Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Heme and Lymph > Cancer Chemotherapy and Ant-Neoplastic Drugs > Flashcards

Cancer Chemotherapy and Ant-Neoplastic Drugs Flashcards

1
Q

What are the 4 Pyrimidine anti-metabolite drugs that inhibit DNA synthesis?

A
  1. 5-fluorouracil
  2. Capecitabine
  3. Cytarabine (Ara-C)
  4. Gemcitabine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is adjust chemotherapy?

A

Drug given after tumor has been removed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is Neoadjuvant chemotherapy?

A

Drug given prior to surgery to remove a tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the MOA of 5-fluorouracil?

A

FdUMP inhibits thymidylate synthase.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is unique about Capecitabine?

A

Prodrug of 5FU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the MOA of Gemcitabine?

A

Kinases convert gemcitabine to nucleotide analogs-> inhibit DNA synthesis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the MOA of Cytarabine (Ara C)?

A

Kinases convert Ara-C to AraCTP-> inhibits DNA synthesis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some therapeutic uses for 5FU?

A

Solid tumors: colorectal and other GI; breast, ovarian carcinomas.

Topical use: basal cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are some therapeutic uses for 5FU?

A

Colorectal cancer; metastatic breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are some therapeutic uses for Gemcitabine?

A

Pancreatic cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are some therapeutic uses for Cytarabine?

A

Acute Myelogenous leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the toxicity associated with use of 5FU?

A

Severe GI intolerance, mucositis, myelosuppression.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the toxicity associated with use of Capecitabine?

A

GI intolerance, mucositis, myelosuppression, hand and foot syndrome.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the toxicity associated with use of Gemcitabine?

A

Myelosuppression-neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the toxicity associated with use of Cytarabine (Ara C)?

A

Severe myelosuppression- granulocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Where is the cell cycle does 5FU exert its effects?

A

S phase

17
Q

What two medications are given with 5FU to enhance its anticancer activity?

A

Methotrexate and Leucovorin

18
Q

Where is 5FU cleared and what enzyme does this?

A

Mainly in the liver by Dihydropyrimidine dehydrogenase (DPD).

19
Q

Where is Capecitabine activated in the body?

A

Activated by the liver via carboxyesterase and Cytidine deaminase, delivered to the tumor, and then converted into 5FU by T/U phosphorylase.

20
Q

What is a use for Capecitabine?

A

Advanced breast cancer

21
Q

What is the MOA for resistance with Ara C?

A

Liver and spleen contain cytidine deaminase (CDA) that has the ability to inactive Ara-C to Ara-U.

22
Q

Besides chain termination, what else does Gemcitabine inhibit?

A

inhibits ribonucleotide reductase thus depleting cellular dNTPs.

Heme and Lymph (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions