Cancer Flashcards
How is cancer defined/characterized
Abnormal cells that divide without control over division. DNA of cells becoming damaged leading to abnormal gene function
What are the differences in structure between a normal cell and a cancer cell?
Normal: large cytoplasm, single nucleus with smooth border, single nucleolus, fine chromatin
Cancer: small cytoplasm, multiple nuclei with irregular border, multiple large nucleolus, coarse chromatin
True or false hyperplasia of cells is abnormal tissue
False. Hyperplasia is still an abnormality in the transition to invasive cancer, but at this point it is still normal tissue, just an increase in the number of normal cells
Describe the 5 steps from a normal cell to invasive cancer
normal cell –> cell mutation –>hyperplasia (normal tissue) –> dysplasia –> cancer in situ (more abnormal than normal cells) –> invasive cancer
Describe dylpasia
Abnormal changes in cellular shape, size or organization. There is a replacement of a mature cell type with a less mature cell type.
True or false, in situ tumors do not invade the basement membrane
true
True or false, benign tumors continue to grow in size abnormally
true, however they will not invade other unrelated tissues or organs in the body
Describe a malignant tumor
Cells that invade the basement membrane and invade other parts of the body
Name two ways malignancy occurs
Direct extension: neighboring organs, tissues
Indirect extension: to distant sites via the vascular, lymphatic system or seeding of CA cells into body cavities
Carcinoma arises from what tissue?
Skin or tissues that line or cover internal organs
How are cancer categorized?
The tissue which they arise
Sarcoma arises from
supportive and CT: bone, cartilage, fat, muscle, blood vessels
Which is more malignant carcinoma or sarcoma?
Sarcoma
Where does leukemia arise from
blood forming tissue/bone marrow
Where does lymphoma and myeloma arise from
cells of the immune system
Where does CNS cancer arise from
brain and SC
Most breast cancers are categorized as what kind?
Carcinoma
how many CA survivors are there in the US
15.5 million
Talk about the overall estimated trends in cancer prevalence and survivor rate
CA survivors is going to increase, however more people are going to be diagnosed with CA
What is the most prevalent CA among men? women?
Prostate
Breast
What is a major risk factor for CA?
AGE: the older you are the more at risk
What is the lifetime probability of having cancer in your lifetime for males? females?
Males: 1 in 2
Females: 1 in 3
Where age is 89% of CA prevalence located?
50+
True or false, more people are surviving their CA diagnosis as time goes on
true
What are african american women more likely to be diagnosed with?
triple negative breast cancer, they are not positive on three hormone receptors making it much more difficult to breast
True or false, african americans have lower survival rates than whites for most cancer types
true: later stage diagnosis, lower likelihood of receiving quality treatment, triple negative breast cancer
What cancer is the leading cause of death in men an women?
lung and bronchus CA
What mechanism does radiation work through vs. chemotherapy?
Radiaiton: direct damage to DNA (CA cells are more fragile than healthy ones so they will die more easily)
Chemotherapy: targets an aspect of cell growth cycle
Name the phases of the proliferative cycle
GI: postmiotic period - protein synthesis and cell growth
Synthesis: DNA replication
G2: premiotic: cell checks DNA and gets ready to divide
Mitosis: cell division
Chemo agents target what?
Either one phase of cell growth (postmitotic, synthesis, premitotic, mitosis) or all phases
Define neoadjuvant chemotherapy
before surgery: shrinks the CA to allow it to be removed
Define adjuvant chemotherapy
after surgery: used to kill undetected cells that have traveled from the tumor
Metastatic disease
goal is to keep CA at bay
Name the neurotoxic chemotherapy agents
- Taxanes: commonly used with breast cancer
- Alkaloids
- Platinum based
- epothilones
- PI
- Thalidomine and lenalidomide
- Eribulin
- Nelarabine
Chemotherapy targets what kind of cells
rapidly dividing ones
What is alopecia
hair loss
What is the premise of targeted therapy
specifically attach to different receptors on CA hormones
How do targeted therapies differ from standard chemo?
Targeted act on specific molecular targets where chemo acts on all rapidly dividing cells
Targeted are cytostatic (block proliferation) and chemo is cytotoxic (kill cells)
What kind of therapy is SERM and Aromatase inhibitor? and what are they generally used for?
Hormone therapy commonly used for breast cancer
What kind of therapy is HER2 and herceptin and what CA is it gernally used for?
Monoclonal antibodies used for breast cancer
Autologous, syngeneic, allogenic transplants generally used for what kind of CA?
Blood/liquid
Define: autologous, syngeneic, allogenic in terms of transplants
Autologous: your own stem cells have been removed and used
Syngeneic: identical twin
Allogenic: someone who is a relatively close match to you
What is BMT and PBSCT?
And why are they used in cancer treatment?
What types of CA are treated with it?
BMT: bone marrow translplant
PBSCT: peripheral blood stem cell transplantation
Used in CA treatment bc with high dose chemo and/or radiation can destroy pts bone marrow. They can no longer make WBC, WBC, platelets. This allows them to
Commonly used in liquid CA’s (leukemia, lymphoma, multiple myeloma, neuroblastoma)
How are stem cell transplantations received? and how long does an individual stay in the hospital for?
IV then you wait for engraftment (in hospital for 100 days)
What is GVHD
graft vs. host disease: long term complication of transplants
Name some less common treatments of CS
vaccines, cyrosurgery, hyperthermia, lasers, photodynamic
Name the 3 decreasing CA diagnosis
3 increasing?
Decreasing: Colorectal, prostate, lung
Increasing: thyroid, melanoma, liver
50% of CA death due to which four diagnoses
Lung, prostate, breast, colorectum
BRCA 1 and 2 are what?
tumor suppressor genes, therefore when they have a mutation cells go crazy
Change in CA population in head and heck cancers
Then and now
Whats the difference?
Then: 50+ males, alcohol and tobacco use
Now: 30+ females or males, no h/o ATOH or smoking
Difference = HPV!
Breast CA screening recommendations
40?
45-54?
>55?
Known BRCA mutation, 1st degree relative, 25% lifetime risk of breast cancer start at when
40: start annual exams if hx of breast CA
45 - 54: annual screens for all
> 55: biennial screening and should continue as they have a life expectancy >10 yrs
High risk: Start at 30 yrs
What makes you high risk for breast cancer?
- known or likely BRCA mutation and other gentic syndroms
- treated with chest wall radiation for Hodgkin disease
Down the line radiation used to treat Hodgkins lymphoma led to what?
Breast CA
When should an individual be referred to a genetic counselor (concerning breast CA)
family hx of multiple relatives w/breast or ovarian CA, or if relative was diagnosed <50 yrs old
What are the five red flag signs for CA?
1) unexplained weight loos >10 lbs
2) fever, chills, night sweats
3) rest/night pain
4) Fatigue
5) skin changes
ABCDE’s of melanoma
A: assymetry B: border C: color D: dimeter (pencil eraser) E: enlargement or evolving
Signs and symptoms of CA
CAUTION
C: change in bowel and bladder A: A sore that is not healing U: unusal bleeding or discahrge T: thickening or lump I: indigestion or trouble swallowing O: obvious change in wart/mole N: nagging cough or hoarseness
CA staged as In situ:
In situ: abnormal cells are present only in the layer of cell in which they developed
CA staged as regional
CA has spread beyond primary site to nearby lymph, tissues or organs
CA staged as localized
CA is limited to organ which it began without evidence of spread
CA staged as unknown
not enough to determine stage
CA staged as distant/metistatic
CA has spread to distant tissue, lymph or organs
Explain the T of cancer staging
T: size or extent of tumor
Tis: in situ T1: <20mm T2: 50<20 mm T3: >50 mm T4: any size with direct extension to the chest wall and or to the skin
Explain the N of cancer staging
N: amount spread to lymph nodes
pN0: no regional lymph node metastasis
pN1: 1-3 axillary lymph nodes
pN2: 4-9 nodes
pN3: > or = 10 nodes
Explain the M of cancer staging
M: metastasis
0: non
1: metastasis
Stage IV CA means what
CA has spread to distant tissue or organs
Stage 0 CA means what
In situ: not within the membrane
Tests used for stagin
Physical exam, imaging, lab tests, pathology reports, surgical reports
What were the most common functional cited problems in CA patients in the cited study
Balance and ambulation
True or false oncology clinicians adequately document functional problems in CA patients
False!
True or false oncology is a specialization by the ABPTS?
True
In what stage (pre-screening, screening, treatment etc) is rehab appropriate?
Most appropriate?
Always appropriate but particularly pre-treatment
Does a PT’s role in CA care include diagnose?
According to her slide yes
What does the following describe?
Brief investigation of:
Anatomical & physiological status of body systems
Communication ability, affect, cognition, learning style
Review of “red flags” and other screening data
A systems review
What is an orange flag?
Psychiatric symptoms
What is a yellow flag?
Beliefs and judgments