CA Bates Flashcards
how many quadrants is the breast broken up into for documentatio
4 horizanl vertical line crossing the nipple
and a 5th area (axillary tail of breast tissue sometimes called tail of spense) and it extends laterally across the anterior axillary fold
how are findings locaalized
as the time on the face of a clock
and
distance in cm from nipple
what are the three most common kinds of breast masses
fibroadenoma (benign tumor)
cysts
breast cancer
commonly palpable as nodular, rope-like densities in women ages 25-50. may be tender or painful. considered benign and are not viewed as a risk factor for breast cancer
” nodular and ropelike”
fibrocystic changes
fibroadenoma age number shape consistency delimitation mobility tenderness retraction signs
age : 15-25
usually puberty and young adults, but up to age 55
number: usually single, may be multiple
shape: round disclike or lobular
consistency: may be soft usually firm
delimitation: well delineated
mobility: very mobile
tenderness: non tender
retraction signs: absent
“smooth, rubbery, round mobile, nontender”
Cysts age number shape consistency delimitation mobility tenderness retraction signs
age : 30-50, regress after menopause except with estrogen therapy
number: single or multi
shape: round
consistency: soft to firm, elastic
delimitation: well delineated
mobility: mobile
tenderness: tender
retraction signs: absent
“soft to firm, round, mobile, tender”
cancer age number shape consistency delimitation mobility tenderness retraction signs
age : 30-90 most common OVER 50
number: single but can coexist with other nodules
shape: irregular or stellate
consistency: firm or hard
delimitation: no clearly delineated from surrounding tissue
mobility: fixed to skin or underlying tissue
tenderness: non tender
retraction signs: maybe
“irregular firm may be mobile or fixed to surrounding tissue
breast masses should be carefully evaluated and usually warrants further investigation like….. (4)
ultrasound, aspiration, mammo, or biopsy
what are three retraction signs
- abnormal contours
- skin dimpling
- nipple retraction and deviation
as breast CA advances it causes fibrosis (scar tissue). shortening of the tissue produces dimpling, changes in contour and retraction of deviation of the nipple. other causes of ____________ are fat necrosis and mammary duct ectasia…. what am i referring to?
retraction signs
variation in the normal convexity of each breast, and compare one side to the other. special positioning may again be useful. marked flattening of the lower outer quadrant of the left breast is an example of what you may see in this type of retraction sign
abnormal contours
seen when pts arms are at rest, during special positioning and on moving or compressing the breast
skin dimpling
nipple is flattened or pulled inward. can be broadened and feels thickened. when involvement is radially asymmetric the nipple may point in a different direction from its normal counterpart, typically toward the underlying cancer
nipple retraction and deviation
produced by lymphatic blockade. appears as thickened skin with enlarged pores
also called peau d’orange (orange peel) sign
seen first in the lower portion of the breast or areola
edema of the skin
uncommon form of breast cancer usually starts as a scaly eczema like lesions that may weep, crust, or erode.
breast mass may be present.
suspect this is any persisting dermatitis of the nipple and areola occur.
can present with invasive breast cancer or ductal carcinoma in situ
Paget’s Disease of the Nipple
inappropriate discharge of milk containing fluid, and is abnormal if it occurs 6 or more months after childbirth or cessation of breast feeding
galactorrhea
milky discharge unrelated to prior pregnancy and lactation. causes include hypothyroidism, pituitary prolactinoma, and drugs that are dopamine agonists, including many psychotropic agents and phenothiazines
nonpuerperal glactorrhea
spontaneous unilateral bloody discharge fro one or two ducts warrants further evaluation for ____________
intraductal papiloma
ductal carcinoma in situ or Pagets disease of the breast
clear serous, green, black, non bloody discharge that are multiductal are
usually benign
masses nodularity and change in color or inflammation especially in the incision line suggest
recurrence of breast cancer
deeply pigmented velvety axillary skin suggests
acanthosis nigricans
associated with internal malignancy
thickening of the nipple and loss of elasticity suggests
underlying cancer
tender cords
benign but sometimes painful conditon of dilated ducts with surrounding inflammation, sometimes associated masses
mammary duct ectasia
hard irregular poorly circumscribed nodules fixed to the skin or underlying tissue
cancer
if you are above the age of _____ it is cancer until proven otherwise
50
what is the most common type of cancer in women worldwide
and the second leading cause of death in women
breast cancer
breast cancer accounts for more than _____% of cancers in women
10%
in the US. a women born now has a ___% or ___ in ____ lifetime risk of developing breast cancer
12%
1 in 8
95% of new breast cancers occur above the age of ____
40
factors which increase relative risk of breast cancer:
(this card is a lot but it is an LO so here I go)
page 412 in bates
>40 Relative Risk: factors are: female age inherited genetic mutations 2 or more first degree relatives with breast cancer diagnoses at an early age personal history of breast cancer high breast tissue density biopsy confirmed atypical hyperplasia
2.1-4.0 RR: factors are:
one 1st degree relative with breast cancer
high dose radiation to chest
high bone density (postmenopausal)
1.1-2.0 RR: factors are: late age at first full term pregnancy >30 early menarche (55) no full term pregnancies never breast fed a child recent oral contraceptive use recent and longterm use of hormone replacement therapy obesity
other factors: personal history of endometrium ovary or colon cancer alcohol consumption height high socioeconomic status jewish heritage
estimate absolute lifetime risk of breast cancer and are the most commonly used. they assess risk based on large population Data sets, BUT hey do not predict disease in a single individual.
Gail and CLaus models
used for predicting BRCA1 or BRCA2
BRCAPRO model
there is no single model that addresses all the known risk factors or includes all of the genetic details of personal and daily history, so devising data bases personalized management strategies is an on going focus for reseach
true
Breast cancer risk assessment tool often called the _____________ provides 5 year and first degree relatives with breast cancer previous breast biopsies and presence of hyperplasia, age at menarche, and age at first delivery. it is the best used for individuals over the age of 50 who have either no family history of breast cancer or one affected first degree relative and who have annual screening mammos. should not be used for women with a past history of breast cancer or radiation exposure, or those who are 35 or younger. does not determine risk for noninvasive breast cancer and does not take paternal history or disease in second degree relatives into account or age of onset of disease
this model was recently updated to include breast density but depends on the use of digital mammo and special software making it more difficult to use
GAIL MODEL
assess risk for high risk women and incorporates family history for both female And male 1st and 2nd degree relatives, including age of onset.
based on the woman’s current age
it is best used for individuals with no more than two first or second degree relatives with breast cancer.
expanded version includes family members with ovarian cancer,
model does not include personal, lifestyle or reproductive risk factors
discrepancies in risk assessment between published tables and the computerized program have been reported
CLAUS MODEL
used for high risk women to assess risk of BRACA1 and BRACA 2 mutations frequencies, cancer penetration i affected carriers and age of onset in first and second degree female and male relatives.
DOES NOT include on hereditary risk factors
BRCAPRO model
when do we begin evaluating a womans breast cancer risk?
early 20s by asking about family history
pattern of breast or ovarian in maternal or paternal family member is suspicious for
autosomal dominant genetic mutations
what do you loook specifically for in a positive family history
- age 50 or younger for diagnosis
- breast cancer in two or more indiv. in the same lineage (paternal or maternal)
- multiple primary or ovarian tumors in one person
- breast cancer in a male relative
- Ashkenazi Jewish ancestry
- family member with a known predisposing gene
what mutation represent roughly half of the familial breast cancers
BRCA1 and 2
account for 5% of breast cancers
if family history is suspect the next steps for clinical include
using the BRCAPRO calculator, conducting genetic testing, considering MRI for sceening in addition to mammo and making appropriate specialty referals
mammo women 40 to 50
controversial: why?
1. due to lower sensitivity and specificity
2. maybe related to heterogenous estrogen exposure in women still premenopausal
3. high number of false positives (9 out of 100 women)
4. high rate of resulting invasive procedures
having mammo 40-50 is based on individual patient
screening mammo age 50-74
biennial screening for women. changed it from annual to biennial.
reduced the harm of ammo screening. decreased false positives
however American cancer society and world health organization recommend annual mammo. world health organization says every 1 to 2 years.
digital mammo appears to perform better in younger women and women with higher breast density
screening mammos for over 75 yo
individualized decisions about continuing screening, depending on coexisting conditions and anticipated 5 year survival
Clinicial Breast Examination (CBE) guideleines
USPSTF and World Health Organization: determined evidence supporting insufficiency of CBE for establishing balance of benefits and harms
American Cancer Society recommends the CBE every 3 years for women ages 20-39 and annually preferably before mammo, beginning age 40. CBE provides pt education but cautions that a thorough CBE may take up to 10 min.
CBE is heavily influenced by the technique of the examiner.
Breast self exam contraversy
evidence that is does not reduce mortality and may lead to higher rate of benign biopsies
but some say it promotes health awareness and advises clinicians to teach and review the patient techniques.
monthly BSE 5 to 7 days after onset of menses (when hormonal stimulation of breast tissue is low) can be taught to women as early as their 20s
BSE instructions on how to perform. page 427 in bates
again this is long. but it is an LO so i would read it over :)
you can do it!
lying supine:
- lie down with a pillow under your right shoulder. lace right arm behind your head.
- use finger pads of the three middl fingers on your left hand to feel for lumps in the right breast. finger pads are the top third of each finger
- firmly press enough to know how your breast feels, using firmer pressure for tissue closest to the chest and ribs. firm ridge in the lower curve of each breast is normal. if you’re not sure how hard to press talk with provider. or try to cop the at they do it
- press firm on he breast in an up and down or strip patient. also can us a circular or wedge pattern but be sure to use the same pattern every time. check the entire breast area form the underarm tot he sternum and the collarbone to the ribs below the breast. remember how your breast feels from month to month
- repeat exam on your left breast
- if you fin a mass or lump or skin change go see your doctor DUH
Standing:
- while standing in front of a mirror with your hands pressing firmly down on your hips , look at your breasts and say…. I am beautiful hahaha!…. but for real look at your breasts for changes in size shape contour or dimpling or redness or scaliness of nipple or breast skin.
- examine each underarm while sitting up or standing and with your arm only slightly raised so you can easily feel in this area. raising arm straight up tightens he tissue in this area and makes it hard to examine.
breast MRI screening criteria
annual screening with MRI and mammo for women at high lifetime risk of breast cancer, above 20%. woen at moderate lifetime risk (15% to 20%)urged to discuss MRI screening with their provider.
high risk (20% -25%) criteria and factors for breast cancer and therefore indicated to get a breast MRI include
(5)
- lifetime risk 20-25% using assessment tools
- BRCA1 or 2 mutation
- 1st degree relative (father, brother, with BRCA1 or 2 mutation but woman not tested)
- history of chest radiation between ages of 10-30
- high risk genetic syndrome in 1st degree relative with high risk syndrome
moderate risk (15-20%)
3
- lifetime risk of 15-20% using risk assessment tools
- history of breast cancer, ductal or lobular carcinoma in situ, atypical ductal or lobular hyperplasia
- extremely dense breasts or unevenly dense breasts on mammograms
tunnel for the vas deferens as if passes through the abdominal mucles
inguinal canal
triangular, slitlike structure palpable just above and lateral to the pubic tubercle.
external inguinal ring
aprrox 1 cm above the midpoint of the inguinal ligament.
internal inguinal ring
what is not palpable through the abdominal wall relating to anatomy of the groin
canal nor internal ring
how are inguinal hernias formed
loops of bowel force their way through weak areas of the inguinal canal and produce inguinal hernias.
what is another route for a hernia mass
femoral canal
develop at the internal inguinal ring, where the spermatic cord exits the abdomen
indirect inguinal herniea
arise more medially from weakness in the floor of the inguinal canal and are associated with straining and heavy lifting
direct inguinal hernias
more present as emergencies with bowel incarceration or strangulation
femoral hernias
INGIRECT HERNIA frequency, age, sex point of origin course examination during straining
frequency, age, sex: all ages, both sexes. often children, may be adults
point of origin: above inguinal ligament, near its midpoint (internal inguinal ring)
course: often into the scrotum
examination during straining: the hernia comes down the inguinal canal and touches the finertips
DIRECT HERNIA frequency, age, sex point of origin course examination during straining
frequency, age, sex: less common, men older than 40; rare in women
point of origin: above inguinal ligament, close to the pubic tubercule (near the external inguinal ring)
course: rarely into the scrotum
examination during straining: the hernia bulges anteriorly and pushes the side of the finger forward
FEMORAL HERNIAS frequency, age, sex point of origin course examination during straining
frequency, age, sex: least common, more common in women
point of origin: below the inguinal ligament, appears more lateral than an inguinal hernia. can be hard to differentiate from lymph nodes
course: never into scrotum
examination during straining: inguinal canal is empty
may be from psychogenic causes, especially if early morning erection is reserved; it may also reflect decreased testosterone, decreased blood flow in the hypogastric arterial system, impaired neural innervation, and diabetes
erectile dysfunction
common in young men. possible causes are medications, surgery, neurologic deficits, lack of androgen.
premature ejaculation
lack or orgasm with ejaculation is usually
psychogenic
reduced or absent ejaculation affects
middle aged or older men
less common
yellow penile discharge
gonorrhea
white penile discharge
non gonococcal urethritis from chlamydia
rash, tenosynovitis, monoarticular arthritis, even meningitis, not always with urogenital symptoms
disseminated gonorrhea
what are the 4 infections from oral-penile transmission
- gonorrhea
- chlamydia
- syphilis
- herpes
tight prepuce that cannot be retracted over the glans.
phimosis
tight prepuce that once retracted cannot be returned edema ensues
paraphimosis
inflammation of the glans
blanitis
inflammation of the glans and prepuce
balanoposthitits
congenital, ventral displacement of the meatus on the penis
hypospadias
profuse yellow discharge
gonococcal urethritis
scanty white or clear discharge
nongonococcal urthritis
what is the definitive diagnosis required for gonococcal urthiritis and nongonococcal urthrititis
gram stain and culture
induration along the ventral surface of penis suggests
and tenderness in the indurated area suggest
urethral stricture or possibly carcinoma
periurethral inflammation secondary to urrthral structure
4 things that a tender, painful scrotal swelling could be
- acute epididymitis
- acute orchitis
- torsion of the spermatic cord
- strangulated inguinal hernia
multiple tortuous veins in this area, usually on the left, may be palpable and even visable
varicocele
vas deferens if infected may feel thickened or beaded. cystic structure in the spermatic cord suggests
hydrocele of the cord
bulge that appears with straining
hernia
how does bowel sounds help differentiate between a hernia and a hydrocele
bowel sounds may be heard over a hernia
bowel sounds are NOT heard over a hydrocele
when a hernias contents cannot be returned to the abdominal cavity
incarcerated
when a hernias blood supply to the entrapped contents is compromised
stangulated
hernia with tenderness, nausea, vomiting and consider surgical intervention
a. strangulation OR
b. incarcerated
A. STRAGULATION
what is the most common form of cancer for men between ages 15-34
testicular carcinoma
what are three conditions that have to do with penile discharge or lesions
p.535
i. Peyronie’s disease
ii. Hypospadias
iii. Carcinoma of the penis
palpable, non tender hard plaques are found just beneath the skin, usually along the dorsum of the penis. the pt complains of a rooked, painful erection
Peyronie’s disease
an indurated module or ulcer that is usually non tender. limited almost completely to me who re not circumcised, it may be masked by the prepuce. any persistent penile sore is suspicious
Carcinoma of the penis
congenital displacement of the urethral meatus to the inferior surface of the penis. a groove extends from the actual urethral meatus to its normal location on the top of the glans
Hypospadias
may make the scrotal skin taut, seen in heart failure or nephrotic syndrome
scrotal edema
pitting edema
non tender, fluid filed mass within the tunica vaginalis. it transilluminates and the examining fingers can get above the mass within the scrotum
hydrocele
usually an indirect inguinal hernia, that comes through the external inguinal ring, so the examining fingers cannot get above it within the scrotum
scrotal hernia
testis is atrophied and may lie in the inguinal canal or the abdomen, resulting in an unfilled scrotum. no palpable testis or epididymis on the affected side. raises the risk for testicular cancer
cryptorchidism
testicular length usually
small testis
testis is acutely inflamed, painful, tender, and swollen
may be difficult to distinguish from epididymis
scrotum may be reddened
seen in mumps an other viral infections usually unilateral
acute orchitis
usually appears as a painless nodule
any nodule within the testis warrants investigation for malignancy
EARLY tumor or the testis
painless nodule spreads, may seem to replace the entire organ. the testicle characteristically feels heavier than normal
LATE tumor of the testis
a painless, movable cystic mass just above the testis suggest a _____________ or _____________. both transilluminate.
which contains sperm
and then which dose not,
are they clinically indistinguishable.
Spermatocele or cysts of the epididymis
which contains sperm: spermatocele
which does not contain sperm: cysts of epididymis
YES they are clinically indistinguishable.
an acutely inflamed epididymis is tender and swollen and may be difficult to distinguish from the testis. the scrotum may be reddened and the vas deferens inflamed. it occurs chiefly in adults, most commonly with chlamydia infection. coexisting urinary tract infection or prostatitis supports the diagnosis.
acute epididymitis
refers to varicose veins of the spermatic cord, usually found on the left. it feels like a soft :bag of worms” separate from the testis, and slowly collapses when the scrotum is elevated in the supine patient. infertility may be associated.
varicocele of the spermatic cord
twisting of the testicle on its spermatic cord produces an acutely painful, tender, and swollen organ that is retracted upward in the scrotum. the scrotum becomes red and edematous. there is no associated urinary infection. most common in adolescents, is a surgical emergency because of obstructed ciruclation
torsion of the spermatic cord
the chronic inflammation produces a firm enlargement of the epididymis, which is sometimes tender, with thickening or beading of the vas deferens
tuberculous epididymitits
Appearance: single or multiple papules or plaques of variable shapes; may be round, acuminate (or pointed), or thin and slender. may be raised, flat or cauliflower-like
causative organism: human papillomavirus (HPV), usually subtypes 6 and 11, carcinogenic subtypes rare
incubation: weeks to months, infected contact may have no visible warts.
can arise on penis, scrotum, groin, thighs, anus, usually asymptomatic, occasional itching and pain
may disappear without treatment
genital warts (condylomata aciminatata)
appearance: small scattered or grouped vesicles, 1 to 3 mm in size, on glans or shaft of penis. appear as erosions if vesicular membrane breaks.
Causative organism: usually herpes simplex virus 2 (Double stranded DNA virus)
incubation: 2 to 7 days after exposure
primary episode may be asymptomatic; recurrence usually less painful of shorter duration.
associated with fever, malaise, HA, arthraligias, local pain and edema, lymphadenopathy
what do you need to distinguish this from (2)
genital herpes simplex
need to distinguish from genital herpes zoster (usually in older patients with dermatomal distribution); candidiasis.
appearance: small red papule hat becomes chancre, or painless erosion up to 2 cm in diameter. base of chancre is clean, red, smooth and glistening; borders are raised and indurated. chancre heals within 3 to 8 weeks.
causative organism: Treponema pallidium (spirochete
incubation: 9 to 90dyas after exposure
may develop inguinal lymphendopathy within 7 days; lymph nodes are rubbery, non-tender, mobile
20-30% of pt develop secondary syphilis while chancre still present (suggest co-infection with HIV)
what do you need to distinguish from (3)
primary syphilis
distinguish from:
- genital herpes simplex
- chancroid
- granuloma inguinale from Klebsiiella granulomatis (rare in US; 4 variants, so difficult to identify)
Appearance: red papule or pustule initially, then forms a painful deep ulcer with ragged non indurated margins; contains necrotic exudate has a friable base
causative organism: Haemophilus ducreyi, an anaerobic bacillus
Incubation: 3 to 7 days after exposure
painful inguinal adenopathy; suppurative buboes in 25% of pts
what do you need to distinguish from? (4)
chancroid
need to distinguish from:
- primary sphyilis
- genital herpes simplex
- lymphoomogranuloma venereum
- granuloma inguinale from Kelbsiella granulomatis (both rare in the US).
its incidence is low (4 per 100,000 men) BUT it is the most common cancer of young men between ages 15-34
testicular cancer
when detected early how is the prognosis of testicular cancer
GREAT!
what are risk factors for testicular cancer (5)
- cryptorchidism (which confers a high risk for testicular carcinoma in the undescended testicle)
- history of carcinoma in contralateral testicle
- mumps orchitis
- inguinal hernia
- hydrocele in childhood
Instructions for testicular self exam…
just read it over
p.531
best performed after a warm bath or shower. the heat relaxes the scrotum and makes it easier to find anything unusual
- standing in front of a mirror, check for any swelling on the skin of the scrotum
- with the penis out of the way, examine each testicle separately
- cup the testicle between your thumb and fingers with both hands and roll it gently between fingers. one testicle may be larger than the other; that is normal, but be concerned about any lump or area of pain.
- find the epididymis, this is a soft, tubelike structure at the back of the testicle that collects and carries sperm, and is not an abnormal lump.
- if you find any lump, dont wait. see a doctor. the lump may just be an infection, but if it is cancer, it will spread unless stopped by treatment
who is at highest risk of HIV/AIDS
african american men and men having sex with men.
testing for HIV (what age)
people at high risk: how often?
universal testing from ages 18-64, regardless of risk
groups at high risk: annually
presence of any STI (hep B chancroid etc) warrants testing for
coinfection of HIV
what type of approach is beneficial in adopting for take a sexual history
client centered counseling!
key instructions for using a condom correctly and therefore reducing the risk of STI and HIV (4)
- using a new condom with each sex act
- applying the condom before any sexual contact occur
- adding only water based lubricants
- holding the condom during withdrawal to keep it from slipping off.
what age is HPV vaccination for boys and men recommended.. and what does it prevent
GARDASIL for boys and men ages 9-26 for prevention of genital warts
what are you looking for when you retract the prepuce (foreskin)?
chancres and carcinomas.
can see smegma: cheesy, whitish material may accumulate normally under foreskin
dome-shaped white or yellow papules or nodules formed by occluded follicles filed with keratin debris of desquamated follicular epithelium
epidermoid cysts
change in bowel pattern, especially stools of thin pencil-like shape, may warn of
colon cancer
blood in the stool may be from
4
polyps or cancer or from gastrointestinal bleeding or local hemroids