Dactinomycin

Question 35

SE of pulmonary fibrosis

Answer 35

Bleomycin | Busulfan

Question 36

SE of hemorrhagic cystitis

Answer 36

Cyclophosphamide | Ifosfamide

Question 37

Crosses blood brain barrier

Answer 37

Nitrosoureas

Question 38

Can be used for CML

Answer 38

Imatinib Busulfan Hydroxyurea

Question 39

Used for sickle cell

Answer 39

Hydruxyurea

Question 40

Increased risk of endometrial cancer

Answer 40

Tamoxifen

Question 41

Increased risk of Progressive Multifocal Leukoencephalopathy (PML)

Answer 41

Rituximab

Question 42

SE of impaired wound healing

Answer 42

Bevacizumab

Question 43

EGFR tyrosine kinase inhibitor

Answer 43

Erlotinib

Question 44

Cisplatin/Carboplatin nephrotoxicity prevention

Answer 44

Amifostine or Chloride diuresis