calcineurin inhibitors (Cs, Tacrolimus) not finished

Question 1

MOA

Answer 1

inhibitors production and release of lymphokines, thereby suppressing cell-mediated immune response

Question 2

important safety info re prescribing and dispensing

Answer 2

must be prescribed and dispensed by brand name
pt need to be stabilised on one brand because switching between formulations without close monitoring may lead to clinically important changes in blood-ciclosporin conc

Question 3

Why do pt need to be maintained on a particular brand

Answer 3

switching between formulations without close monitoring may lead to clinically important changes in blood-ciclosporin concentration

Question 4

is it used for malignancy

Answer 4

no, contraindicated in malignancy with systemic use (in non transplant indications)

Question 5

3 CI

Answer 5

Malignancy (in non-transplant indications); uncontrolled hypertension (in non-transplant indications); uncontrolled infections (in non-transplant indications)

Question 6

Can patient who has uncontrolled hypertension be put on ciclosporin

Answer 6

No, contraindicated in non transplant indications

Question 7

Food & drink interactions - 2x juices

Answer 7

POMELO juice predicted to INCREASE exposure to ciclosporin

PURPLE GRAPE juice predicted to DECREASE ciclosporin exposure

Question 8

Effect of pomelo juice

Answer 8

predicted to increase ciclosporin exposure

Question 9

Effect of purple grape juice

Answer 9

predicted to decrease ciclosporin exposure