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1
Q

Epidermal melanin unit.

A

1:36

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2
Q

Epidermal turnover time.

A

56 days

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3
Q

Granules present in Stratum lucidum

A

Eledin granules

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4
Q

Granules in stratum granulosum.

A

Keratohyaline(fillagrin)
Lamellar bodied/odland bodies

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5
Q

Cells in stratum spinosum

A

APC - Langerhans cells (CD 207)
BM- MACROPHAGES

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6
Q

Cells in str Basale

A

Merkel cells
Melanocytes

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7
Q

Merkel cells

A

Ectodermal
SALT RECEPTOR
CK 7- CK 20 +

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8
Q

Melanocytes

A

Neural crest cell derivative
S-100,Melan A, HMB 45

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9
Q

Define parakeratosis
Seen in

A

Psoriasis

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10
Q

Hyperkeratosis seen in

A

Psoriasis, LP

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11
Q

Orthokeratosis seen in

A

Hyper-para
LP

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12
Q

Hp of Psoriasis

A

●Hyperkeratosis
●Parakeratosis
●Club shaped rete ridges
●Munro’s microabsess in str corneum
●Spongiform pustules of kogoj in spinous or granular layer

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13
Q

Hp of Lichen planus

A

●Orthokeratosis
●Hypergranulosis
●Max Joseph space-wickham striae
●Civatte bodies
●Saw tooth appearance of Rete ridges
●Lichenoid band of inflammation

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14
Q

Erythema Nodosum seen in

A

Sulpha drugs
Sarcoidosis
(Loefgren syndrome)
IBD/TB/ BEHCET’s

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15
Q

Erythema Marginatum

A

ARF

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16
Q

E multiforme

A

Hsv mycoplasma
Chloroquine
NSAIDS

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17
Q

E migrans in

A

Lyme’s disease

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18
Q

Erythema seen in Paraneoplastic syndrome

A

E. Gyratum ripens

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19
Q

Skin and nail fx of psoriasis

A

Erythematous papulo squamous lesion with silvery scales
Irregular pitting
Oil drop pattern(pathognmonic)
Subungal hyperkeratosis
Splincter h’age

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20
Q

Grattage test done for

A

Psoriasis (auspitz sign positive)
Also ass with berkeley membrane

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21
Q

Psoriasis with h/o URTI and raindrop pattern lesion over trunk?

A

Guttate psoriasis
DOC Macrolides

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22
Q

H/o sudden withdrawl of steroids

A

Pustular psoriasis
Doc- Acitretin(washout period- 3 yrs)
K/a Impetigo herpetiformis in pregnancy

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23
Q

Koebner phenomenon
Seen in

A

Morphologically similar lesion on trauma
Seen in LPV(LP, PSORIASIS,VITILIGO)

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24
Q

Pseudo koebner

A

Auto innoculation
Seen in Viral warts(HPV, Mol contagiosum)

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25
Q

Reverse koebner

A

Lesion heals on trauma
Psoriasis

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26
Q

LP featured

A

Purple
Pruritic
Papule
Plane topped
polygonal
Pup tentibg
On plexors
Pterigium of nails
With wichham striae

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27
Q

Hp fx of lichen nitidus

A

Claw clutching a ball pattern

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28
Q

P rosea fx?

A

Christmas tree pattern
Ass with HHV 6/7
Herald patch ( cigarette paper with colarette scales)
Spares palms and soles
Rx Reassurance

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29
Q

P versicolor

A

Hypo + Hyperpigmented lesion
M. Furfur fungi -fried egg colonies
On KOH mount- sphagetti and meatball pattern

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30
Q

Fried egg appearnce seen in

A

M. Furfur
Mycoplasma
HC leukemia
Oligodendroma

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31
Q

Reiter sx

A

Occurs after pre-existing GI/ STD
Infection by Campylobacter/ shigella.
Can’t see(conjunctivitis)
Can’t pee(urethritis)
Can’t climb a tree (arthritis)

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32
Q

Two tough names ass with reiter sx

A

Keratoderma blenorrhagicum
Circinate balanitis

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33
Q

Bullous impetigo caused by

A

Staph- SSSS, SJS/TEN

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34
Q

Erisipelas

A

Caused by strep
Well defined
Raised lesion (st antony fire)
Upper 1/2 dermis + lymphatics involved

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35
Q

Cellulitis

A

Diffuse
Lower half of dermis + sc tissue involved

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36
Q

Meleney gangrene

A

Infn of surgical wound
Orange burrowing lesion

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37
Q

Erythrasma caused by

A

C. Minutissimum
On wood’s lamp - coral red

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38
Q

Ca ATPase 2A2 defect

A

Darrier’s ds
V shaped nail defect

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39
Q

Ca ATPase 2C1 defect

A

Hailey hailey ds
Longitudinal lines seen on nails
Hp: delapidated brick wall appearance

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40
Q

Scarring alopecia is seen in

A

Tinea capitis
Lp
DLE
+- sec syphillis

41
Q

Non scarring alopecia
With 3 month of stressor

A

Tenogen effluvium

42
Q

Non scarring alopecia after chemo

A

Anagen effluvium

43
Q

Non scarring alopecia in accessible areas

A

Trichotillomania

44
Q

Crusting scutula organism

A

T schonleini

45
Q

Kerion orgnsm

A

T mentagrophyte
Hair perforation test positive

46
Q

Male pattern baldness

A

Hamilton pattern

47
Q

Female pattern baldness.

A

Ludwig pattrn

48
Q

Trichophyton

A

Involves skin hair(endothrix) and nails
Microconidia: pencil shape

49
Q

Exclamatory mark sign
Regular nail pitting
Going white overnight (white hair spared)
lymphocytes near hair bulb

A

Alopecia areata

50
Q

Alopecia totalis

A

Total loss of scalp hair

51
Q

Alopecia Universalis

A

loss of all body hair

52
Q

Ophiasis (alopecia)

A

Alopecia along Scalp margins.

53
Q

sisapho pattern of
hair loss

A

Hair loss spares the sides & back
of head.

54
Q

Androgenic alopecia
treatment

A

Minoxidil (topical) & finasteride

55
Q

Trichophyton, Microsporum, Epiderm mophyton microconidia
appearance

A

Pencil ,Spindle,club shape micro conidia

56
Q

LeSion with central Scarring

A

Lupus Vulgaris

57
Q

Lesion with Central clearing

58
Q

Lesion with central crusting

59
Q

MBL Characteristics

A

> 5 Skin lesion
1 Nerve involvement
SSS AFB positive
MDT duration 12M

60
Q

Leprosy dose

A

Rifampicin 600 mg OAMS
Dapsone 100 mg OD
clofazimine 300mg OAMS+ 50mg OD

61
Q

Type 1 Lepra reaction
* HSN RX
* seen in _
* Relation to Rx
* C/F
* Systemic Involvement
* Treatment

A

●Type 4 HSN
●BB /BT /BL
●within 12 M Pre-existing lesion #+ ●raised &tender
●No
●1st line- NSAIDS
DOC-Steroids

62
Q

Type 2 Lepra reaction
* HSN RX
* seen in _
* Relation to Rx
* C/F
* Systemic Involvement
* Treatment

A

●Type 3
●LL
●No Relation
●New nodular lesion
●fever, arthralgia, Orchitis
●DOC- Steroids
Most effective- Thallitomide
DO NOT STOP MDT.

63
Q

Thin, off white discharge
with fishy odour
No inflammation
Lab finding_ pH> 4.5, Clue cells positive whiff test

A

Bacterial vaginosis
(Gardnerella vaginalis)
Rx- Metronidazole,
Clindamycin

64
Q

Thin yellow-green malodorous ,frothy discharge
Strawberry vagina
Lab - pH >4.5 , motile trichomonasds +nt

A

Rx- Metronidazole or Clindamycin

65
Q

Thick cottage cheese discharge vaginal inflammation +nt
Lab- Normal pH , Pseudohyphae

A

Candida vaginitis
Rx fluconazole

66
Q

STD KIT 1

A

For cervical discharge ,urethral discharge, painful scrotal swelling

Tab Azithromycin 1 gm od stat + tab Cefixime 400 mg od stat
Treat all recent partners ( sympt partner in cervical discharge)

67
Q

STD kit-2

A

Green
Vaginal discharge
Tab secnidazone 2g OD Stat + cap fluconazole 150 mg OD Stat

68
Q

kit 3 I white

A

Genital ulcer non herpetic
inj Benzathine penicillin(2-4 Mv)- vial
Tab azithral 1 g
Treat all sexual Parther for
3 months

69
Q

kit_4 (Blue)

A

Doxycycline+ Azithromycin

70
Q

kit 5/ Red

A

Genital ulcer- Herpetic
Tab Acyclovir- 400m g
TDS for 7 days

71
Q

kit 6 / Yellow

A

Lower abd pain
Tab cefixime 400 mg OD stat + tab Metronidazole 400 mg BD x 14 days + Doxycycline 100 mg BD x 14 days

72
Q

kit 7 /Black

A

Inguinal Bubo
Tab Azithromycin + Tab Doxy

73
Q

Painful genital ulcers with vesicles and erosion

74
Q

Painful genital ulcer with raised lesion

A

Chancroid(H. Ducreyi)

75
Q

Painless hard and indurated genital ulcer with painful and rubbery LN

A

Chancre (syphillis)

76
Q

Painless beefy red genital ulcer

A

Granuloma inguinale

77
Q

Painless genital ulcer with inguinal bubo

A

LGV (chlamydia)

78
Q

Pemphigus

A

Flaccid bullae
Dsg 1 - subcorneal(granulosum layer)
P. Foliaceus, P. Erythematosus
Dsg 3 - suprabasal (spinosum layer)
P. Vulgaris, p vegetans(oral lesion +nt)

79
Q

Bullous pemphigoid

A

BP ag
Tense bullae with pruritis(eosinophils)
IF : IgG/c3 -DE jnc against BP ag

80
Q

CBD OF CHILDHOOD

A

Linear IgA deposition
String of pearls appearance
Rx Dapsone

81
Q

Dermatitis herpetiformis

A

Extensor pruritis
IF : picket fence granular deposition of IgA @ dermal papillae
Hp: Neutrophils + with papillary microabscess

82
Q

Wardenburg syndrome

A

Piebaldism + heterochromia iridis

83
Q

Contact leukoderma

84
Q

Chemical irritant in alta

A

Crocein
Scarlet MOO
Yellow 3 solvent

85
Q

Chemical irritant in Bindi

86
Q

Mc chemical in cement

87
Q

Chemical in hair dye

A

Parabutyl catechol

88
Q

BCC

A

Raised pearly nodule
True palisading

89
Q

Mycoises fungoides

A

Pautrier’s microabscess
Epidermotropism
Cerebriform nucleus

90
Q

ABCDE RULE OF MELANOMA

A

Asymmetry
Borders
Color
Diameter
Evolving

M imp prognostic factor: Breslow depth

91
Q

Actinic keratosis

A

Cutaneous horn
Premalignant to Sq c ca

92
Q

Seborrhoeic keratosis

A

Stuck on brownish appearance
Not premalignant.

93
Q

NF 1 chr?

94
Q

NF2 chromosome?

95
Q

All neurocutaneous sx are AD except?

A

SWS (SPORADIC)
At chr 9
Gene GNAQ

96
Q

Tuberous sclerosis chr?

A

9,16
1- Hamartin
2- Tuberin

97
Q

VHL chr and gene

A

Chr 3p at HIF GENE (VEGF Increase)

98
Q

ATM

A

AR
Chr 11 at ATM gene

Derma (1 decks)

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