Brugada syndrome

Question 1

What is brugada syndrome?

Answer 1

An inheritable condition which accounts for part of a group of patients with idiopathic ventricular fibrillation.

Question 2

Aetiology of brugada syndrome?

Answer 2

12 associated genes - cardiac sodium and calcium channels

Autosomal dominant inheritance pattern

8x more likely in males

Question 3

Risk factors for risk of arrhythmia?

Answer 3

Fever

Excessive alcohol intake

Large meals

Dehydration

Electrolyte abnormalities

Question 4

Clinical features of brugada syndrome?

Answer 4

Patients may be asymptomatic or present with palpitations and syncope due to arrhythmias.

Common cause of sudden cardiac death

Question 5

ECG appearance for brugada syndrome?

Answer 5

ST elevation in V1-V3

ECG findings may be intermittent and change over time

Question 6

Management of brugada syndrome?

Answer 6

Extend genetic testing to family

ICD (implantable cardioverter defibrillator)

Avoid triggers