Breathlessness- Examinations Flashcards
Reasons to request an arterial blood gas
• Acid base balance disturbances= acidosis or alkalosis, Respiratory or Metabolic
• Respiratory disturbances= oxygenation and ventilation adequate. Hypoxemia, hypercapnia, respiratory failure
Values checked in an arterial blood gas
• PH
• PaO2
• PaCO2
• Bicarbonate (HCO3)
• Base excess
• Carboxyhemoglobin
• Methemoglobin
• Hemoglobin, lactate, sodium, potassium
Blood- pH values
• Normal 7.35-7.45
• <7.35= Acidaemia
• >7.45= Alkalemia
Arterial blood gas- bicarbonate values
• Normal range 22 – 26
• Can be altered as part of a primary metabolic derangement
• The kidneys can excrete or retain bicarbonate to counter a respiratory disturbance (compensatory mechanism)
• Use either Base excess or bicarbonate to look at metabolic status
• >26 mmol/l -> alkalosis
• <22mmol/l -> acidosis
Base excess values
• Range is -2 to +2
• Derived value -> not actually measured but calculated by the machine
• How much acid (H+) must be added or removed from blood to bring it’s PH back to normal
• BE < -2 = acidosis
• BE > +2 = alkalosis
Acid base balance
• The most important buffer system in the body is the carbonic acid-bicarbonate system
• H2O+CO2 = H2CO3 = HCO3-+H+
• Main enforcers are the kidneys and lungs= Adjusting ventilation affects CO2 concentrations, Rate of excretion of HCO3 and H+ controlled by the kidney
Metabolic acidosis- anion gap
• In blood the number of cations (+) is equal to anions (-)
• Adding all the measured cations and anions together gives a gap which reflects anions which are not measured (plasma proteins and organic acids)
• (sodium+potassium) - (chloride+bicarbonate) = Anion Gap
• Normal anion gap is 10-12
• If high represent additional anion (acid) in the blood
Arterial blood gas- PaCO2
• 4.5-6.0 Kpa
• Measures how good ventilation is
• >6.0 Kpa hypercapnia -> hypoventilation -> respiratory acidocis
• <4.5 Kpa hypocapnia -> hyperventilation -> respiratory alkalosis
• Type 2 respiratory Failure PaCo2 of > 6 Kpa
Causes of type 2 respiratory failure- PUMP failure
• Lungs -> COPD, severe asthma
• Outside the lungs -> fluid (effusion, ascites) , air ( pneumothorax) , fat(Obesity hypoventilation syndrome) , bones( scoliosis)
Causes of type 2 respiratory failure- nerve muscle complex (messenger carrier)
• Central- stroke, tumour, opoids, heroin
• Peripheral nerves- motor neuron diseases, bilateral diaphragm palsy
• Neuromuscular junction- myopathy, diaphragm palsy
Arterial blood gas- PaO2 (partial pressure of oxygen)
• In room air= >12 kpa (10 kpa for the elderly)
• <12 Kpa is hypoxemia
• <8kpa type 1 respiratory failure
• FiO2- fraction of oxygen in the inspired air, 21% or 0.21 of room air
Different devices used for air flow
• Nasal canulae, 2-4 L/min, 0.28-0.35
• Hudson mask, 6-10 L/min, 0.35-0.5
• Non re-breathe mask, 5-15 L/min, 0.6-0.9
• Venturi mask, 2-15 L/min, 0.24, 0.28, 0.31, 0.35, 0.40, 0.6
• Humidified oxygen, 2-15 L/min, 0.24-0.6
• High flow nasal oxygen, over 40L/min, 0.35-1ish with mouth closed
Causes of hypoxaemia
• Ventilation perfusion mismatching (e.g Pulmonary embolism)
• Right to left Shunt (cardiac or pulmonary)
• Decreased Oxygen Diffusion (e g Pulmonary fibrosis)
• Hypoventilation (Heroin overdose)
• Low oxygen content of air (at heights)
Blood gas-oxygen
• Rule of thumb to check for hypoxemia is “the Pao2 should be 10-15 kpa less then the FiO2”
• Example= on room air(Fio2 21%) you would expect the Pao2 to be -> 21-10= 11 Kpa (normally 10-14 kpa)
• If someone is on oxygen with a 40 % Venturi mask(FIo2 is 40%) , there PaO2 should be -> 40-15= 25 Kpa( 25-30 Kpa)
Alveolar arterial gradient (A-a)
• Difference between alveolar concentrations of oxygen and arterial concentrations of oxygen. Measure of the alveolar gas exchange
• Normal A-a gradient= Alveolar hypoventilation (Opoid), Low oxygen content (at heights)
• Raised A-a gradient= Diffusion defect (Pulmonary fibrosis), V/Q mismatch (Pulmonary embolism), Right to left shunt (intrapulmonary or cardiac)
Oxygen- Haemoglobin dissociation curve
• A non linear relationship, after a certain saturation it drops steeply
• Oxygen is mainly carried combined to Hb
• Left shift= Higher Hb-O2 affinity (lower, CO2, higher pH, lower temperature)
• Right shift= Reduced Hb-O2 affinity (Higher COS, lower pH, higher temperature)
Hypoxaemia and Hypoxia
• Hypoxemia -> Low Oxygen in the blood , PaO2 <12 Kpa
• Hypoxia -> reduced oxygen delivery to the cells causing them to switch to anaerobic respiration
What can Hypoxia be due to
• Poor oxygenation of the blood aka hypoxemia
• Poor oxygen carrying capacity ( anemia )
• Poor delivery of oxygen/blood to the cells( Shock)
• Cells not being able to use the oxygen for aerobic respiration (e.g Cyanide poisoning)
Steps to interpreting an arterial blood gas
• 1st Step check the PH and determine whether it is academic or alkalemic
• 2nd step Check the PCO2 and decide whether it is a primary metabolic or respiratory disorder
• 3rd Step check at the Bicarbonate or base excess to confirm your conclusion about nature of disorder
• 4th Check the oxygen to rule out hypoxemia
Advanced steps for an arterial blood gas
• If metabolic acidosis -> Check the Anion gap to determine whether anion gap or normal anion gap acidosis
• For all disorders check compensatory response is adequate (change in PCO2 for metabolic, change In bicarbonate for respiratory)
• If Metabolic acidosis check the Pco2 is adequately reduced to rule out a superadded respiratory acidosis
• A-a gradient for hypoxemic patients
Arterial blood gas- ROME mneomonic
• Respiratory opposite= if the pH is up and Pco2 is down then its respiratory alkalosis. If the pH is down and the Pco2 is up then its respiratory acidosis.
• Metabolic equal= If the pH and HCO3 are up then its metabolic alkalosis. If the pH and HCO3 are down then its Metabolic acidosis
Arterial blood gas- rule of thumb
• Metabolic problems PH and PCO2 move in the same direction i.e. both go up
• In Respiratory Problems they tend to move in opposite directions
• Problem is mixed defect – both respiratory and metabolic acidosis etc
Metabolic acidosis
pH, PCO2, Bicarbonate and base excess all go down
Causes of metabolic acidosis- Diabetic ketoacidosis, Salicylate OD, Shock, Sepsis, Severe diarrhoea, Renal failure
Metabolic alkalosis
pH, Pco2, Bicarbonate, base excess all went up. Change to PCO2 is minimal
Causes of metabolic alkalosis
• Drugs – diuretics , steroids
• GI loss – vomiting ,Bulemia , diarrhoea etc
• Renal loss – aldosterone excess , liquorice
• Hypokalemia