Cancer Biologics

Question 1

ATRA

Answer 1

• for PML helps to differentiate cells

Tox: leukocytosis (N), capillary leak syndrome (pulmonary edema, respiratory failure, renal failure)

Question 2

Lenolidomide

Answer 2

unclear anti-inflammatory for MM

Question 3

Imatinib

Answer 3

tyrosine kinase inhibitor, binds cleft of ABL for CML tx; also for cKit inhibition in GIST
Tox: edema, rash, pancytopenia, GI
Resistance: cleft can mutate to escape

Question 4

Erlotinib

Answer 4

TKI in EGFR mutant NSCLC (women, non-smoker, with broncheoalveolar histology)
Tox: RASH, GI, Pulm

Question 5

Crizotinib

Answer 5

• inhibits activin receptor-like kinase (ALK), ROS1 for NSCLC with EML4-ALK1 with kinase activity always, younger, non-smoker

Question 6

Vemurafenib

Answer 6

RAF Inhibitor, targets V600E BRAF

Tox: Skin cancers (cutaneous squamous cell and keratocanthomas)

Question 7

Bortezomib

Answer 7

Proteosome inhibitor for MM

Tox: neuropathy, myelosupression

Question 8

Rituximab

Answer 8

anti B-cell CD20 for B cell NHLs

Tox: HA, flushing, chills, fever, GI

Question 9

Cetuximab

Answer 9

MAB to EGFR, radiation sensitizer, K-RAS and BRAF WON’T RESPOND)

Question 10

Bevsacizumab

Answer 10

VEGF inhibitor
Tox: pulmonary hemorrhage in pt with squamous cell ca.
Tox: HTN, pulm hemorrhage, proteinuria

Question 11

Trastuzumab

Answer 11

blocks HER2 signalling, and cell mediated immunity

Tox: cardiac