Breast Cancer

Question 1

What is the standard endocrine therapy in men?

Answer 1

Tamoxifen, b/c efficacy of aromatase inhibitors may be lower in men due to incomplete estradiol suppression from feedback loops.

Question 2

What is “Basal-like” breast cancer associated with?

Answer 2

• Triple negative
• While most triple negative breast cancers are basal-like, not all triple negative breast cancers are basal-like.

Question 3

Per the population based case control study (Darby et al), what % increase in the rate of major coronary events for each 1 Gy increase in mean heart dose?

Answer 3

7.4% increase for 1 Gy increase

Question 4

What was the false negative rate of sentinel node biopsy among pts receiving neoadjuvant chemo with node positive breast cancer in ACOSOG Z1071?

Answer 4

12.6% (study included T0-4, N1-2 disease)

Question 5

Which of the breast cancer histology is the most favorable?

• Apocrine
• Pleomorphic lobular
• Medullary
• Metaplastic

Answer 5

Medullary carcinomas are typically hormone receptor positive, are rarely associated with nodal positivity, and have high rates of local control.

Apocrine carcinomas are typically hormone receptor negative and are intermediate prognosis.

Pleomorphic lobular carcinomas and metaplastic carcinomas are typically high grade and associated with poor prognosis.

Question 6

Male breast cancer is most commonly associated with which gene?

Answer 6

BRCA2