Buzzwords

Question 0

Blasts predominate
Affect children or elderly
Short and drastic course

What type of leukemia? Acute or chronic?

Answer 0

Acute leukemia

Question 1

Abnormal azurophilic granules

Patches of dilated ER that appear as sky blue cytoplasmic puddles

Answer 1

Dohle bodies

Leukocytosis

Question 2

More mature cells
Midlife age range affected
Longer, less devastating course

Answer 2

Chronic leukemia

Question 3

More condensed chromatin
Less conspicuous nucleoli
Smaller cytoplasm

Answer 3

Lymphoblast

Question 4

Hyper cellular marrow with lymphoblasts
MPO negative
PAS positive
CD 10, 19, 22 positive
t(12;21)
Most responsive to chemo

Answer 4

ALL

Question 5

ALL chemo drug

Answer 5

L- Asparaginase

using ommaya reservoir

Question 6

>20% myeloblasts in BM
Auer rods
MPO positive
CD 33, 34 positive
Pancytopenia
Spontaneous mucocutaneous bleeding

Answer 6

AML

Poor prognosis

Question 7

Only human can that can be treated with vitamins
Most numerous Auer rods
t(15;17)

Answer 7

APML

Highest incidence of DIC

Question 8

t(9;22)
< 10% myeloblast
Sea blue histiocytes
Wrinkled green blue cytoplasm
Blast crisis

Answer 8

CML

Question 9

10-19% myeloblast
> 20% basophils
Platelet  1,000,000 and unresponsive
New cytogenetic abnormalities
Increasing splenomegaly

Answer 9

Accelerated Phase of CML

Question 10

Myeloblasts less than 10% of circulating cells
Very low leukocyte alkaline phosphatase
WBC >100,000
Scattered macrophages with green blue cytoplasm

Answer 10

CML

Question 11

> 20% myeloblasts or lymphoblasts
Large clusters of blasts in BM
Chloroma developed

Answer 11

CML Blast crisis

Question 12

Treatment for CML

Answer 12

Imatinib

Question 13

Diffuse lymphadenopathy
Smudge cells
Elderly

Answer 13

CLL

Question 14

Fine hairlike projections
Stained using tartate resistant acid phosphatase
Mature b cell tumor

Answer 14

Hairy cell Leukemia

Question 15

Associated with EBV
Localized, single group of nodes
Contiguous spread
Bimodal age distribution

Answer 15

Hodgkins Lymphoma

Tx: ABVD

Question 16

Associated with EBV
Multiple, peripheral nodes
Extranodal involvement
Affects 20-40 years old

Answer 16

Non Hodgkin lymphoma

Tx: CHOP

Question 17

Large cells with multiple nuclei or a single nucleus with multiple lobes

Answer 17

Reed Sternberg Cells

Question 18

Which Hodgkin lymphoma has poor prognosis? Excellent?

Answer 18

Poor - lymphocyte depleted

Excellent - nodular sclerosis, lymphocyte rich and lymphocyte predominant

Question 19

Popcorn cells

Answer 19

Lymphocyte predominant Hodgkin lymphoma

Question 20

t(14:18)
Centrocytes and centroblasts
In curable waxing and waning course
May transform to diffuse large b cell lymphoma
Angulated groove cells

Answer 20

Follicular lymphoma

Question 21

Translocation on chromosome 8
Starry sky pattern
Nuclear remnants are phagocytized by interspersed macrophages

Answer 21

Burkitt Lymphoma

Question 22

t (11;14)
Express high levels of cyclin D1
Deeply cleaved lymphoblasts

Answer 22

Mantle cell Lymphoma

Question 23

Neoplasm of CD4 cells
Skin lesions, generalized LAD
Clover leaf or flower cells

Answer 23

Adult t cell lymphoma

Question 24

Diffuse erythema and scaling of the entire body (Sezary syndrome)
Pautier microabscess
Sezary-lutzer cells

Answer 24

Mycosis Fungoides

Question 25

Lytic bone lesions
Mott cells, flame cells, Russell bodies - pink cytoplasmic inclusions, Dutcher bodies - blue nuclear inclusions
M protein
Monoclonal gammopathy

Answer 25

Multiple Myeloma

Question 26

Ringed sideroblasts, iron laden macrophages
Pseudo pelger huet cells
Pawn ball megakaryocyte
High risk to become AML

Answer 26

Myelodysplastic syndrome