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ADAM Microbiology FA > Bugs with exotoxins (p.124) > Flashcards

Bugs with exotoxins (p.124) Flashcards

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1
Q

These 2 inactivate Elongation factor

A

C. diptheria, pseudomonas aeruginosa

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2
Q

This causes severe LAD (bull neck)

A

C. diptheria

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3
Q

The exotoxins for these 4 bugs inhibit protein synthesis

A
  1. C. diptheria
  2. pseudomonas aeurginosa
  3. Shigella
  4. EHEC 0157:H7
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4
Q

These 2 inactivate 60S ribosome

A

Shigella, EHEC 0157:H7

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5
Q

This toxin invades the GI mucosa, can cause HUS, enhances cytokine release

A

Shiga Toxin

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6
Q

This toxin does NOT invade the GI mucosa, can cause HUS, enhances cytokine release

A

SLT (from EHEC)

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7
Q

These 4 are cAMP inducers in the GI

A
  1. Bordetella pertussis
  2. ETEC: LT, ST
  3. Bacillus anthracis
  4. Vibrio cholera
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8
Q

Increased cAMP in the GI has what effect?

A

THE D-diarrhea

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9
Q

What is the bug associated with LT and ST

A

ETEC

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10
Q

Difference between MOA of LT and ST

A

LABILE in the Air; STABLE on the Ground

A for cAMP; G for cGMP

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11
Q

This exotoxin causes black eschar

A

Edema factor (anthrax)

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12
Q

Pt presents with “rice water” diarrhea. What is the 1. bug and 2. toxin and 3. MOA of toxin

A
  1. Vibrio Cholera
  2. cholera toxin
  3. permanently activating Gs for cAMP
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13
Q

5yo pt presents with a cough on expiration and a “Whoop” with inspiration. What is the 1. Bug 2. MOA of the toxin

A
  1. Bordetella pertussis

2. disables Gi for cAMP, impairs phagocytosis

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14
Q

What are the 1. bugs and 2. toxins for the only neurotoxin microbes?

A
  1. Clostridium tetani and Clostridium botulinum

2. Tetanospasmin and Botulinum toxin

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15
Q

Different MOA of tetanospasmin and botulinum toxin

A

tetanospamin blocks release of inhibitory GABA/Glycin

Botulinum toxin blocks release of stimulatory ACh

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16
Q

Pt presents with “Gas gangrene”. What is the 1. bug 2. toxin and 3. MOA of toxin for this pt.

A
  1. Clostridium perfringens
  2. Alpha toxin
  3. degradation of phospholipid C–>myonecrosis
17
Q

This 1. bug and 2. toxin that lyses RBC membranes

A
  1. Strep pyogenes

2. Streptolysin O

18
Q

How do superantigens cause shock?

A

Overstimulation of the immune system: cause overwhelming release of IFN-gamma and IL-2 via MHC II and TCR

19
Q

What are the 2 bugs and toxins that cause super antigenic shock?

A
  1. S. aureus–>TSST-1

2. S. pyogenes–>Exotoxin A

ADAM Microbiology FA (1 decks)

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