Cancer chemo Flashcards

1
Q

Toxic effects of chemo

A

BM suppression (anaemia, infection prone, impaired healing)
hair loss
damage to GI epi
sterility

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2
Q

Classes of chemo

A
Alkylating agents
Anti-metabolites
Cytotoxic antibodies
Microtubule inhibitors
Steroid hormones/ antagonists
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3
Q

alkylating agent mechanism

A

Binds with DNA and interferes with transcription and replication

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4
Q

Example of alkylating agent

A

cyclophosphamide

melphalan

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5
Q

antimetabolites mechanism

A

interferes with nucleotide/DNA synthesis e.g. purine, pyramidine

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6
Q

examples of antimetabolites

A

methotrexate
fluoro-uracil
mecaptopurine

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7
Q

cytotoxic ab mechanism

A

intercalates into DNA and impairs synthesis and function

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8
Q

examples of cytotoxic ab

A

dactinomycin

doxorubicin

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9
Q

example of microtubule inhibitor

A

vincristine

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10
Q

microtubule inhibitor mechanism

A

blocks tubulin polymerisation and normal spindle formation

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11
Q

Steroid antagonist examples

A

Tamoxifen

Bicalutamide

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