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bmsc > cancer > Flashcards

cancer Flashcards

1
Q

pd-1 inhibitor

A

nivolimab

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2
Q

vemurafinib co prescribe with…

A

ipilimumab

CTLA-4 inhibitor- downregulation of the immune system

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3
Q

GSTM1 gene deletion

A

glutathione- s- transferase m1

50% cuacasians

unable to detoxify wiht phase 2

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4
Q

risk alleles metabolism

A

GSTM1*2

CYP246*4

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5
Q

activatio of p53

A

MAPK- cellular damage

ATM/ATR- DNA damage

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6
Q

reversal of p53 ubiquitination

A

USP7

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7
Q

CDK inhibitor proteins

A

specifific INK4A

non precific- CIP/KIP family- p21, p27, p57

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bmsc (5 decks)

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