breastfeeding Flashcards
mammogenesis begins
soon after conception
breast capable of milk production at
16-20 wks
estrogens effects on mammogenesis
increases sensitivity to prolactin & PL
stimulates mammary growth & development
promotes prolactin secretion by ant pituitary
progesterone effects on mammogenesis
enhances lobuloalveolar development
inhibits milk secretion during pg
placental lactogen
glandular tissue of alveoli
prolactin
acts with other hormones to stimulate development of alveoli and ductal system
pg levels consistent with milk production but progesterone works as deterrent
oxytocin
no effect on mammary development
sensitivity of myoepithelial cells up in pg
enzyme from placenta keeps levels low
lactogenesis
initiation of milk production takes 4 days to complete but usually pronounced sensation around 2-3days
lactogenesis is suppressed by
progesterone
milk production & release is controlled by
suckling
what is prolactin’s role in lactogenesis
Suckling → Prolactin release from ant pit AND stimulates nipple/areola sending impulses to hypothalamus
Hypothalamus → ↓ prolactin inhibiting factor
↑ Prolactin at end of feed → ↑ milk volume, fat and protein in next feeding
three patterns of secretion
week one: base levels high (just from fall of E&P), slight increase with suckling
week two to 3 months: base levels 2-3x higher and suckling levels 10-20x higher
after 3 months: base levels similar to non-lactating & do not rise much with suckling
when is the window to implement interventions that will be successful?
week 2 to 3 months
FIL
feedback inhibitor of lactation protein
increased when milk left in breast
galactopoeisis is dependent upon
periodic suckling
removal of milk
intact hypothalamus/pituitary/Oxytocin – lots of things can mess this up (ex: Sheehans is worst, shift work, excessive exercise, anxiety/stress/excessive weight loss)
oxytocin release is stimulated by
thinking of the infant
hearing a baby cry
orgasm
oxytocin release reduced by
anxiety stress pain fatigue alcohol consumption
synthesis of milk is most active during
suckling
colostrum
appears first in 2nd trimester – thick, oily, dried in crusts
last 2-3 days PP
highest in protein 3xmore than mature milk (aa’s, IgA, lactoferrin)
lower in CHOs, fat and calories
transitional milk
mix of colostrum and mature milk
mature milk
replaces transitional over 1-2 weeks
Overall content consistent
Only vitamin & fat content relevant to maternal nutrition
200 known constituents- why we can’t replicate it in formula easily.
Fat 3%
Protein 0.8-1.2%
CHO 6.8-7.2%
Water 87%
Vitamins/Mineral 0.2%
60-75 kcal/dl = 20kcal/oz
500 ml/d at 1 wk to 750-850ml/day at 6 mos
what are some enzymes provided for the baby in the milk?
anti-infective: lysozyme, peroxidase, xanthine oxiase
digestive: amylase, lipase
immunoglobulins
sIgA - 100mg/ml Highest Ig in human milk
IgG - High for 2 weeks
IgM - High for 2 weeks
IgE - absent in human milk (good, so babies don’t have anaphylactic rxns)
carbohydrate composition
lactose- 6.8 g/dl
glucose - 14mg/100ml
galactose - 12mg/100ml
fucose - important in establishing bifidus, good prebiotic
factors which affect lipid content
Prenatal weight gain
Length of gestation – full term with more fat
Parity – the more pregnancies, the fattier the milk is
Volume of milk: more volume in sugary foremilk, less in fatty hind milk
Timing of feed – fore/hind milk