Burkitt's Lymphoma (Nucleus)

Question 1

Where is the perinuclear space?

Answer 1

B/t INM and ONM, and is often continuous w/ some RER cisternae

Question 2

What is the number of nuclear pores (10-30% of surface area) directly related to?

Answer 2

Transcriptional activity

Question 3

Is euchromatin condensed or dispersed? transcriptionally active or inactive?
Heterochromatin active/inactive, condensed/dispersed?

Answer 3

Euchromatin = dispersed and transcriptionally active
Heterochromatin = highly condensed and transcriptionally inactive

Question 4

Is constitutive heterochromatin always condensed or can be dispersed as needed? Facultative condensed/dispersed as needed?

Answer 4

constitutive = always condensed
facultative = dispersed as needed

Question 5

True or False, 46 threads that make up a chromosome are commonly seen in a cell’s nucleus?

Answer 5

False; Only seen during nuclear division

Question 6

What is the term when a gametic cell divides? When a somatic cell divides?

Answer 6

Gametic cell division = meiosis

Somatic division = mitosis

Question 7

What are the proteins called that control the cell cycle?

Answer 7

Cyclin-dependent kinases, which are controlled by cyclins, which are controlled by mitogens

Question 8

What stage of interphase do mose of our cells live their lives?

Answer 8

G1 (growth and normal metabolic roles)

*longest phase

Question 9

Is the cell life cycle/transition between phases unregulated, slightly regulated, or highly regulated?

Answer 9

Highly regulated

Question 10

Which phase is the slowest phase in Mitosis?

Answer 10

Prophase

Question 11

During prophase, what are are chromatids held together at centromere by?

Answer 11

2 protein kinetochores

Question 12

What are the 3 kinds of microtubules that make up the spindle apparatus?

Answer 12

Astral microtubules (star like at each end)
Kinetochore (from centrosome to kinetochore)
Polar microtubules (from centrosome to other centrosome)

Question 13

What does “ras” code for? What does “erb” code for?

Answer 13

ras codes for a mutant G-protein that binds GTP but can’t cleave to GDP, so it stays on
Erb codes for a damaged epidermal growth factor so it does not require the growth factor to function, so it’s on all the time

Question 14

Burkitt’s lymphoma is a disease caused from?

Answer 14

Failure in nucleus. Some DNA is corrupted by translocation (chromosomes 8 & 14) and looses control of cell division