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RWJ Heme Onc Renal > Cancer Biologic Drugs > Flashcards

Cancer Biologic Drugs Flashcards

(46 cards)

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1
Q

Aside from Hypersensitivity and Increased LFTs, Name 2 Adverse effects of Cetuximab

A
  1. Acneiform Eruption (red paps in sebaceous areas)
  2. Hypomagnesia
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2
Q

Considering that B-RAF mutations commonly result in Melanoma, it makes sense to use a Vengeful drug such as _______.

A

Vemurafenib

“V for Vemura” (V for vendetta)

“Wrathful Vengenace= RAF-ful Vengange”

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3
Q

Key MOA Difference of 1. Nivolumab and 2. Atezolizumab

A
  1. Nivo targets T-cells’ PD-L1
  2. Atezo targets Tumors’ PDL-1
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4
Q

Name the two main PD-1 Binding Drugs

A
  1. Nivolumab
  2. Atezolizumab
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5
Q

Ironically, the Vengeful Vemurafenib’s main adverse effect is

A

OTHER SKIN CANCERS

(cutaneous squam or keratocanthomas)

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6
Q

Two main drugs to treat NSCLC. One is against EGF-R, the other inhibits ALK.

A
  1. Erlotinib
  2. Crizotinib
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7
Q

Crizotinib is used for NSCLC, but ONLY if there a mutation in ______ or ______, which makes sense because it inhibits both of these guys.

A
  • ALK
  • ROS 1
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8
Q

Rituximab 3 indications

A
  1. CLL
  2. Diffuse B-Cell Lymphoma
  3. Follicular Lymphoma
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9
Q

ATRA binds mutated Retinoic acid receptor to drive differentation of ____ cells

A

Promyelocytic

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10
Q

Rituximab MOA

A
  • Target CD20 on B cells
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11
Q

B-RAF is an ____ with activating mutations seen in melanoma and other cancers

A

Oncogene

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12
Q

Imatinib Reks Gastrointestinal Stromal Turmors (GIST) by binding ______.

A

C-Kit

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13
Q

ATRA stands for __________ and is used to teat Acute Promyelocytic Leukemia (APmL)

A

All-Trans Retinoic Acid “The APL contains Retinoic acid”

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14
Q

Main Tyrosine Kinase Inhibitor drug that treats CML and GIST?

A

Imatinib

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15
Q

Cetuixmab treat which 2 main thirsty cancers?

A
  • Colorectal
  • Head & Neck
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16
Q

If you take imatinib, you should avoid grapefruit, but CYP_____ metabolizes it

A

3A4

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17
Q

” V for Vemurafenib” treats Melanoma by inhibiting mutated _____,, specifically the V600E mutation

A

BRAF

“Wrathful Vengence”

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18
Q

Trastuzumab binds to _______ tyrosine kinase and prompts immune-mediated antibody-dependent cellular cytotoxicity.

“Trash-Tuzumab”

A

HER-2

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19
Q

You might think you’re in love with Trastuzumab, but it might be the ______ that occurs as its main side-effect

Study These Flashcards
A

Cardiomyopathy

20
Q

Tumors can bind on ________ Receptors on T-Cells to shut them down.

21
Q

What teratogenic drug treats both Multiple Myeloma and Non-Hodg Lymphoma?

22
Q

Imatinib smacks CML and by binding to the cataylitc cleft of _____ on the ______ Chimeric Fusion. This is great, because you don’t want it to be constituitvely active anymore.

23
Q

Lenalidomide treats both _____ and _____

24
Q

Blake Bortezomib 2 Adverse Side Effects

Study These Flashcards
A
  1. Neuropathy ( QB stocking Glove)
  2. Myelosuppresion (WBC, RBC, Platelet)
25
Nivolumab and Atezolizumab MOA to treat cancer
Block the T-cell Sleeper, PDL1
26
Aside found wound healing probs, GI perforation, and Proteinuria, what 3 Adverse effects do you expect with Bloody Bevacizumab
* Cardiac (HTN) * Arterial Thrombotic Events (TIA, Stroke, Etc.) * Pulm Hemorrhage
27
Cetuximab and Erlotinib both target \_\_\_\_\_\_, but treat different diseases
EGF-R
28
Aside from Lenalidomide, ______ is a proteosome inhibitor that can also tackle Multiple Myeloma as fast as a ***Jaguar***.
**Bortezomib** "Blake Bortles"
29
***Ready, \_\_\_\_\_\_*** Goes the extra mile to tag Extracellular Epidermal Growth Factor's Receptor (EGF-R) while drinking a glass of \_\_\_\_\_\_, which also targets (EGF-R). ## Footnote **[Name the 2 Drugs that target EGF-R]**
- Cetuximab "Ready, SET-uximab Go" - Erlotinib "Merlot-inib"
30
Lenalidomide is thought to treat both MM & NHL by inhibiting the two immuno-products known as ______ and \_\_\_\_\_\_
* TNF-Alpha * IL-10
31
Main anti B-cell CD20 targeting drug is called \_\_\_\_\_\_\_
Rituximab
32
Aside from Fatigue, rashes, and MSK probs, name 3 key adverse effects of the PDL-1 (tumor) inhibitor Atezolizumab
1. Pneumonitis 2. Colitis 3. Hepatitis
33
In regards to Nivolumab vs Atezolizumab, Atezo can only treat _____ carcinoma, whereas Nivo treats that and Hodgkin, Melanoma, NSCLC, Renal, and Head/Neck
Urothelial
34
Aside from nausea, vomiting, diahrrhea, cough, and shortness of breath, what key Adverse Reaction will the EGF-R blocker Erlotinib have?
**Aceniform Eruption**
35
To tackle solid tumors, the drug ______ is Anti-VEGF
Bevacizumab
36
Key adverse effect of Lenalidomide?
Teratogenic!
37
Long Mnemnoic for Crizotinib?
Crazy Alkaline Rose Tea "Crizo, ALK, ROS-1"
38
Bloody Bevacizumab's MOA to treat Lung, Colon, and breast cancer
Anti-VEGF Receptor
39
Blake Bortezomib inhibits that vicious Jaguar bite from ______ \_\_\_\_\_ to down-regulate over-active NFKB signaling.
26-S Proteasome
40
Aside from avoiding Grapefruit because of CYP3A4, Name 3 Adverse Effects of **Imatinib** that you should worry about when treating Chronic Myeloid Leukemia (CML),
* Edema (face hands feet) * Skin Rash * Pancytopenia
41
Just like Cetuximab, _______ also tags against EGFR-R, and also causes that Acneiform Eruption.
**Erlotinib** "Glass of Erlot-tinib"
42
ATRA is used to treat ____ \_\_\_\_ \_\_\_\_
Acute Promyelocytic Leukemia
43
2 Mutations that decrease Cetuximab's Response
1. K-RAS 2. BRAF
44
Main drug used to bind HER-2? (I swear it's not ***Garbage,*** it's actually pretty good against Breast cancer and GI Cancer.)
Trastuzumab "Trash-Tuzumab"
45
3 Adverse effects from **ATRA** when treating acute promyelocytic leuk? (Note: This can be reversed via Steroids and Chemo)
* Leukocytosis (especially neutros) * Capillary Leak Syndrome (pulm edema) * Renal Failure
46
What's the ***Craziest*** Inhibitor of (ALK) Activin Receptor=lke Kinase/ other tyrosine kinase that treats NSCLC?
**Crizotinib** "Crazy-tinib"

RWJ Heme Onc Renal (2 decks)

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