Breast, Final W2015 Flashcards
What term refers to a condition where breast tissue, nipple and areola are absent?
Amastia
What term refers to a condition where the mammary gland tissue is absent but the nipple and areola remain present?
Amazia
What term refers to the presence of breast glandular tissue but no nipple or areola?
Athelia
What is a supernumerary nipple and where does it arise?
It’s an additional nipple that may occur along the milk line.
What is polymastia?
Supernumerary breast tissue or ectopic breast tissue, usually on the milk line.
What usually causes an inverted nipple?
Fibrous bands of tissue that tether the nipple in an inverted position. 90% are bilateral.
When is galactorrhea most disconcerting?
D/c is unilateral, bloody or associated with breast mass. It may indicate malignancy.
Inflammation of the parenchyma of the mammary gland during lactation is often termed what?
Puerperal mastitis
What is a common myth about mastitis?
The it is an acute infection. It is rarely associated with an infection (although this is possible if the nipple is cracked in which cased it is usually caused by staph aureus or strep epidermidis)
What condition is characterized by keratinizing squamous epithelium in the duct system of the nipple causing pain in the sub-areolar area?
Peri-ductal mastitis (90% of pts are smokers)
What condition is characterized by dilatations of the sub-areolar ducts and usually occurs in 5th or 6th decade of life to multiparous women?
Mammary duct ectasia
What is the single most common disorder of the breast and accounts for more than half of all surgical operations that are performed on the female breast?
Fibrocystic breast disease
How is fibrocystic breast disease diagnosed?
It’s too dense for mammography.
Usually, clinical diagnosis from history and sxs
Definitive diagnosis is by biopsy or aspiration
What are the microscopic findings of fibrocystic breast disease?
Fibrosis
Sclerosing ductal epithelium proliferation
Adenosis
Apocrine metaplasia
Multi-layering of the ductal cells or ingrowth of the cells towards the center of the duct
What does fat necrosis of breast tissue look like microscopically?
Irregular fatty spaces that are surrounded by foamy histiocytes and multinucleated giant cells
What condition is characterized by a single hard mass or multiple hard masses that are made up of collagenized stroma surrounding atrophic ducts and lobules?
Lymphocytic mastopathy
What are the microscopic findings in lymphocytic mastopathy?
A thickening and fibrosis of stromal tissue and lymphocytic infiltrates that surrounds the epithelium and blood vessels
Who typically gets lymphocytic mastopathy?
Women with type 1 diabetes mellitus or autoimmune thyroiditis
What is the difference between Adenosis and Adenoma?
Adenosis is an increased number of glandular components
Adenoma is a benign lesion with more glandular tissue involved and is more organized
What is the most common benign tumor of the breast?
Fibroadenoma
What tumor is characteristically a well circumscribed mass with a prominent fibrotic capsule?
Fibroadenoma
How do fibroadenomas respond to hormones?
They are responsive to hormones:
Increase in size during pregnancy and late luteal phase of menses
Regress after menopause
What is a lactating adenoma
A fibroadenoma. A localized focus of hyperplastic cells seen in breast tissue during pregnancy.
Marked cytoplasmic vacuolization seen in the hyperplastic lobules.
What are the two types of intraductal papillomas and how are they different?
Solitary - originates in the large ducts and is located centrally beneath the nipple
Multiple - located in the terminal ducts at the periphery of the breast
