Breast cancer Flashcards
1
Q
What are the cohesion abnormalities of cancer cells?
A
1) Decrease intercellular cement
2) Decrease desmosomes
3) Loss of contact inhibition
4) Increase of negativity of electric charges
2
Q
What increases the negativity of electric charges of cancer cells?
A
1) Glutamic acid
2) Sialic acid
3) Phospholipids
4) Aspartic acid
3
Q
Which gene is mutated in a male with breast cancer?
A
BRCA-2
4
Q
How many doublings before we can diagnose cancer?
A
30 doublings (1cm^3 or 1g) = 10^9 cells
5
Q
How many doublings before we can say this cancer is not compatible with life?
A
40 doublings (1kg) = 10^12 cells
