Buzz Words 1 Flashcards
Pancytopenia, Hx of radiation, Down syndrome
ALL
Pancytopenia, Auer rods, DIC
AML
WBC>100,000, blast crisis, Splenomegaly
CML
Male, Lymphadenopathy, Infection, SMUDGE cells, Splenomegaly
CLL
Plaque like itchy skin BS: w/ cerebriform nuclei Pautrier microabscess
Mycosis Fungoides
RS cells, night sweats cervical lymphadenopathy
Hodgkins lymphoma
Small follicular= best prognosis
Large diffuse = worst prognosis
NonHodgkins lymphoma
Anemia, teardrop, dry tap on BM, assoc w/ CML, High RDW MCV
Myelofibrosis
Folicular Lymphoma
T (14,18)
Burkitt’s lymphoma
T (8,14)
Mantle lymphoma
T (11, 14)
Presence of proliferation centers
Smudge cells
CLL
Presence of Centrocytes, Centroblasts
Follicular Lymphoma
Difference bet Leukomoid reaction from CML
Leukomoid rx >50,000 High leukocyte alkaline phosphatase
CML >50,000 Low leukocyte alkaline phosphatase
Primary chemotherapeutic drug for ALL & AE
Asparaginase (pancreatitis)
Primary chemotherapeutic drug for CML & AE
Imatinib (Fluid retention, CHF)
Plasmacytoma, bizarre, multinucleated cells, flame cells, mott cells, russell bodies, dutcher bodies, rouleaux conformation
Multiple myeloma
Multiple Myeloma
Monoclonal M protein spike; IgM Hypercalcemia Renal Insufficiency Anemia Bone lytic lesions/ Bone pain
Ringed sideroblasts, Pseudopelger-huet cells, pawn ball megakaryocytes
Myelodysplastic syndrome
Fibrotic obliteration of marrow space; Osteosclerosis; Leukoerythroblastosis; Teardrop cells/dacryocytes
Primary Myelofibrosis
Proliferative disorder of dendritic cells
Birbeck granules
Langerhans cell Histiocytosis
Letterer-Siwe disease
Gandy-Gamna nodules
Congestive Splenomegaly
Lobulated, firm, gray-white masses
Swirling pattern of spindle-shaped cells; assoc w/ myasthenia gravis;
Paraneoplastic syndrome is Pure red cell aplasia
Thymoma
Normoblasts, Reticulocytosis, Cholelithiasis
Hemolytic anemias
Mutations of ankyrin, band 3, spectrin, band 4.2
spherocytes, splenomegaly
Hereditary Spherocytosis
Heinz bodies and Bite cells
G6PD deficiency
Sickled cells, Reticulocytosis,
Target cells (Codocytes), Howell jolly bodies
Autosplenectomy
Sickle Cell Anemia
Target cells (codocytes)
Basophilic stippling, Anisocytosis, Poikilocytosis,
Microcytic and hypochromic anemia
Thalassemia
Autoimmune Hemolytic anemia associated with IgG
Warm agglutinin
Autoimmune Hemolytic anemia associated with IgM
Cold agglutinin
Mycoplasma, mononucleosis
Macro-ovalocytes, Hypersegmented neutrophils
Megaloblastic anemia
Atrophy of fundic glands, intestinalization, atrophic glossitis
Pernicious anemia
Conditions with basophilic stippling
Thalassemia, Anemia of chronic disease, IDA, Lead poisoning
Hypocellular bone marrow with fat cells
Normocytic, normochromic anemia
Aplastic anemia
Mucosal bleeding, previously healthy individual, Spontaneous resolution
ITP
Hx of Thrombosis FAT RN
TTP
GP 1B platelet adhesion; Platelet decrease
Bernard Soullier
GP IIB/IIIA platelet aggregation; Platelet normal
Glanzmann’s thrombasthenia
MC inherited bleeding disorder; Hx of patient who has spontaneous bleeding but more commonly, trauma (dentist, nadapa) & wont stop bleeding but no hx of joint immobility
Von Willebrand factor disease
Hx of consaguinity X linked recessive severe bleeding d/o
Hemophilia
Child w/ diarrhea for several days presenting w/ frequent nosebleeding & gumbleeding; Prolonged PT/PTT
Vit K deficiency
Increase fibrinogen, pregnant px w/ FDU
Septic patient who is bleeding all over
DIC
