Breast Robbins

Question 1

Most important factor in absence of distant metastases

Answer 1

Axillary lymph node metastasis

Question 2

Only benign lesion in male breast

Answer 2

Gynecomastia

Question 3

Paget disease of the nipple stains positive with

Answer 3

PAS

Question 4

Incidence of ______ did not decrease after introduction of mammography screening

Answer 4

LCIS

Question 5

Malignant (but less than 0.05% metastasize) lesion of interlobular stroma

Answer 5

Angiosarcoma

Question 6

Irregular palpable mass that mimics invasive carcinoma clinically and on imaging

Answer 6

Duct ectasia

Question 7

Phyllodes tumor tumor spread characteristics

Answer 7

Usually low grade that may recur but do not metastasize
Regardless of grade, lymphatic spread is rare
Lymph node dissection is contraindicated

Question 8

Nipple discharge most worrisome for carcinoma if (3 things)

Answer 8

Spontaneous
Unilateral
Age > 60

Question 9

ER(-), HER2(-) “basal-like” triple negative carcinoma most common in

Answer 9

Young, premenopausal females, especially African American or Hispanic

Question 10

Coopers ligaments tethered to edematous skin

What is this seen in?

Answer 10

Peau d’orange

Inflammatory carcinoma

Question 11

Mutations responsible for 80-90% of “single gene” occurrences

Answer 11

BRCA1 and BRCA2

Question 12

Most and least favorable prognoses in breast cancer (molecular subtype)

Answer 12

Most favorable - well differentiated, ER(+), HER2(-), low proliferation
Least favorable - poorly differentiated, ER(-) and/or HER2(+)

Question 13

Predictors of risk but unlikely to be true precursors of carcinoma

Answer 13

Proliferative breast disease WITHOUT atypia

Question 14

Flat epithelial atypia seen in

Answer 14

Adenosis (non-proliferative breast change)

Question 15

Proliferative breast disease without atypia composed of intraductal lesions with fibrovascular cores lined by both myoepithelial and luminal cells

Answer 15

Papilloma