Breathing Control Lecture 14 Flashcards

1
Q

anatomical location of the controller portion of breathing

A

medulla and pons

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2
Q

name of neurons responsible for signalling

A

dorsal respiratory neurons

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3
Q

hyperpnea

A

accelerated breathing to keep up with increased CO 2 production

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4
Q

tachypnea

A

breathing at a rate above normal, with total ventilation usually up, but sometimes alveolar ventilation can actually be down due to dead space/tidal volume considerations

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5
Q

dyspnea

A

feeling of or consciousness of shortness of breath

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6
Q

eupnea

A

normal breathing

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7
Q

Apnea

A

no breathing

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8
Q

nerves involved in breathing and their functions (3)

A

vagus - sensory from peripheral chemoreceptors
and mechanical receptors
glossopharyngeal - sensory for peripheral chemoreceptors
dorsal respiratory group - via phrenic signals diaphragm

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9
Q

ventral respiratory group is responsible for… (neurons)

A

active expiration

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10
Q

pons groups and their responsibilities

A

pneumotaxic center - regulates inspiratory volume and rate
apneustic center - prolongs inspiratory effort with an increase in the depth of inspiration; usually inhibited by the pneumotaxic center and the vagus

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11
Q

central chemoreceptors alter the ventral respiratory group when blood CO2 changes the…

A

pH of the CSF; because H does not cross the BBB but CO2 does; 3/4 of detection

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12
Q

peripheral chemoreceptors are…

A

1/4 of the detection and in the carotid bodies and can detect hypoxemia

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13
Q

long term adaptation to elevated PaCO2 is achieved via…

A

kidney retention of bicarb.

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14
Q

threshold for activation of hypoxic ventilatory response

A

60 mmHg PO2

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15
Q

if you have low pH, high pCO2 and low PO2 then ventilation is…

A

increased!

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16
Q

symptoms of acute mountain sickness

A

Acute pulmonary edema possibly due to HPV

Acute cerebral edema due to vasodilation of capillaries in brain

17
Q

Acute response to rapid elevation gain

A

hyperventilation that lowers PaCO2

18
Q

Long term response to elevation gain

A

kidneys begin to secrete HCO3 and to retain H to compensate for alkalosis

19
Q

Longer term acclimitization

A

Capillary profusion (angiogenesis), increased mitochondria, increased hematocrit, increased diffusion capacity

20
Q

what is the name of the response that prevents over-inflation of the lungs?

A

Herring-Bruer response mechano-stretch sensors in the smooth muscles of the bronchioles and bronchii when Vt = 1.5 Liters

21
Q

irritant receptors are located in the…

A

bronhii and trachea

22
Q

J receptors

A

sense fluid buildup in the lungs, cause shallow rapid breathing and dyspnea

23
Q

chest walls receptors

A

may also give the sensation of dyspnea

24
Q

the technical definition for the anaerobic threshold is….

A

the limit of the body’s ability to compensate for the increased acid production due to lactic acidosis and the switch from oxidative metabolism to glycolysis

25
Q

respiratory depression from brain edema can be allayed by injecting…

A

hypertonic solution

26
Q

obstructive sleep apnea definition

A

more than 15 apneas or hypopneas of greater than 10 second duration in one hour of sleep

27
Q

sleep apnea is diagnosed by…

A

polysomnography

28
Q

sleep apnea causes metabolic alkalosis because…

A

the body retains CO2 from the hyperventilation cycle, which therefore causes respiratory acidosis. The body’s long term adaptation response (to produce HCO3) causes metabolic alkalosis when the patients are breathing normally (i.e. during the day)

29
Q

cor pulmonale

A

right ventricular failure

30
Q

the steps to CP are by sleep apnea patients…

A

HPV -> pulmonary hypertension -> incr. right ventricular afterload -> CP
chronic nighttime hypoxia increases erythropoiesis and induces polycythemia which makes the blood more viscous and therefore increases afterload