Buzzwordy things Flashcards
Describe Cross sectional
looks at data in one group at a given time
q: What is happening right now?!?!
a: shows risk factor association but not causality
measures DISEASE PREVELANCE
Describe Case control
odds ratio
what happened?
looks at people with dz now to see what rf/exposures they had before
Describe Cohort study
relative risk
who will or who did get disease?
looks at people with rf now to see if they will or if they did get the diesase
Three thigns that increase quality of a clinical study
randomized
controlled
double blind
describe triple blind
1) pt doesnt know if getting tx or placebo
2) dr doesnt know if pt getting tx or placebo
3) researcher analyzing data doesnt know which patients got tx and which got placebo
what is measured in phase one
is it safe?
safety, toxicity, PK and PD
what is measured in phase two
does it work?
efficacy, dosing, a/se
what is measured in phase th ree
is it the same or better?
new vrs standard of care tx
what is measure in phase four
can it stay?
long term and/or rare effects
can result in tx being pulled from market
Define: selection bias
error ir assigning subjects to a study group resulting in an unrepresetnative sample
How to decrease selection bias
randomize
ensure choice of the right comparison reference group
Define: recall bias
awareness of disorder alters recall by subjects; common in retrospective studies (case control, can be cohort)
How to decrease recall bias
decrease time from exposure to follow up
Define: measurement bias
information is gathered in a way that distorts it. ie crappy machinery
How to decrease measurement bias
use standardized method of data collection
Define: procedure bias
subjects in different groups are not treated the same ie ppl with dz will be in hospital
How to decrease procedure bias
blind and use placebo - reduces influece of ppts and researchers on procedures and interpretation of otucomes bc will not be aware of allocations of tx/placebo
** same as observer-expectancy bias
Define: observer-expectancy bias
researcher’s belief in the efficacy of a treatment changes the outcome of that treatment
ex: pygmalion effect/self-fulfilling prophecy