Caldwell Handout Objectives

Question 1

2 drugs initially used for acute sinusitis

Answer 1

1. amoxicillin: s. pneumo

2. TMP-SMX: H. flu, M. catarrhalis

Question 2

5 single or combo agents effective against chronic sinusitis

Answer 2

1. clindamycin
2. cefazolin/metronidazole
3. cefuroxime/metronidazole
4. clarithromycin
5. fluoroqinolones

Question 3

one oral and one IM abx used vs. strep pharyngitis; what population would be most likely for this infection

Answer 3

• penicillin G Benzathine (IM)
• penicillin V (oral - thanks O’Neal)
• predominant infection in school-aged children

Question 4

3 single or combo abx agents for COPD

Answer 4

1. TMP-SMX
2. doxycycline
3. azithromycin/clarithromycin

Question 5

3 agents used for pneumonia caused by penicillin-resistant strep pneumo

Answer 5

1. doxycycline
2. clindamycin
3. levofloxacin
   * *rarely need vanco for very highly pen-resistant strep pneumo

Question 6

2 abx for pneumonia caused by legionella

Answer 6

1. fluoroquinolone

2. azithromycin

Question 7

4 abx used vs. CAP in pts >60yo

Answer 7

- 2nd generation cephalosporins:
loracarbef (carbacephem class, beta-lactam) cefuroxime axetil
- 3rd generation cephalosporins:
cefpodoxime
ceftriaxone

Question 8

3 abx used vs. HAP caused by MRSA

Answer 8

• linezolid
• vancomycin
• tigecycline
• *can’t use daptomycin even though it covers MRSA b/c it’s inactivated by surfactant