Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Bugs and Drugs Exam 2 > Bugs and MOR > Flashcards

Bugs and MOR Flashcards

1
Q

MSSA

A

-NSBLs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MRSA

A
  • NSBLs
  • modified PBPs
  • only requires single point mutation and high mutation rate to FQs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MSSE

A
  • 90% make NSBLs

- empirically assume it’s MRSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

MRSE

A
  • NSBLs

- modified PBPs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

PSSP

A

-don’t make beta-lactamases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

PRSP

A

-don’t make beta-lactamases
-modified PBPs
functionally resistant
*very slow mutation rate to develop FQ resistance…not a lot of gyrase resistance. Main target is PAR for FQ…main resistance is efflux pumps!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Any other streptococci

A
  • no beta-lactamases

- strep. viridans most resistant of these

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Enterococcus faecalis

A
  • no beta-lactamases
  • modified PBPs
  • VRE=modified PTG to become vancomycin resistant
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Enterococcus faecium

A
  • no beta-lactamases
  • modified PBPs
  • VRE=modified PTG to become vancomycin resistant
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Listeria monoctyogenes

A
  • no beta-lactamases
  • modified PBPs
  • PBPs are similar to enterococci but their ribosome is more similarto traditional G+ bugs (so macrolides work)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Corynebacterium

A

-modified PBPs (similar to enterococci)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Bacillus

A

-no beta-lactamases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Acinetobacter

A

-modified PBPs
-modified pores
-70-90% make BSBL
-some can make carbapenamases
only requires single point mutation and high mutation rate to FQs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Moraxella catarrhalis

A
  • “simple G-“

- 20-50% make BSBL (up to 75%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Neisseria gonorrhea

A
  • 20-50% make BSBL

- some have modified PBP–>if it does, NO penicillin will work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Neisseria meningitidis

A
  • “simple G-“
  • no beta-lactamases
  • some have modified PBPs (PRNM)
  • vaccine available!
17
Q

Haemophilus influenza

A
  • “simple G-“
  • 20-50% make BSBL
  • vaccine available!
  • many strains (<50% but still significant) have become resistant to marcolides via mef genes
18
Q

Pasturella/Eikenella

A
  • “simple G-“

- no beta-lactamases

19
Q

Escherichia coli

A
  • 20-50% make BSBL
  • possible to make IRBSBL which chops up ALL penicillins
  • 20% make ESBL (more likely to see in hospital infections)
  • requires multiple mutations and relatively slow rate of mutation for FQ resistance
20
Q

Salmonella

A

-20% make BSBLs

21
Q

Shigella

A

-20% make BSBLs

22
Q

Proteus mirabilis

A
  • least likely to make beta-lactamases

- -if it does make one, it’s BSBL

23
Q

Proteus vulgaris

A
  • most make BSBL

- modified PBPs

24
Q

Klebsiella

A
  • 70-90% make BSBL
  • 20% make ESBL
  • some make carbapenamases
25
Q

Citrobacter (Morganella, Providencia)

A
  • 70-90% make BSBL

- 20% make AmpC but this gene is usually repressed

26
Q

Enterobacter

A
  • 70-90% make BSBL
  • 20% make AmpC but gene usually repressed
  • some make carbapenamases
27
Q

Serratia

A
  • 70-90% make BSBL
  • 20% make AmpC but gene usually repressed
  • some make carbapenamases
28
Q

Pseudomonas aeruginosa

A

-restrictive outer membrane
-70-90% make BSBLs
-20% make AmpC
-some make carbapenamases
-unique PBPs
some resistance by modified porins to Aztreonam
*only requires single point mutation and high mutation rate to FQs…get end treatment resistance!!

29
Q

Stenotrophomonas maltophilia

A

-make carbapenamases

30
Q

Burkholderia cepacia

A

-multiple MOR

31
Q

Legionella pneumophilia

A
  • “simple G-“

- low affinity PBPs

32
Q

Bacteroides fragilis

A

-70-90% make BSBL

33
Q

Clostridium

A

-no beta-lactamases

34
Q

Clostridium difficile

A
  • does make beta-lactamases

- has spores

35
Q

Peptostreptococcus, Propionibacterium

A

-no beta-lactamases

36
Q

Mycoplasma

A

-no cell wall

37
Q

Mycobacteria

A

-acid fast

38
Q

Campylobacter jejuni

A

*requires multiple mutations and relatively slow rate of mutation for FQ resistance

Bugs and Drugs Exam 2 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions