C-en-es Flashcards
Hemangioblastoma at Cerebellum
Associated with renal cell carcinoma
Von hippel Lindau
Paraneoplastic syndromes in CNS
Lambert Eaton myasthenic syndrome - associated with lung cancer (small cell)
> voltage gated ca+ ch
ca+ , presynaptic
Myasthenia graves - thymomas
Gliomas
Astrocytomas
Oligodendrocytes
Ependymoma
Neuronaltumors
Gangliomas
Poorly differentiated cns tumors
Medulloblastoma
CNS astrocytoma
Hair like structure in microscope
Relatively benign behavior
WHO CLASS 1
Pilocytic astrocytoma
Pediatric age group
“Pilo - hair like structure “
Astrocytoma
Mc location : cerebral hemispheres
Relatively malignant behavior
Infiltrating astrocytoma
- Diffuse (2/4)
- Anaplastic (3/4) greater nuclear polymorphism
- Glioblastoma(4/4)-mc primary brain tumor in adult
Frontal -weakness of legs
Pariatal - language
Radiotherapy & resec
Similar to a aplastic but with NECROSIS AND VASCULAR/ENDOTHELIAL CELL PROLIFERATION
“Butterfly lesion” in the brain
“Pseudo-palisading”
GLIOBLASTOMA MULTIFORME
WHO (4/4)
Most aggressive
Structure that connects the 2 cerebral hemispheres
Corpus callousum
Fried egg appearance
Mc location : cerebral hemispheres - WHITE MATTER
PP : sheath of irregular cells with spherical nuclei surrounded by clear halo
Oligodendroglioma
Mc CNS neoplasm associated with AIDS ,transplant,
EBV,marker = CD20
most common : DIFFUSE B CELL LYMPHOMA
Primary CNS lymphoma
Fever,rash, cervical and axillary LN Enlargement,hepato and splenomegaly
Heterophil (+)
Sore throat
Kissing disease
Infectious mononucleosis
Benign tumors of adult Attached to dura,meningothelial cells Rf = prior radiotherapy Associated with NEUROFIBROMATosIS 2 Psammoma bodies Atypical and anaplastic - most aggressive
MENINGIOMA
Mc site : parasagittal aspect ,dura over lateral con exits,sella Turkic a,f. Magnum,sphenoid wing
Foster Kennedy syndrome
Meningioma at olfactory groove
3 tumors with PSAMMOMA BODIES
Ovarian cyst-adenocarcinoma
Papillary thyroid cancer
Meningioma
Dural tail sign
Meningioma radiologic findings
Ash leaf spots Shagreen patch Heart rehabdomyosarc Lung hamartoma Epilepsy Angiomyolipoma Facial angiofibroma
TUBEROUS SCLEROSIS
NEUROFIBROMATosIS 1 :
NEUROFIBROMATosIS 2
- NEUROFIBROMA - peripheral nerve & optic nerve
> linchpin nodules
> cafe au lait - Bilateral acoustic neuroma
Multiple meningioma
SC EPENDYMoma