Bronchial Asthma

Question 1

Introduce Asthma

Answer 1

it is a physiologically defined as an increased responsiveness of the bronchial constriction to stimuli, that will change in severity spontaneously or in response to therapy.

Question 2

Asthma therapies are divided into

Answer 2

short term relievers

long term controllers

Question 3

Asthma is a disease mediated by (IgG) antibodies bound to mast cells in the airway mucosa T/F

Answer 3

False IgE instead IgG

Question 4

immediate bronchostriction mediators

Answer 4

histamine, tryptase, leukotrienes C4 and D4, and prostaglandins.

Question 5

immediate bronchostriction mediators

Answer 5

histamine, tryptase, leukotrienes C4 and D4, and prostaglandins.

Question 6

Effect of sympathomimetic drugs on asthma

Answer 6

bronchodilations of the airway muscles by preventing release of bronchoconstricting substances.
also prevents microvascular leakage and increase mucociliary transport

Question 7

Sympathomimetic agents of Asthma

Answer 7

mainly beta2 blockers; Albuterol, salmeterol, formoterol

epinephrine, isopretenol used in special situation because of cardiac effects.

Question 8

Methylxanthine drugs of Asthma

Answer 8

theophylline
methylxamine
threobromine

Question 9

methylxanthine has positive chronotropic and intropic effect on the heart

Answer 9

True

Question 10

Antimuscarinic agents on asthma

Answer 10

competitively inhibits effects of Ach at muscarinic receptors.
This blocks contraction of airway smooth muscle and increase secretion of mucus.

Question 11

Example of Antimuscarinic drugs

Answer 11

Atropine and it’s more selective ammonium derivative, ipratropium bromide.

Question 12

Corticosteroids act directly to prevent bronchoconstriction, reduce bronchial reactivity and reduce frequency of asthma exacerbations. T/F

Answer 12

False. They do not act directly to prevent bronchoconstriction.

Question 13

Aerosol treatment is one the best ways to decrease systemic adverse effects of??

Answer 13

Corticosteroids

Question 14

Cromolyn and Nedocromil are;
A.are extremely stable but extremely insoluble
salts
B. inhibits both antigen and exercise induced asthma
C. they have effect on airway smooth muscle tone
D. they are ineffective at reversing asthmatic bronchospasm
E. They are only of use prophylactically

Answer 14

T
T
F
T
T

Question 15

Leukotriene Pathways Inhibitors

Answer 15

include Thromboxanes and Prostaglandins

Question 16

Leukotriene

Answer 16

Leukotriene B4 is a potent neutrophil chemoattractant, and LTC4 and LTD4 exert many effects known to occur in asthma, including bronchoconstriction, increased bronchial reactivity, mucosal edema, and mucus hypersecretion