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PATH | BREAST > BREAST | GOLJAN > Flashcards

BREAST | GOLJAN Flashcards

1
Q

define : apocrine metaplasia

seen in ?

A

presence of large, pink cells

seen in FCC - epithelial hyperplasia

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2
Q

greenish brown nipple discharge

A

plasma cell mastitis AKA mammillary duct ectasia

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3
Q

define: galactorrhea

causes

A

milky discharge from nipple

  1. prolactinoma - MC
  2. hypothyroidism - TRH stimulates prolactin
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4
Q

bloody nipple discharge

A

intraductal papilloma

ductal cancer

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5
Q

locations of breast pathology

A
  1. areola/nipple
  2. lactiferous sinus
  3. major duct
  4. terminal duct
  5. lobule
  6. stroma
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6
Q

which pathology is seen in STROMA?

A

fibroadenoma

phyllodes tumor

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7
Q

which pathology is seen in AREOLA/NIPPLE?

A

breast abscess

paget’s disease of the nipple

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8
Q

which pathology is seen in LACTIFEROUS SINUS?

A

breast abscess
intraductal papilloma
plasma cell mastitis

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9
Q

which pathology is seen in MAJOR DUCT?

A

ductal cancer

FCC*

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10
Q

which pathology is seen in TERMINAL DUCT?

A

tubular carcinoma

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11
Q

which pathology is seen in LOBULE?

A 
lobular carcinoma
sclerosing adenosis (FCC)
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12
Q

*mondor disease

A

superficial thrombophlebitis of veins overlying the breast

seen as a palpable, painful cord

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13
Q

MCC of breast pain <50

A

FCC

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14
Q

types of FCC

A
  1. fibrous
  2. cystic
  3. sclerosing adenosis
  4. ductal hyperplasia
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15
Q

describe - cystic FCC

A

cysts hemorrhage

*blue-domed cysts

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16
Q

which type of FCC is mistaken for cancer?

A

sclerosing adenosis

- b/c of microcalcifications

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17
Q

describe : traumatic fat necrosis

A

trauma to breast leads to fibrosis and dystrophic calcification

acute- painful mass
chronic- painless indurated mass

lipid laden macrophages with giant foreign body cells

18
Q

MC breast tumor in women <35

A

fibroadenoma

19
Q

describe : fibroadenoma

A

discrete painful or painless movable tumor
multiple lesions / bilateral - LUMPY BUMPY
located in stroma
estrogen sensitive - size changes accordingly

seen in post renal transplant women

20
Q

describe : phyllodes tumor

A

large bulky tumor \ lobules with cysts
LEAF LIKE projections
located in stroma

21
Q

location of : intraductal papilloma

A

lactiferous duct

22
Q

MCC of acute mastitis

A

staph aureus
red, swollen, painful breast

breast feeding!

23
Q

*clinical findings in breast cancer

A

painless mass
painless axillary LAD
skin \ nipple retraction \ discharge

24
Q

non invasive breast cancer types

A

DCIS

LCIS

25
Q

describe DCIS

A

ductal carcinoma in situ
non palpable
seen on mammogram b/c of microcalcifications

26
Q

which non invasive cancer shows CASEOUS NECROSIS

A

comedocarcinoma - DCIS

27
Q

which non invasive cancer has lacks E-CADHERIN

A

LCIS

28
Q

describe LCIS

A

lobular carcinoma in situ
non palpable
NO calcifications and therefore cant be identified
*cancer in opposite breast

29
Q

name the INVASIVE types of breast cancer

A 
invasive ductal carcinoma
invasive lobular carcinoma
Paget disease of the nipple
medullary carcinoma
inflammatory carcinoma
30
Q

stellate morphology

A

invasive ductal carcinoma

31
Q

describe : invasive ductal carcinoma

A 
stellate morphology
firm, fibrous, ROCK HARD mass
gray-white color 
MC type of all breast cancers
gritty on cut surface
32
Q

describe : invasive lobular carcinoma

A

usually bilateral

“L in lobular”
neoplastic cells are either arranged Linearly ( indian file)
or in Lobules ( bulls eye )

33
Q

describe : PAGET disease of the nipple

A

eczematous patches on nipple
with or w/o nipple retraction
extension of DCIS

34
Q

*paget cells

A

large cells in epidermis with clear halo

35
Q

describe : medullary carcinoma

A

bulky, soft, fleshy tumor
w LYMPHOCTYIC infiltrate
BRCA1
good prognosis

the “medulla” is usually bulky, soft, and filled w/ cells

36
Q

describe : inflammatory carcinoma*

A 
invasion of lymphatics by carcinoma
causes lymphedema
this prevents sweat glands from closing 
leading to ERYTHEMATOUS breast with 
PEAU D'ORANGE
poor prognosis b/c of invasion
37
Q

peau d’ orange

A

inflammatory carcinoma

38
Q

lacks e-cadherin

A

LCIS

39
Q

bulls eye appearance

A

invasive lobular carcinoma

40
Q

lymphocytic infiltrate

A

medullary carcinoma

PATH | BREAST (1 decks)

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