Cancer chemo Flashcards
Toxic effects of chemo
BM suppression (anaemia, infection prone, impaired healing)
hair loss
damage to GI epi
sterility
Classes of chemo
Alkylating agents Anti-metabolites Cytotoxic antibodies Microtubule inhibitors Steroid hormones/ antagonists
alkylating agent mechanism
Binds with DNA and interferes with transcription and replication
Example of alkylating agent
cyclophosphamide
melphalan
antimetabolites mechanism
interferes with nucleotide/DNA synthesis e.g. purine, pyramidine
examples of antimetabolites
methotrexate
fluoro-uracil
mecaptopurine
cytotoxic ab mechanism
intercalates into DNA and impairs synthesis and function
examples of cytotoxic ab
dactinomycin
doxorubicin
example of microtubule inhibitor
vincristine
microtubule inhibitor mechanism
blocks tubulin polymerisation and normal spindle formation
Steroid antagonist examples
Tamoxifen
Bicalutamide