Bulimia Nervosa Flashcards

1
Q

What is bulimia nervose (BN)?

A

Bulimia nervosa (BN) is an eating disorder characterized by repeated episodes of uncontrolled binge eating followed by compensatory weight loss behaviours and overvalued ideas regarding ‘ideal body shape/weight’.

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2
Q

Briefly describe the pathophysiology and aetiology of BN

A

The aetiology of BN is very similar to AN, but whereas there is a clear genetic component in AN, the role of genetics in BN is unclear.

When patients with BN binge due to strong cravings, they tend to feel guilty and as a result undergo compensatory behaviours such as vomiting, using laxatives, exercising excessively and alternating with periods of starvation.

This may result in large fluctuations in weight, which reinforce the compensatory weight loss behaviour, setting up a vicious cycle

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3
Q

Who is commonly affected by BN?

A

BN typically occurs in young women.

The estimated prevalence in women aged 15– 40 is 1– 2%.

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4
Q

How does socioeconomic class affect BN?

A

Whereas AN is thought to be more prevalent in higher socioeconomic classes, BN has equal socioeconomic class distribution.

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5
Q

What are the predisposing factors of BN?

Note: biological, psychological and social

A

Biological

  • Female sex
  • Family history of eating disorder, mood disorder, substance misuse or alcohol abuse
  • Early onset of puberty
  • Type 1 diabetes
  • Childhood obesity

Psychological

  • Physical or sexual abuse as a child
  • Childhood bullying
  • Parental obesity
  • Pre-morbid mental health disorder
  • Preoccupation with slimness
  • Parents with high expectations
  • Low self-esteem

Social

  • Living in a developed country
  • Profession (e.g. actors, dancers, models and athletes)
  • Difficulty resolving conflicts
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6
Q

What are the precipitating factors of BN?

Note: biological, psychological and social

A

Biological

  • Early onset of puberty/ menarche

Psychological

  • Perceived pressure to be thin may come from culture (e.g. Western society, media and profession)
  • Criticism regarding body weight or shape

Social

  • Environmental stressors
  • Family dieting
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7
Q

What are the perpetuating factors of BN?

Note: biological, psychological and social

A

Biological

  • Co-morbid mental health problems

Psychological

  • Low self-esteem, perfectionism
  • Obsessional personality

Social

  • Environmental stressors
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8
Q

What other psychiatric conditions are co-morbid with BN?

A

BN commonly co-exists with the following psychiatric disorders and it is hence important to screen for them:

  1. Depression
  2. Anxiety
  3. Deliberate self-harm
  4. Substance misuse
  5. Emotionally unstable (borderline) personality disorder
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9
Q

Briefly describe the ICD-10 Criteria for diagnosing BN

Note: Bulimia Patients Fear Obesity

A
  1. Behaviours to prevent weight gain (compensatory): compensatory weight loss behaviours include: self-induced vomiting, alternating periods of starvation drugs (laxatives, diuretics, appetite suppressants, amphetamines, and thyroxine) and excessive exercise.
  2. Preoccupation with eating: a sense of compulsion (craving) to eat which leads to bingeing. There is typically regret or shame after an episode.
  3. Fear of fatness: including a self-perception of being too fat.
  4. Overeating: at least two episodes per week over a period of 3 months.
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10
Q

How may diabetics present with BN?

A

Diabetics may omit or reduce insulin dose.

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11
Q

Other than those stated in the ICD-10 Criteria, what are the other features of BN?

A
  • Normal weight
    • Usually the potential for weight gain from bingeing is counteracted by the weight loss/purging behaviours.
  • Depression and low self-esteem
  • Irregular periods
  • Signs of dehydration
    • ↓ blood pressure, dry mucous membranes, ↑ capillary refill time, ↓ skin turgor and sunken eyes
  • Consequences of repeated vomiting and hypokalaemia
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12
Q

What are the 2 subtypes of BN?

A

There are two subtypes of BN:

  1. Purging type: the patient uses self-induced vomiting and other ways of expelling food from the body, e.g. use of laxatives, diuretics and enemas.
  2. Non-purging type: much less common. Patients use excessive exercise or fasting after a binge. Purging-type bulimics may also exercise and fast but this is not the main form of weight control for them.

Note: the ICD-10 does not differentiate between the two types

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13
Q

Briefly differentiate between BN and anorexia nervosa

A

Anorexia nervosa

  • Amenorrhoea
  • No friends (socially isolated)
  • Obvious weight loss
  • Restriction of food intake
  • Emaciated
  • Xerostomia (dry mouth)
  • Irrational fear of fatness
  • A bnormal hair growth (lanugo hair)

Bulimia nervosa

  • Binge eating
  • Use of drugs to prevent weight gain
  • Low potassium
  • Irregular periods
  • Mood disturbances
  • Irrational fear of fatness
  • Alternating periods of starvation
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14
Q

Briefly describe hypokalaemia in BN and how it’s treated

A

A potentially life-threatening complication of excessive vomiting.

Low potassium (<3.5 mmol/L) can result in muscle weakness, cardiac arrhythmias and renal damage.

Mild hypokalaemia requires oral replacement with potassium-rich foods (e.g. bananas) and/or oral supplements (Sando-K). Severe hypokalaemia requires hospitalization and intravenous potassium replacement.

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15
Q

Briefly describe the MSE of BN

A

Appearance and behaviour: may have appearance and behaviour consistent with depression or anxiety. Signs include likely normal weight, parotid swelling, Russell’s sign and sunken eyes (dehydration).

Speech: slow or normal.

Mood: low.

Thought: preoccupation with body size and shape, preoccupation with eating and guilt.

Perception: normal.

Cognition: either normal or poor.

Insight: usually has good insight.

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16
Q

What investigations should be ordered for BN?

A

Blood tests:

  • FBC
  • U&Es
  • Amylase
  • Lipids
  • Glucose
  • TFTs
  • Magnesium
  • Calcium
  • Phosphate

Venous blood gas: may show metabolic alkalosis.

ECG: arrhythmias as a consequence of hypokalaemia (ventricular arrhythmias are life threatening), classic ECG changes (prolongation of the PR interval, flattened or inverted T waves, prominent U waves after T wave).

17
Q

What are the cardiovascular complications of repeated vomiting?

A
  • Arrhythmias
  • Mitral valve prolapse
  • Peripheral oedema
18
Q

What are the GI complications of repeated vomiting?

A
  • Mallory– Weiss tears
  • ↑ size of salivary glands especially parotid
19
Q

What are the metabolic/ renal complications of repeated vomiting?

A
  • Dehydration
  • Hypokalaemia
  • Renal stones
  • Renal failure
20
Q

What are the dental complications of repeated vomiting?

A
  • Permanent erosion of dental enamel secondary to vomiting of gastric acid
21
Q

What are the endocrine complications of repeated vomiting?

A
  • Amenorrhoea
  • Irregular menses
  • Hypoglycaemia
  • Osteopenia
22
Q

What are the dermatological complications of repeated vomiting?

A
  • Russell’s sign (calluses on back of hand due to abrasion against teeth)
23
Q

What are the pulmonary complications of repeated vomiting?

A
  • Aspiration pneumonitis
24
Q

What are the neurological complications of repeated vomiting?

A
  • Cognitive impairment
  • Peripheral neuropathy
  • Seizures
25
Q

What is shown in the images A, B and C?

A

Complications of repeated vomiting.

A= Russell’s sign

B= Bilateral parotid swelling

C= Dental erosion

26
Q

Briefly describe the bio-psychosocial model of managing BN

A

Biological

  • A trial of antidepressant should be offered and can ↓ frequency of binge eating/ purging. Fluoxetine (usually at high dose, 60 mg) is the SSRI of choice.
  • Treat medical complications of repeated vomiting, e.g. potassium replacement
  • Treat co-morbid conditions.

Psychological

  • Psychoeducation about nutrition, CBT for bulimia nervosa (CBT-BN is a specifically adapted form of CBT)
  • Interpersonal psychotherapy is an alternative

Social

  • Food diary to monitor eating/purging patterns, techniques to avoid bingeing (eating in company, distractions), small, regular meals and self-help programmes
27
Q

When is inpatient treatment for BN required?

A

Inpatient treatment is required for cases of suicide risk and severe electrolyte imbalances.

28
Q

Why is the Mental Health Act (MHA) not usually required in BN?

A

The Mental Health Act is not usually required, as BN patients have good insight and are motivated to change.

29
Q

What is the prognosis of BN?

A

Approximately 50% of BN patients make a complete recovery in comparison with AN where roughly 20% make a full recovery.

30
Q

What differentials should be considered for BN?

A
  • Anorexia nervosa with bulimic symptoms
  • EDNOS (Eating Disorder Not Otherwise Specified)
  • Kleine- Levin syndrome
    • Sleep disorder in adolescent males characterised by recurrent episodes of binge eating and hypersomnia
  • Depression
  • Obsessive- compulsive disorder
  • Organic causes of vomiting e.g. gastric outlet obstruction