Brugada syndrome Flashcards
1
Q
what is it?
A
autosomal dominant inheritance
2
Q
who is it more common in?
A
males
3
Q
pathology
A
mutation of cardiac sodium channel gene = SCN5A
no structural abnormalities
4
Q
when does it present?
A
40s most commonly
5
Q
predisposes to?
A
ventricular tachyarrhythmias
6
Q
clinical features
A
asymptomatic in many cases syncope cardiac arrest - nocturnal ECG changes paroxysmal agonal breathing family history
7
Q
ECG changes
A
ST elevation in right chest leads
coved morphology
RBBB/incomplete RBBB
AF can be associated cause
8
Q
what can bring it on -ECG changes?
A
large meal fever drugs post MI beta blockers cocaine alpha agonists sodium channel blockers DC cardioversion ]hypothermia
9
Q
diagnosis
A
positive ECG + 1 of diagnostic criteria
10
Q
ECG
A
may not show signs all the time
place leads V1 and V2 more cranially
11
Q
diagnostic criteria
A
proven VT/VF family history of sudden cardiac death <45 positive ECG criteria in family member electrical induction of VT syncope nocturnal agonal respiration
12
Q
physical examination
A
will be normal, done to rule out other conditions
13
Q
treatment
A
implantable cardioverter defibrillatory
medications
14
Q
medications used
A
quindine
tedisamil
isoproterol
proven to be less effective
